Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma

Dendrimer nanoparticles for colorectal cancer applications

“…In a recent work, Aliboland et al [12] encapsulated gold (Au) NPs inside PAMAM dendrimer NPs. The aim of this study was to investigate the theranostic capability of curcumin-loaded dendrimer-gold hybrid structures (Figure -4B).…”

“…The obtained results confirmed higher cellular uptake, internalization and cytotoxicity of Apt-PEG-AuPAMAM-CUR in comparison with PEG-AuPAMAM-CUR in C26 and HT29 colorectal cancer cell lines. Moreover, the system worked as an effective anti-tumor therapy and accurate computed tomography imaging of C26 tumor-bearing mice due to gold accumulation [12].…”

“…Moreover, it is possible to incorporate targeting moieties selective for cancer cell biomarkers, which improves even more the selectivity and specificity of the treatment [8]. The main types of targeting moieties that are used for decorating and targeting NPs are: i) Antibodies [9]; ii) Peptide-based targeting [10]; iii) Small molecule-based targeting [11]; and iv) Aptamer-based targeting [12,13]. Figure 1 -Rationale for nanomedicine approach in cancer-therapy.…”

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

“…AuNPs have been reported that were functonalized with the MUC‐1 aptamer, which targets the mucin 1 (MUC‐1) receptor . Among the reported AuNPs, an imaging agent with an additional silica shell was used to target human breast cancer MDA‐MB‐468 cells with MUC‐1 expression (Figure 13c).…”

“…Among the reported AuNPs, an imaging agent with an additional silica shell was used to target human breast cancer MDA‐MB‐468 cells with MUC‐1 expression (Figure 13c). Similarly, to image and treat colon adenocarcinoma in vivo (C26‐xenograft mouse model), curcumin (fluorescent tracker) was entrapped to target both HT29 and C26 cancer cells with MUC‐1 receptor . 5'‐end thiolated oligonucleotides containing AS1411 aptamer were coated onto the outside of the AuNPs gold lattice, and silver nanoclusters (AgNCs) with DNA template were introduced by complementary base pairing to form photoluminescent gold–silver nanocomposite localizing in the nucleus of HeLa (human cervix cancer) cells with nucleolin protein expressing for theranostics (Figure 13d).…”