Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application

Abstract

Three composite sponges were made with 10% of curcumin and by using polymers, namely, chitosan and gelatin with various ratios. The chemical structure and morphology were evaluated by FTIR and SEM. These sponges were evaluated for water absorption capacity, antibacterial activity, in vitro drug release, and in vivo wound healing studies by excision wound model using rabbits. The in vivo study presented a greater wound closure in wounds treated with curcumin-composite sponge than those with composite sponge without curcumin and untreated group. These obtained results showed that combination of curcumin, chitosan and gelatin could improve the wound healing activity in comparison to chitosan, and gelatin without curcumin.

Chitosan Based Scaffolds and Their Applications in Wound Healing

“…The higher content of gelatin in composite sponge exhibited a faster release behaviour up to 240 min. These composite sponges were also found to enhance the formation of collagen and wound closure in vivo and therefore improved the wound healing activity ( Van et al, 2013).…”

Chitosan Nanoparticles for Generating Novel Systems for Better Applications: A Review

“…Chitosan powder has also been used for treating wounds and it was observed that it took only three weeks to heal the wounds applied with chitosan whereas in control groups without chitosan it took four weeks to heal the wounds [63]. Some workers have used a combination of chitosan, gelatin and curcumin for studying wound closure [66]. Workers have used a matrix composed of cotton fabric with chitosan that is embedded with silver nano particles and other researchers have attempted to combine chitosan and silver nanoparticles for improving wound healing properties chitosan [67].…”

Fabrication and characterization of PCL/gelatin/curcumin nanofibers and their antibacterial properties

“…Gelatin's biocompatible and biodegradable properties are similar to collagen, but pure collagen is much more expensive than gelatin. This natural polymer also prevents fluid loss, which is an important factor in wound-healing applications [16]. Therefore, because of its many merits, gelatin is used extensively in biomedical applications.…”

“…The cell viability assay indicated that these nanofibers can be applied in skin cancer treatments [23]. CUR has also been electrospun with cellulose acetate, PLA, chitosan-Gel, and PCL [16,19,24,25].…”