Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK

Bai, Qing-Xian; Zhang, Xiaoyan

doi:10.3390/ijms13044831

Cited by 31 publications

(20 citation statements)

References 17 publications

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“…These findings are similar to those of previous studies with myeloma cell lines (U266 and H929) using curcumin and a less potent immunomodulatory drug, i.e. thalidomide [10] and bortezomib [11] respectively. The H929 cell line was chosen for this study because it harbours the t(4; 14) translocation, whereas the U266 cell line carries a t(11; 14) translocation [18] .…”

Section: Discussionsupporting

confidence: 91%

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Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells

Wong¹,

Golombick

Diamond³

et al. 2013

J Hemat Malig

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Background: Curcumin, the active component of the Curcuma longa plant, has been shown to potentiate the effect of the immunomodulatory drugs (IMiDs) thalidomide and Bortezomib against human myeloma cell lines and a nude mice model. Its effect on the other IMid, lenalidomide, has not been evaluated. This study aims to investigate the mechanism of action of curcumin and its potential ability to positively interact with lenalidomide.Method: we designed an in-vitro study to investigate the cytotoxic and chemo-sensitising effects of curcumin alone and in combination with lenalidomide on the human myeloma H929 cell line. Results:Incubation of H929 cells with curcumin (30M) or lenalidomide (2.5 mM) for 3 days resulted in 26.35% (±1.06) and 30.81%(±2.98) apoptotic cells respectively. When 30 M curcumin was combined with 2.5 mM lenalidomide, 50.4% (±3.37) apoptotic cells were detected by flow cytometry and the increase was significant compared to either curcumin alone or lenalidomide alone (anova p = 0.0026). Furthermore, gene analysis studies show that curcumin enhances the cytotoxic effect of lenalidomide via suppression of the cereblon and multi-drug resistant genes. Conclusion:Curcumin exerts a cytotoxic effect additive to that of lenalidomide on H929 myeloma cells, and it also enhances the chemo-sensitizing effects of this agent.

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Section: Discussionsupporting

confidence: 91%

“…Bai & Zhang [11] have shown that curcumin enhances the cytotoxic effects of bortezomib in a human multiple myeloma cell line.…”

mentioning

confidence: 99%

Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells

Wong¹,

Golombick

Diamond³

et al. 2013

J Hemat Malig

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“…Figure 2 depicts the hierarchical cluster analysis of the obtained gene expression patterns. Previous studies highlighted that treatment with curcumin and bortezomib activated JNK signaling in multiple myeloma cells [ 33 ]. In agreement with that, we observed increased expression of JUN (jun protooncogene), a target of JNK (MAPK8, mitogen-activated protein kinase 8), following both curcumin and bortezomib treatment, and this overexpression was enhanced by their combined use.…”

Section: Resultsmentioning

confidence: 99%

Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Nagy¹,

Feher²,

Szebeni³

et al. 2015

BioMed Research International

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Combination therapy of bortezomib with other chemotherapeutics is an emerging treatment strategy. Since both curcumin and bortezomib inhibit NF-κB, we tested the effects of their combination on leukemia cells. To improve potency, a novel Mannich-type curcumin derivative, C-150, was synthesized. Curcumin and its analogue showed potent antiproliferative and apoptotic effects on the human leukemia cell line, HL60, with different potency but similar additive properties with bortezomib. Additive antiproliferative effects were correlated well with LPS-induced NF-κB inhibition results. Gene expression data on cell cycle and apoptosis related genes, obtained by high-throughput QPCR, showed that curcumin and its analogue act through similar signaling pathways. In correlation with in vitro results similar additive effect could be obsereved in SCID mice inoculated systemically with HL60 cells. C-150 in a liposomal formulation given intravenously in combination with bortezomib was more efficient than either of the drugs alone. As our novel curcumin analogue exerted anticancer effects in leukemic cells at submicromolar concentration in vitro and at 3 mg/kg dose in vivo, which was potentiated by bortezomib, it holds a great promise as a future therapeutic agent in the treatment of leukemia alone or in combination.

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“…It has attracted much interest due to its low toxicity, proven pharmacological safety, and favorable biological activity, which includes lowering of blood fat as well as anti-inflammatory and antitumor effects. Its antitumor effects, both alone and combined with other chemotherapeutics, are widely supported by recent studies, and one of these has shown that curcumin can inhibit the proliferation of malignant plasma cells (myeloma cells) and induce apoptosis [7]. Therefore, we hypothesized that curcumin and bortezomib in combination could have a synergistic effect on myeloma cells.…”

Section: Introductionmentioning

confidence: 94%

Curcumin Enhances Bortezomib Treatment of Myeloma by Inhibiting Heat Shock Protein 90 Expression

Fang¹,

Jh²,

Xw³

et al. 2015

Trop. J. Pharm Res

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Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK

Cited by 31 publications

References 17 publications

Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells

Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells

Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Curcumin Enhances Bortezomib Treatment of Myeloma by Inhibiting Heat Shock Protein 90 Expression

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