Curcumin entrapped gelatin/ionically modified bacterial cellulose based self-healable hydrogel film: An eco-friendly sustainable synthesis method of wound healing patch

Khamrai, Moumita; Banerjee, Shib Shankar; Paul, Saikat; Samanta, Sutanu; Kundu, Patit Paban

doi:10.1016/j.ijbiomac.2018.10.196

Cited by 97 publications

(56 citation statements)

References 30 publications

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“…For wound dressings, curcumin was applied mainly with plant-derived and chemically modified nanocellulose, and, in rare cases, in combination with bacterial cellulose. In a recent study, curcumin was entrapped into a composite containing gelatin and ionically modified self-assembled bacterial cellulose and showed wound healing activity and antimicrobial activity [269].…”

Section: Nanocellulose In Wound Healingmentioning

confidence: 99%

Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing

et al. 2019

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Nanocellulose is cellulose in the form of nanostructures, i.e., features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, found in bacterial cellulose; nanofibers, present particularly in electrospun matrices; and nanowhiskers, nanocrystals, nanorods, and nanoballs. These structures can be further assembled into bigger two-dimensional (2D) and three-dimensional (3D) nano-, micro-, and macro-structures, such as nanoplatelets, membranes, films, microparticles, and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluconacetobacter), plants (trees, shrubs, herbs), algae (Cladophora), and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology, and biomedical applications, namely for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

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Section: Nanocellulose In Wound Healingmentioning

confidence: 99%

Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing

et al. 2019

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“…The in vivo wound healing tests of the curcumin entrapped nanofilms on incision and excision wounds made on the rat models revealed a significant wound closure when compared to the untreated wounds [ 85 ]. Khamrai et al formulated gelatin/ bacterial cellulose-based hydrogel films entrapped with curcumin [ 86 ]. The self-healing capability of the wound dressings was significant.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

“…The in vitro wound healing analysis showed that the hydrogels films loaded with a higher curcumin loading accelerated the cell migration and proliferation. The curcumin-loaded hydrogel films healed the wound completely when compared to the references that healed up to 59% [ 86 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…For wound dressings, curcumin was applied mainly with plant-derived and chemically-modified nanocellulose, and, in rare cases, in combination with bacterial cellulose. In a recent study, curcumin was entrapped into a composite containing gelatin and ionically modified self-assembled bacterial cellulose, and showed wound healing activity and antimicrobial activity [245].…”

Section: Nanocellulose As a Carrier For Cell Delivery Into Skin Defectsmentioning

confidence: 99%

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

Bacakova¹,

Pajorová²,

Bačáková³

et al. 2018

Preprint

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Nanocellulose is cellulose in the form of nanostructures, i.e. features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, e.g. in bacterial cellulose; nanofibers, e.g. in electrospun matrices; nanowhiskers and nanocrystals. These structures can be further assembled into bigger 2D and 3D nano-, micro- and macro-structures, such as nanoplatelets, membranes, films, microparticles and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluonacetobacter), plants (trees, shrubs, herbs), algae (Cladophora) and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology and biomedical applications, e.g. for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

show abstract

Curcumin entrapped gelatin/ionically modified bacterial cellulose based self-healable hydrogel film: An eco-friendly sustainable synthesis method of wound healing patch

Cited by 97 publications

References 30 publications

Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing

Versatile Application of Nanocellulose: From Industry to Skin Tissue Engineering and Wound Healing

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

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