Curcumin enhances the radiosensitivity of renal cancer cells by suppressing NF-κB signaling pathway

Li, Gang; Wang, Ziming; Chong, Tie; Yang, Jie; Li, Hongliang; Chen, Haiwen

doi:10.1016/j.biopha.2017.07.148

Cited by 45 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 The anti-cancer compounds from Chinese herbal medicine (CHM). The popular anti-cancer compounds in CHM presented as a "word cloud", in which the size of each name is proportional to the number of publications of the compounds (NF-κB), signal transducer and activator of transcription and cell cycle-related proteins [36][37][38][39][40][41][42][43][44][45][46]. Curcumin is shown to induce anti-cancer activities through the disruption of mitochondrial membrane potential and blockade at G2/M phase of the cell cycle in human epidermoid carcinoma A-431 cells [47].…”

Section: Curcuminmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

View full text Add to dashboard Cite

Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

show abstract

Section: Curcuminmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

View full text Add to dashboard Cite

show abstract

“…30 Curcumin sensitizes renal cancer cells to radiation through suppressing NF-κB signal cascades. 31 Curcumin promotes the radiosensitivity of prostate cancer cells partly via activating miR-143 and miR-143-evoked autophagy decline, implying curcumin-induced radiosensitivity has involvement with autophagic events. 32 There is evidence that curcumin-mediated the inhibition of PI3K/AKT/mTOR signaling pathway contributes to the activation of autophagy and downstream the enhancement of radiosensitivity of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Effect of combination of curcumin and GLUT‐1 AS‐ODN on radiosensitivity of laryngeal carcinoma through regulating autophagy

Dai

Zhou

et al. 2020

Head & Neck

View full text Add to dashboard Cite

Background This study is to explore the role of curcumin and GLUT‐1 antisense oligodeoxynucleotides (AS‐ODN) on autophagy modulation‐initiated radiosensitivity. Methods BALB/c mice were employed to establish xenograft model using Tu212 cell. The expression of autophagy‐ and apoptosis‐related proteins was determined by WB. Autophagosome was observed under transmission electron microscope. Apoptosis of tumor tissue were detected by TUNEL staining. Results Combinations of curcumin and GLUT‐1 AS‐ODN with 10 Gy inhibited the tumor growth by inducing apoptosis of laryngeal cancer cells followed with the enhancement of autophagy. 3‐MA also had a promotion effect on irradiation‐mediated growth inhibition possibly by depressing PI3K and on curcumin/GLUT‐1 AS‐ODN‐mediated growth inhibition potentially by regulating autophagic events. Of note, a de‐escalation of radiotherapy dose (5 Gy) along with curcumin, GLUT‐1 AS‐ODN or 3‐MA produced a stronger effect than high dosage of radiotherapy (10 Gy) alone. Conclusions Curcumin and GLUT‐1 AS‐ODN improve the radiosensitivity of laryngeal carcinoma through regulating autophagy and inducing apoptosis.

show abstract

“…However, the effect and mechanism of allicin on the sensitivity of CRC radiotherapy have not been confirmed. Recent studies have reported that the radiotherapy resistance is closely related to the abnormal expression of PI3K/Akt, Wnt/ß‐catenin, or NF‐κB signaling pathways (Bao, Zhou, Lu, Fan, & Huang, 2015; Cojoc et al., 2015; Li et al., 2017; Ren, Li, Li, Zhang, & Han, 2017; Wang, Liu, Shan, & Wang, 2017). Among these, the activation of NF‐κB is considered to play a vital role to inhibit apoptosis and promote proliferation in tumor cell.…”

Section: Introductionmentioning

confidence: 99%

Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF‐κB signaling pathway

Huang

et al. 2020

Journal of Food Science

View full text Add to dashboard Cite

Radioresistance is an important factor affecting the radiotherapy effect of colorectal cancer (CRC). Allicin is a versatile sulfur‐containing organic compound extracted from garlic (Allium sativum L.), which has many pharmacological effects. However, the effect of allicin on the sensitivity of CRC radiotherapy has not been confirmed. The present study is to observe the radiosensitivity effects of allicin and to explore its mechanism in CRC radiotherapy. The proliferation inhibition effects of allicin combined with X‐ray radiotherapy in HCT116 cells were measured by growth curve of cell and colony formation assays. The cell apoptosis was detected by Hoechst 33258 nucleus staining assay. The migration ability of cells was detected by Transwell chamber migration assay. The animal model of CRC was established in BALB/c mice via transplantation of CT26 cell, and the radiosensitization effect of allicin on CRC was detected in vivo. The mRNA expressions of NF‐κB, IKKβ, and IκBα were analyzed by reverse transcription‐polymerase chain reaction (RT‐PCR). The protein expressions of NF‐κB, p‐NF‐κB, IKKβ, p‐IKKβ, IκBα, and p‐IκBα were detected by western blotting. Our results showed that allicin improves the sensitivity of X‐ray radiotherapy in CRC, and its mechanism may be associated with inhibition of NF‐κB signaling pathway. These findings suggest that allicin may be used as a potential sensitizer for tumor radiotherapy in the clinic.

show abstract

Curcumin enhances the radiosensitivity of renal cancer cells by suppressing NF-κB signaling pathway

Cited by 45 publications

References 32 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Effect of combination of curcumin and GLUT‐1 AS‐ODN on radiosensitivity of laryngeal carcinoma through regulating autophagy

Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF‐κB signaling pathway

Contact Info

Product

Resources

About