Curcumin enhances non-inflammatory phagocytic activity of RAW264.7 cells

Bisht, Kavita; Choi, Woo Hyuck; Park, Shin Y.; Chung, Moon-Koo; Koh, Won‐Gun

doi:10.1016/j.bbrc.2008.12.135

Cited by 40 publications

(22 citation statements)

References 36 publications

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“…3 were all significantly (p<0.01) over-represented in the first order curcumin network, compiled from data validated in multiple model organisms. The ontology map of molecular interactions of curcumin showed that it has been implicated in pathways regulating phagocytosis of microglia, activation of glia, differentiation of phagocytosis, recruitment of phagocytes [51], [52] and proliferation of immune cells [53]. Curcumin has been reported to interact with numerous molecular targets, including growth factors, inflammatory cytokines, transmembrane receptors, transcription factors, protein kinases and regulatory enzymes [54].…”

Section: Resultsmentioning

confidence: 99%

Low-Dose Curcumin Stimulates Proliferation, Migration and Phagocytic Activity of Olfactory Ensheathing Cells

et al. 2014

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One of the promising strategies for neural repair therapies is the transplantation of olfactory ensheathing cells (OECs) which are the glial cells of the olfactory system. We evaluated the effects of curcumin on the behaviour of mouse OECs to determine if it could be of use to further enhance the therapeutic potential of OECs. Curcumin, a natural polyphenol compound found in the spice turmeric, is known for its anti-cancer properties at doses over 10 µM, and often at 50 µM, and it exerts its effects on cancer cells in part by activation of MAP kinases. In contrast, we found that low-dose curcumin (0.5 µM) applied to OECs strikingly modulated the dynamic morphology, increased the rate of migration by up to 4-fold, and promoted significant proliferation of the OECs. Most dramatically, low-dose curcumin stimulated a 10-fold increase in the phagocytic activity of OECs. All of these potently stimulated behavioural characteristics of OECs are favourable for neural repair therapies. Importantly, low-dose curcumin gave a transient activation of p38 kinases, which is in contrast to the high dose curcumin effects on cancer cells in which these MAP kinases tend to undergo prolonged activation. Low-dose curcumin mediated effects on OECs demonstrate cell-type specific stimulation of p38 and ERK kinases. These results constitute the first evidence that low-dose curcumin can modulate the behaviour of olfactory glia into a phenotype potentially more favourable for neural repair and thereby improve the therapeutic use of OECs for neural repair therapies.

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Section: Resultsmentioning

confidence: 99%

Low-Dose Curcumin Stimulates Proliferation, Migration and Phagocytic Activity of Olfactory Ensheathing Cells

et al. 2014

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“…Although curcumin completely blocked LPS mediated NO production in RAW264.7 cell line, it enhanced the phagocytosis of fluorescent beads and the surface expression of CD14. The enhancement of pahgocytic activity and the surface expression of CD14 followed a similar pattern, however no direct role of curcumin mediated enhanced CD14 surface expression was described for the phagocytic capcity [51]. Previously, an independent study had also shown a significant increase in Mϕ phagocytic activity in curcumin-treated animals.…”

Section: Immunomodulatory Effect Of Curcumin On Monocytes and Macrophmentioning

confidence: 88%

Immunomodulatory and therapeutic activity of curcumin

Srivastava

Singh²,

Dubey

et al. 2011

International Immunopharmacology

192

108

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“…In addition, curcumin has some immunosuppressive activities (11) including expression of cytokines such as IL-1 and TNF-α (12,13). On the other hand, curcumin enhanced phagocytic activity of macrophages (14). In our study, we compared the antibacterial effects of five different types of curcumin.…”

Section: Introductionmentioning

confidence: 99%

Effects of curcumin on Helicobacter pylori infection

Větvička¹,

Větvičková²,

Fernández-Botrán³

2016

Ann. Transl. Med.

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Background: Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects on Helicobacter pylori (H. pylori) infection have been repeatedly confirmed both in animal and human models. This study directly compared five different samples to evaluate if the effects are general or if they differ among samples.Methods: Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti-H. pylori antibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration.In addition, we evaluated the effects on biofilm production and antibacterial antibody response.Results: In all tests, one sample (Sabinsa) was consistently the most active.Conclusions: All curcumin samples showed some anti-H. pylori effects, but only some of the tested samples had significant activity.

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Curcumin enhances non-inflammatory phagocytic activity of RAW264.7 cells

Cited by 40 publications

References 36 publications

Low-Dose Curcumin Stimulates Proliferation, Migration and Phagocytic Activity of Olfactory Ensheathing Cells

Low-Dose Curcumin Stimulates Proliferation, Migration and Phagocytic Activity of Olfactory Ensheathing Cells

Immunomodulatory and therapeutic activity of curcumin

Effects of curcumin on Helicobacter pylori infection

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