Curcumin induces paraoxonase 1 in cultured hepatocytes <i>in vitro</i> but not in mouse liver <i>in vivo</i>

Schrader, Charlotte; Schiborr, Christina; Frank, Jan; Rimbach, Gerald

doi:10.1017/s0007114510004356

Cited by 24 publications

(26 citation statements)

References 17 publications

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“…As well as inducing HO1, curcumin also induces the antioxidant enzyme paraoxonase 1 (PON1). PON1 is primarily synthesized in the liver and circulates in the blood bound to HDL 110. PON1 prevents or slows down the oxidation of LDL and thus mediates anti‐atherogenic effects 111.…”

Section: Biological Activity and Molecular Targets Of Curcuminmentioning

confidence: 99%

Curcumin—From Molecule to Biological Function

et al. 2012

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Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in curry and gives curry powder its characteristic yellow color. As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mustard). Turmeric contains the curcuminoids curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Recently, the health properties (neuroprotection, chemo-, and cancer prevention) of curcuminoids have gained increasing attention. Curcuminoids induce endogenous antioxidant defense mechanisms in the organism and have anti-inflammatory activity. Curcuminoids influence gene expression as well as epigenetic mechanisms. Synthetic curcumin analogues also exhibit biological activity. This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.

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Section: Biological Activity and Molecular Targets Of Curcuminmentioning

confidence: 99%

Curcumin—From Molecule to Biological Function

et al. 2012

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“…However, dietary supplementation of female B6C3F1 mice with curcumin (500 mg/kg diet) for two weeks did not increase hepatic Pon1 mRNA and protein levels. In conclusion, curcumin may be a potent PON1 inducer in cultured cells in vitro, but not in the liver of curcumin-fed mice because of its low concentrations in vivo [54]. This low bioavailability could be due to its chemical instability at the extreme pH values found in the stomach and intestine.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Lou-Bonafonte

Gabás‐Rivera

Navarro

et al. 2017

IJMS

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Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments.

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“…verzçgert die Oxidation von LDL und vermittelt somit antiatherogene Effekte. [113,114] Analog den Effekten bei HO1 [107] und PON1 [110] lässt sich GSH [115] durch Curcumin nicht aber durch Ferulasäure induzieren (Abbildung 7). Substrate der PON sind Paraoxon und Phenylacetat, die zur Aktivitätsmessung eingesetzt werden.…”

Section: Radikalfangende Und Zelluläre Antioxidative Eigenschaften üBunclassified

“…PON1 wird vor allem in der Leber synthetisiert und zirkuliert im Blut gebunden an HDL. [110] PON1 verhindert bzw. verzçgert die Oxidation von LDL und vermittelt somit antiatherogene Effekte.…”

Section: Radikalfangende Und Zelluläre Antioxidative Eigenschaften üBunclassified

“…[112] Das Schlüsselenzym der GSH-Biosynthese ist die g-Glutamylcysteinsynthetase (gGCS), welche wiederum unter transkriptioneller Kontrolle von Nrf2 steht. [113,114] Analog den Effekten bei HO1 [107] und PON1 [110] lässt sich GSH [115] durch Curcumin nicht aber durch Ferulasäure induzieren (Abbildung 7). [99] Neben der Induktion antioxidativer Schutzsysteme wie HO1, PON1 und GSH sowie Phase-II-Enzymen [116] über Nrf2-abhängige Signalwege scheint Curcumin auch entzündungshemmende Effekte zu vermitteln (Abbildung 8).…”

Section: Radikalfangende Und Zelluläre Antioxidative Eigenschaften üBunclassified

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Curcumin – vom Molekül zur biologischen Wirkung

et al. 2012

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Curcuma (Gelbwurzel) wird traditionell als Würzmittel für Lebensmittel eingesetzt. Curcumin ist ein wichtiger Bestandteil des Currypulvers und verleiht dem Pulver seine charakteristische Farbe. Aufgrund seiner intensiven gelben Farbe wird Curcuma bzw. Curcumin (Zusatzstoff E100) auch zum Färben von Lebensmitteln (z. B. Senf) verwendet. Curcuma enthält die Curcuminoide Curcumin, Demethoxycurcumin und Bisdemethoxycurcumin. In jüngster Zeit werden vermehrt gesundheitsfördernde Eigenschaften (Neuroprotektion, Chemo‐ bzw. Krebsprävention) von Curcuminoiden diskutiert. Curcuminoide induzieren im Organismus endogene antioxidative Schutzsysteme und wirken entzündungshemmend. Curcuminoide beeinflussen die Genexpression sowie epigenetische Regulationsmechanismen. Synthetische Curcumin‐Analoga zeigen zum Teil biologische Wirkungen. Dieser Aufsatz beschreibt die Entwicklung von Curcuma vom “traditionellen” Würz‐ und Färbemittel zum “modernen” biologischen Regulator.

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Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo

Cited by 24 publications

References 17 publications

Curcumin—From Molecule to Biological Function

Curcumin—From Molecule to Biological Function

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

Curcumin – vom Molekül zur biologischen Wirkung

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