Curcumin in decellularized goat small intestine submucosa for wound healing and skin tissue engineering

Abstract

Biomaterials derived from extracellular matrices (ECMs) were extensively used for skin tissue engineering and wound healing. ECM is a complex network of biomolecules (e.g., proteins), which provide organizational support to cells for growth. Thus, ECM could be an ideal biomaterial for fabricating the scaffold. However, oxidative stress and biofilm formation at the wound site remains a major challenge that could be neutralized using herbal ingredients (e.g., curcumin). In this study, ECM was extracted from the biowaste of the goat abattoir by using decellularization. The goat small intestine submucosa (G‐SIS) is decellularized to obtain the decellularized G‐SIS (DG‐SIS) and curcumin (in different concentrations) was incorporated in the DG‐SIS to fabricate curcumin‐embedded DG‐SIS scaffolds. Changes brought by increasing the concentrations of the curcumin in DG‐SIS were observed in various properties, including free radical scavenging and antibacterial properties. Results depicted that the scaffolds are porous, biodegradable, biocompatible, antibacterial, and hydrophilic and showed sustained release of curcumin. Besides, it showed free radicals scavenging property. The porosity and hydrophilicity of the scaffolds were decreased with an increase in the curcumin content. However, biodegradability, free radical scavenging, biocompatibility, and antibacterial properties of the scaffolds increased with an increase in the curcumin content. The DG‐SIS scaffold containing 1 wt % of curcumin may be a potential biomaterial for wound‐healing and skin tissue engineering.

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Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review

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Decellularized Tissues for Wound Healing: Towards Closing the Gap Between Scaffold Design and Effective Extracellular Matrix Remodeling

“…The human placenta provides oxygen and nutrients to the fetus during pregnancy and eliminates waste products from its blood system. Decellularized placenta consists of various structural and adhesion proteins such as collagen (I, IV, VII, and XVII), elastin, LM, as well as proteoglycans, which serve as reservoir for many growth factors, including IGF, EGF, PDGF, FGF, VEGF and TGF-β (Choi et al, 2013;Singh et al, 2022). When dECM obtained from human placenta was used to treat rat fullthickness wounds, a well-structured basement membrane was deposited, and an increase in keratinocyte proliferation and differentiation was observed, which led to new epithelial tissue architecture that was very similar to original skin (Choi et al, 2013).…”