Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

Killian, Peter H.; Kronski, Emanuel; Michalik, Katharina; Barbieri, Ottavia; Astigiano, Simonetta; Sommerhoff, Christian P.; Pfeffer, Ulrich; Nerlich, Andreas G.; Bachmeier, Beatrice E.

doi:10.1093/carcin/bgs312

Cited by 156 publications

(129 citation statements)

References 51 publications

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“…Curcumin has the ability to inhibit cell growth and induce apoptosis in both androgen-dependent and androgenindependent prostate cancer cell lines acting through the regulation of apoptosis relative signaling (Hilchie et al, 2010;Wei et al, 2013) and other crucial proteins (Teiten et al, 2012;Horie, 2012;Kang et al, 2013). By targeting the inflammatory cytokines CXCL-1 and -2, curcumin also inhibited prostate cancer metastasis in vivo (Killian et al, 2012). ).…”

Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

Tao²,

Zhao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Inhibitor of DNA binding 1 (Id1) plays an important role in genesis and metastatic progression of prostate cancer. We previously reported that down regulation of Id1 by small interfering RNA could inhibit the proliferation of PC3 cells and growth of its xenografted tumors. Curcumin, the active ingredient of turmeric, has shown anti-cancer properties via modulation of a number of different molecular regulators. Here we investigated whether Id1 might be involved in the anti-cancer effects of curcumin in vivo and in vitro. We firstly confirmed that curcumin inhibited cell viability in a dose-dependent fashion, and induced apoptosis in PC3 cells, associated with significant decrease in the mRNA and protein expression of Id1. Similar effects of curcumin were observed in tumors of the PC3 xenografted mouse model with introperitoneal injection of curcumin once a day for one month. Tumor growth in mice was obviously suppressed by curcumin during the period of 24 to 30 days. Both mRNA and protein levels of Id1 were significantly down-regulated in xenografted tumors. Our findings point to a novel molecular pathway for curcumin anti-cancer effects. Curcumin may be used as an Id1 inhibitor to modulate Id1 expression.

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Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

Tao²,

Zhao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Killian et al showed that CXCL1 and -2 share an almost identical proximal promoter region that contains a perfect NF-ĸB binging site (26). This result shows activation of NF-ĸB increases the expression of CXCL1 and -2.…”

Section: Curcumin Down-regulates Inflammatory Cytokines' Expressionmentioning

confidence: 98%

“…Bachmeier et al (25) and Killian et al (26) reported that curcumin prevents NF-ĸB activation by inhibiting phosphorylation and degradation of IĸBα. Curcumin is also shown to inhibit the activation of p65 (one of the NF-ĸB transcription factor family) in estrogen receptor (ER)-negative breast cancer cells (25) and in prostate cancer cells (26). Singh et al showed that curcumin inhibits NF-ĸB activation pathway in the signal transduction cascade of NF-ĸB activation before the IĸBα phosphorylation but after the point at which signals transduced by various stimuli converge (27).…”

