Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide

A Review on Cuminosides Nanomedicine-: Pharmacognostic approach to Cancer therapeutics

“…Recent investigations also rely on transmission electron microscopy to further validate cuminosides nanoformulations cellular uptake (internalization). 41,51 These investigations provide clear evidence of the presence of nanoparticle internalization at higher magnification. Another convenient method established for the determination of cellular uptake is Prussian blue staining.…”

“…For example, polyvinyl alcohol) (PVA) coated PLGA nanoformulations of cuminosides whose particle size varied between~560 to 76 nm (6 formulations) have shown distinctly different uptake patterns. 41 (Table 1) The uptake is continuously increased with a decrease in particle size. This is evidence that low particle size is more easily and highly endocytosized than higher particle size.…”

“…52 The most much of the time used estimation system is softening nanoparticles up natural dissolvable which brings about an exact cuminosides typified measurement. 41,50 It is fascinating to note that numerous cuminosides nanoformulations beforehand reported has accomplished a stacking limit up to 25 wt./wt. % with 70-99% embodiment productivity.…”

“…However, the targeting specificity of cuminosides nanoformulations towards cancer cells can be improved via antibody, peptide, penetrating ligand or aptamer conjugation. 15 After exposure of cuminosides nanoformulations to cancer cells, many nanoparticles were localized in the cytoplasm and inside or around the nucleus, 41,51 longer periods of exposure drastically changed the morphology (e.g., cell lysis and loss of spindle shape) of cancer cells and observed cell debris. This type of behavior is highly dependent upon typical physico- chemical properties such as amorphous, crystalline, particle size and morphology and surface charge of the nanoformulations.…”

“…Recent studies published from our group have demonstrated similar apoptosis characteristics with PLGA, CD assembly, cellulose, magnetic and dendrimer nanoformulations of cuminosides. 41,50 Excessive lysosomal activity or production of vacuoles is responsible for active apoptosis induction in cancer cells by cuminosides nanoformulations as demonstrated by transmission electron microscopy (TEM) analysis. 50,[53][54][55] This activity is infrequently observed with free cuminosides.…”