Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFκB

Bachmeier, Beatrice E.; Mohrenz, Isabelle V.; Mirisola, Valentina; Schleicher, Erwin; Romeo, Francesco; Höhneke, Clara; Jochum, Marianne; Nerlich, Andreas G.; Pfeffer, Ulrich

doi:10.1093/carcin/bgm248

Cited by 199 publications

(169 citation statements)

References 38 publications

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“…EGFR is overexpressed in numerous types of head and neck cancer, and molecular therapies targeting the EGFR/AKT signaling cascade the therapeutic efficacy of standard platinum-based chemotherapy (90). In addition, the expression levels of multiple NF-κB-regulated gene products, including IL-6, IL-8, MMP-9, COX-2, CCL2 and Bcl-XL, were reduced (86,(91)(92)(93)(94)(95).…”

Section: Head and Neck Cancermentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

246

183

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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Section: Head and Neck Cancermentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

246

183

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Section: Potential Anti-migration Anti-invasion and Anti-colony Formmentioning

confidence: 99%

“…Bachmeier et al (25) and Killian et al (26) reported that curcumin prevents NF-ĸB activation by inhibiting phosphorylation and degradation of IĸBα. Curcumin is also shown to inhibit the activation of p65 (one of the NF-ĸB transcription factor family) in estrogen receptor (ER)-negative breast cancer cells (25) and in prostate cancer cells (26). Singh et al showed that curcumin inhibits NF-ĸB activation pathway in the signal transduction cascade of NF-ĸB activation before the IĸBα phosphorylation but after the point at which signals transduced by various stimuli converge (27).…”

Section: Potential Anti-migration Anti-invasion and Anti-colony Formmentioning

confidence: 99%

“…It has been shown that CXCL1 is able to promote migration of breast cancer cells in vitro (35). Bachmeier et al have identified CXCL1 and -2 expression as the major targets of anti-cancer activity of curcumin in a breast cancer cell line (25). Their research demonstrated that curcumin down-regulates mRNA expression and protein secretion of CXCL1 and -2 in a metastatic breast cancer cell line (MDA-MB-231).…”

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confidence: 99%

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Molecular Mechanisms of Anti-metastatic Activity of Curcumin

Deng

Verron

Rohanizadeh

2016

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Abstract. Cancer is the leading cause of death worldwide. Although cancer occurs as a localized disease, its morbidity and mortality rates remain high due to the ability of cancer cells to break-off from the primary tumor and spread to distant organs. Currently, chemotherapy is the main treatment for cancer; however, the increase in proportion of drug-resistant cancer cells and unpleasant side-effects of chemotherapy are still the major challenges in cancer therapy. Curcumin is a natural polyphenol compound and the main bioactive constituent of Indian spice turmeric, widely used in Indian and Chinese medicines. Curcumin has well-known therapeutic actions, including antiinflammatory, anti-microbial, anti-oxidant and anti-cancer properties. Curcumin induces cancer cell apoptosis through regulating various signaling pathways and arresting tumor cell cycle. Curcumin's therapeutic/ preventative actions on metastatic cancers have not been yet fully understood and studied. The present review explores the potential anti-metastatic mechanisms of curcumin, including inhibition of transcription factors and their signaling pathways (e.g., inflammatory cytokines (e.g., CXCL1, CXCL2, multiple proteases (e.g., uPA, MMPs), multiple protein kinases (e.g., MAPKs, FAK), regulation of miRNAs (e.g., miR21, miR181b) and heat shock proteins (HLJ1). In addition, possible synergistic actions of combination therapy of curcumin with current chemotherapies are discussed in this review.Despite all recent advances in oncology, cancer is still one of the deadliest diseases around the world (1). Cancer occurs as a localized disease but can spread to distant organs through migration, invasion and metastasis (2). Metastatic cancer is one of the major causes of death in cancer patients. Metastasis is a complex process involving multiple steps: (i) local migration through degrading basement membrane and extracellular matrix (ECM), (ii) intravasation into blood and/or lymphatic vessels, (iii) circulating to the target organ site, (iv) extravasation into target organ tissue and, finally, (v) multiplication in the target organ (2, 3). These steps are mediated by various factors, including growth factors, proteolysis degradation of extracellular matrix, cell-cell adhesion, cytoskeleton remodeling and changes of genes' expressions (2, 3). Metastasis is a non-random process that means each metastatic cancer type has its own preferred site of metastasis. For example, breast cancer cells preferentially metastasize to regional lymph nodes, liver, lungs and bone (4). Nowadays, there are different therapeutic approaches available for patients with metastatic cancers, including surgery, radiotherapy and chemotherapy. Chemotherapy remains the main treatment modality for cancer patients because of its ability of preventing invasion and metastasis. However, the morbidity and mortality rates in patients with metastatic cancer still remain high since current chemotherapy agents fail to selectively and effectively kill cancer cells without destroying normal ce...

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“…Furthermore, curcumin inhibited migration of MDA-MB-231 cells through the down regulation of protein expression of the transcription factor, NFκB (Chiu & Su, 2009). Lastly, curcumin also reduced the expression of the two prometastatic cytokines, CXCL1 and -2, which in turn reduces expression of the chemotactic receptor CXCR4 along with other metastasispromoting genes (Bachmeier et al, 2008). The anti-metastatic effect of curcumin has also been studied in various in vivo models.…”

Section: Curcuminmentioning

confidence: 99%