Section: Potential Anti-migration Anti-invasion and Anti-colony Formmentioning

confidence: 99%

Molecular Mechanisms of Anti-metastatic Activity of Curcumin

Deng

Verron

Rohanizadeh

2016

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Abstract. Cancer is the leading cause of death worldwide. Although cancer occurs as a localized disease, its morbidity and mortality rates remain high due to the ability of cancer cells to break-off from the primary tumor and spread to distant organs. Currently, chemotherapy is the main treatment for cancer; however, the increase in proportion of drug-resistant cancer cells and unpleasant side-effects of chemotherapy are still the major challenges in cancer therapy. Curcumin is a natural polyphenol compound and the main bioactive constituent of Indian spice turmeric, widely used in Indian and Chinese medicines. Curcumin has well-known therapeutic actions, including antiinflammatory, anti-microbial, anti-oxidant and anti-cancer properties. Curcumin induces cancer cell apoptosis through regulating various signaling pathways and arresting tumor cell cycle. Curcumin's therapeutic/ preventative actions on metastatic cancers have not been yet fully understood and studied. The present review explores the potential anti-metastatic mechanisms of curcumin, including inhibition of transcription factors and their signaling pathways (e.g., inflammatory cytokines (e.g., CXCL1, CXCL2, multiple proteases (e.g., uPA, MMPs), multiple protein kinases (e.g., MAPKs, FAK), regulation of miRNAs (e.g., miR21, miR181b) and heat shock proteins (HLJ1). In addition, possible synergistic actions of combination therapy of curcumin with current chemotherapies are discussed in this review.Despite all recent advances in oncology, cancer is still one of the deadliest diseases around the world (1). Cancer occurs as a localized disease but can spread to distant organs through migration, invasion and metastasis (2). Metastatic cancer is one of the major causes of death in cancer patients. Metastasis is a complex process involving multiple steps: (i) local migration through degrading basement membrane and extracellular matrix (ECM), (ii) intravasation into blood and/or lymphatic vessels, (iii) circulating to the target organ site, (iv) extravasation into target organ tissue and, finally, (v) multiplication in the target organ (2, 3). These steps are mediated by various factors, including growth factors, proteolysis degradation of extracellular matrix, cell-cell adhesion, cytoskeleton remodeling and changes of genes' expressions (2, 3). Metastasis is a non-random process that means each metastatic cancer type has its own preferred site of metastasis. For example, breast cancer cells preferentially metastasize to regional lymph nodes, liver, lungs and bone (4). Nowadays, there are different therapeutic approaches available for patients with metastatic cancers, including surgery, radiotherapy and chemotherapy. Chemotherapy remains the main treatment modality for cancer patients because of its ability of preventing invasion and metastasis. However, the morbidity and mortality rates in patients with metastatic cancer still remain high since current chemotherapy agents fail to selectively and effectively kill cancer cells without destroying normal ce...

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“…In addition, curcumin inhibits activation of NF-κB by down-regulating the upstream kinases caused by phosphorylation of IκB, NIK, and IKK [64]. Numerous studies have reported that curcumin can inhibit NF-κB pathway in various cancer cells, including breast, ovary, prostate, colorectum, and pancreas [65][66][67][68][69]. Curcumin also inhibits the expressions of COX-2 and cyclin D1 [70,71].…”

Section: Cip1mentioning

confidence: 99%

Dietary Phytochemicals as Cancer Preventive Agents: Efficacy and Mechanisms

Sakai¹

2015

J Bioanal Biomed

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Despite significant advances in cancer therapeutic modalities, available anti-tumor drugs display limited efficacy and sometimes carry a risk of severe adverse side effect. Therefore, it is important to identify and develop cancer chemopreventive agents without toxicity. Epidemiological examinations in human populations and experimental rodent studies provide evidence that certain types of phytochemicals suppress development and growth of cancers at various organ sites. A number of clinical investigations have been also conducted and shown that dietary phytochemicals are able to inhibit tumorigenesis, indicating several phytochemicals are regarded as cancer chemopreventive agents. Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is considered as the most biologically active constituent in drinking tea with respect to inhibiting cell proliferation and inducing apoptosis in cancer cells. EGCG appears to directly target receptor tyrosine kinases with inhibiting activation of the receptors and down-stream signaling pathways. In addition, EGCG has improving effects against obesity and insulin resistance, which leads to suppressing the development of obesity-related malignancies. Other polyphenolic phytochemicals, including curcumin and resveratrol, are also reported to exert anti-cancer effect. In this review article, we summarize the potential of dietary phytochemicals as anti-cancer drugs and those possible mechanisms against cancer, especially chemopreventive effect of green tea catechins.

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Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

Cited by 156 publications

References 51 publications

Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

Molecular Mechanisms of Anti-metastatic Activity of Curcumin

Dietary Phytochemicals as Cancer Preventive Agents: Efficacy and Mechanisms

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