Curcumin for the Management of Periodontal Diseases: A Review

Abstract

: Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.

Design, synthesis, and evaluation of mono‐carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis

“…The anti-inflammation and antioxidant properties of natural curcumin, and its role as host response modulator to reduce periodontal inflammation has been extensively reviewed. 28 However, its clinical application as a potential orally administrated agent is limited by the poor pharmaceutical activity such as low absorption and rapid elimination. 11 Considerable efforts have been made to improve the pharmaceutical activity by synthesizing the curcumin analogues.…”

Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

“…An extensive literature search was performed using the PubMed, Cochrane Library, and Web of Science databases to summarize the currently available knowledge and answer the aforementioned clinical question by isolating randomized controlled trials (RCTs) investigating the effects of antioxidants with periodontal treatment in patients with diabetes prior to 6 April 2021. The search terms related to antioxidants were set according to the previous studies [ 43 , 44 , 45 , 46 , 47 , 48 ]. The search terms used in PubMed are listed below:…”

“…An extensive literature search was performed using the PubMed, Cochrane Library, and Web of Science databases to summarize the currently available knowledge and answer the aforementioned clinical question by isolating randomized controlled trials (RCTs) investigating the effects of antioxidants with periodontal treatment in patients with diabetes prior to 6 April 2021. The search terms related to antioxidants were set according to the previous studies [43][44][45][46][47][48] A similar search strategy was applied to all the databases. Additional electronic searches were performed in the Journal of Periodontology, Journal of Clinical Periodontology, Journal of Periodontal Research, and Antioxidants, to increase the likelihood of identifying relevant papers [49].…”

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

“…The buccal route for systemic drug delivery relies on transmucosal absorption of drug molecules through mucosal membranes lining the cheeks [32]. In addition to systemic CUR delivery, the buccal film of the CUR-CHI nanoplex can also have applications in local CUR administration in the oral cavity, as CUR is known to be effective in treating various periodontal diseases [33]. Unlike fast-dissolving oral thin film in which the drug payload is released almost instantaneously [34], the buccal film in the present work was prepared using mucoadhesive polysaccharides to facilitate sustained CUR release known to be ideal for its bioavailability enhancement [35].…”