Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway

Guo, Lei; Xue-jie, Chen; Hu, Yuhong; Yu, Zhijun; Wang, Hui; Liu, Jingze

doi:10.1002/ptr.4731

Cited by 109 publications

(63 citation statements)

References 42 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The p53 and FOXO3a formed part of regulation transcriptional network to control cancer cell growth and apoptosis (33,34). In addition, curcumin induced expression of p53 or/and FOXO3a in inhibition of cancer cell growth and other functions have been shown in other cell systems (27,28,35,36). However, whether curcumin affects the interaction of these proteins to facilitate the inhibitory effect of NPC growth remain to be determined.…”

Section: Discussionmentioning

confidence: 85%

Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin

Tang

Zhao

et al. 2014

International Journal of Oncology

View full text Add to dashboard Cite

Curcumin, one of the main bioactive components extracted from a traditional Chinese medicinal herb, exhibits potent anticancer activity against many types of cancer cells including nasopharyngeal carcinoma (NPC). However, the detailed molecular mechanism underlying this is not clearly understood. In this study, we showed that curcumin significantly inhibited the growth of NPC cells in a dose-and time-dependent manner as determined by MTT assays, while increasing apoptosis was also observed as measured by flow cytometry for the FITC-Annexin V and propidium iodide (PI) label and Hoechst 33258 staining. To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2. Furthermore, silencing of FOXO3a and p53 genes by siRNAs overcame the inhibitory effect of curcumin on cell proliferation. Silencing or blockade of p53 using siRNA or chemical inhibitor abrogated the effect of curcumin on expression of FOXO3a protein; silencing or overexpression of FOXO3a had no further effect on curcumin-induced p53 protein expression. Furthermore, blockade of ERK1/2 and exogenous expression of FOXO3a restored the effect of curcumin on growth of cells. Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a. p53 is upstream of FOXO3a, which form a regulatory loop that mediates the effect of curcumin. This study unveils a new mechanism by which curcumin inhibits the proliferation and induces apoptosis of human NPC cells.

show abstract

Section: Discussionmentioning

confidence: 85%

Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin

Tang

Zhao

et al. 2014

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…For example, curcumin can inactivate NF-κB [338], and reduce COX-2 expression [339] and downstream targets as well [338]. It promotes apoptosis through interaction with p53 [340] and by increasing caspase expression [341], and it induces cell cycle arrest [342]. In animal models curcumin prevents cancer development through reduction of TNF-α, interferon-γ (IFN-γ), and COX-2 [343].…”

Section: Low Toxicity Approachesmentioning

confidence: 99%

A multi-targeted approach to suppress tumor-promoting inflammation

Samadi

Bilsland

Georgakilas

et al. 2015

Seminars in Cancer Biology

View full text Add to dashboard Cite

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-kappaB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes.

show abstract

“…Moreover, the nuclear staining by Annexin V/PI was found to be positive, confirming the activation of apoptotic machinery [47] . Recently, several reports have confirmed the antiproliferative action of CUR in cancers of breast, pancreas and lung through the down-regulation of epidermal growth factor receptor (EGFR), which is usually highly upregulated in tumour circumstances [48] .…”

Section: Cur Can Act As An Antitumour Agentmentioning

confidence: 65%

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Moselhy¹,

Razvi²,

Hasan³

et al. 2018

pharmaceutical-sciences

View full text Add to dashboard Cite

Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

show abstract

Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway

Cited by 109 publications

References 42 publications

Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin

Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin

A multi-targeted approach to suppress tumor-promoting inflammation

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Contact Info

Product

Resources

About