Curcumin—From Molecule to Biological Function

Esatbeyoglu, Tuba; Huebbe, Patricia; Ernst, Insa M. A.; Chin, Dawn; Wagner, Anika E.; Rimbach, Gerald

doi:10.1002/anie.201107724

Cited by 735 publications

(572 citation statements)

References 244 publications

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“…The content of turmeric curcuminoids may vary between 2 and 9%, depending on geographic conditions (Esatbeyoglu et al, 2012). In general, starch is the component present in greater proportion, as observed in this study by scanning electron microscopy.…”

Section: Resultssupporting

confidence: 59%

Physical and chemical characteristics and drying kinetics of turmeric (Curcuma longa L.)

Lima¹,

Silva²,

Plácido³

et al. 2017

Afr. J. Agric. Res.

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This study aimed to characterize the physical and chemical composition, antioxidant activity, essential oil yield, drying kinetics and fit to mathematical models, color parameters, particle size and scanning electron microscopy of fresh turmeric rhizomes (Curcuma longa L.). The physical and chemical composition of turmeric showed technological interest, with standards consistent with those reported in the literature. The essential oil has potential for further studies and applicability in food products, as well as use as preservative with antioxidant action. The Midilli model was the one that best fit the drying kinetics of turmeric. The results also allowed analyzing soluble, insoluble and total fibers and SEM, and it was found that there is perspective of using this raw material for the development of new products.

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Section: Resultssupporting

confidence: 59%

Physical and chemical characteristics and drying kinetics of turmeric (Curcuma longa L.)

Lima¹,

Silva²,

Plácido³

et al. 2017

Afr. J. Agric. Res.

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“…Curcumin, or turmeric, which is derived from the root of the plant Curcuma longa Linn, has been used as a treatment for inflammatory conditions in Ayurvedic medicine for centuries [8] . It has been reported that curcumin attenuates neurobiological deficits in animal models of different neurological disorders, including Parkinson's disease [9] , brain trauma [10] , ischemic stroke [11] , and subarachnoid hemorrhage (SAH) [12] .…”

Section: Introductionmentioning

confidence: 99%

Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression

et al. 2015

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Aim: Aquaporins (AQPs) are the water-channels that play important roles in brain water homeostasis and in cerebral edema induced by brain injury. In this study we investigated the relationship between AQPs and a neuroprotective agent curcumin that was effective in the treatment of brain edema in mice with intracerebral hemorrhage (ICH). Methods: ICH was induced in mice by autologous blood infusion. The mice immediately received curcumin (75, 150, and 300 mg/kg, ip). The Rotarod test scores, brain water content and brain expression of AQPs were measured post ICH. Cultured primary mouse astrocytes were used for in vitro experiments. The expression of AQP1, AQP4 and AQP9 and NF-κB p65 were detected using Western blotting or immunochemistry staining. Results: Curcumin administration dose-dependently reduced the cerebral edema at d 3 post ICH, and significantly attenuated the neurological deficits at d 5 post ICH. Furthermore, curcumin dose-dependently decreased the gene and protein expression of AQP4 and AQP9, but not AQP1 post ICH. Treatment of the cultured astrocytes with Fe 2+ (10-100 µmol/L) dose-dependently increased the expression and nuclear translocation of NF-κB p65 and the expression of AQP4 and AQP9, which were partly blocked by co-treatment with curcumin (20 µmol/L) or the NF-κB inhibitor PDTC (10 µmol/L). Conclusion: Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-κB pathway and subsequently the expression of AQP4 and AQP9. Curcumin may serve as a potential therapeutic agent for ICH.

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“…[1][2][3] However, its medical benefits are restricted by low aqueous solubility, poor intestinal absorption, and chemical instability in the physiological environment, resulting in low bioavailability. 4) Many approaches have been developed to overcome these intrinsic barriers to bioavailability, including co-administration of CUR with inhibitors of glucuronidation, nano-formulations with lipids and polymers, amorphous solid dispersions, and prodrugs by conjugation.…”

Section: Curcuminmentioning

confidence: 99%

Improvement of the Solubility and Intestinal Absorption of Curcumin by <i>N</i>-Acyl Taurates and Elucidation of the Absorption-Enhancing Mechanisms

Kawamura

Sato

et al. 2017

Biological & Pharmaceutical Bulletin

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In this study, the effects of N-acyl taurates (NATs) on the intestinal absorption of curcumin (CUR), a water-insoluble and poorly absorbed compound, were examined in rats. Sodium methyl lauroyl taurate (LMT) and sodium methyl cocoyl taurate (CMT) were the most effective in increasing the solubility and intestinal absorption of CUR. The intestinal membrane toxicity of the NATs was also evaluated by measuring the activity of lactate dehydrogenase (LDH), a toxicity marker. NATs did not increase the activity of LDH, suggesting that they may be safely administered orally. We further elucidated the absorption-enhancing mechanisms of NATs by using Caco-2 cells. In cellular transport studies, LMT and CMT reduced the transepithelial electrical resistance value of Caco-2 cells and increased the transport of 5(6)-carboxyfluorescein and CUR. Hence, the intestinal absorption enhancement by LMT and CMT was attributed to the synergistic effect of higher solubility and greater permeability of the cell layer towards CUR in the presence of the surfactants. In summary, co-administration of CUR with either LMT or CMT is a simple and effective method to enhance oral delivery of CUR.

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Curcumin—From Molecule to Biological Function

Cited by 735 publications

References 244 publications

Physical and chemical characteristics and drying kinetics of turmeric (Curcuma longa L.)

Physical and chemical characteristics and drying kinetics of turmeric (Curcuma longa L.)

Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression

Improvement of the Solubility and Intestinal Absorption of Curcumin by <i>N</i>-Acyl Taurates and Elucidation of the Absorption-Enhancing Mechanisms

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