A Review on Cuminosides Nanomedicine-: Pharmacognostic approach to Cancer therapeutics

Pradhan, Debasish; Tripathy, Gitanjali; Pradhan, Rakesh Kumar; Dasmohapatra, Toffa

doi:10.5530/jyp.2016.2.2

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…However, many studies showed that Hematite (α-Fe 2 O 3 ) may induce genotoxicity and cytotoxicity in cancer and normal cell lines (Susan et al, 2009). Physical and chemical properties of hematite (α-Fe 2 O 3 ), including surface chemistry, weight, size distribution, shape, particle morphology, particle composition, coating/capping, agglomeration, dissolution rate, solution particle reactivity, efficiency of ion release, type of cell, and finally type of reducing agents used for synthesis, are essential elements in determining cytotoxicity (Pradhan et al, 2016a). In the present study, the phytochemicals present in the extract of B. monosperma flower are, namely glycosides and flavonoids, which act as reducing as well as a capping agent and help in stabilizing the nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative and cytotoxic activity of Hematite (-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

Behera¹,

Pradhan²,

Samantaray³

et al. 2020

Afr. J. Pharm. Pharmacol.

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Silver nanoparticles (Hematite (α-Fe 2 O 3 ) have been used as an antimicrobial and as disinfectant. Nevertheless, there is limited data about its antitumor potential. This study focused on investigating the cytotoxic effects of Hematite (α-Fe 2 O 3 ) from Butea monosperma flower extract on MCF-7 breast cancer cells and its mechanism of action. Green method was created for the synthesis of Hematite (α-Fe 2 O 3 ) using an aqueous extract of B. monosperma flower. Synthesis of hematite (α-Fe 2 O 3 ) was described by different analytical techniques including ultraviolet-visible spectrophotometer, field-emission scanning electron microscopy, X-ray diffraction, and Fourier transforms infrared spectroscopy. Cell viability was determined by the 3-[4, 5-dimethylthiazol-2-yl]-a 2,5-diphenyltetrazolium bromide assay. Reactive oxygen species (ROS) formation was measured using probe 2',7'-dichlorofluorescein diacetate and intracellular calcium (Cai 2+ ) was evaluated with probe flu3-AM. Cells were treated with different concentrations of hematite (α-Fe 2 O 3 ) (1, 3, 6, 10, 15, 25, 50 and 100 μg/mL). The results showed that hematite (α-Fe 2 O 3 ) hindered cell growth in a dose-dependent manner. Hematite (α-Fe 2 O 3 ) appeared to have dose-dependent cytotoxicity against MCF-7 cells through activation of the ROS generation and an increase in the intracellular Cai 2+ (IC 50 52 ± 3.14). In conclusion, the results of this preliminary study demonstrated that hematite (α-Fe 2 O 3 ) from B. monosperma flower extract may be a potential therapeutic potential medicament for human breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Antiproliferative and cytotoxic activity of Hematite (-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

Behera¹,

Pradhan²,

Samantaray³

et al. 2020

Afr. J. Pharm. Pharmacol.

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“…Research in anti-cancer activity of higher plants in India started seriously in the sixties and gained momentum in the seventies. 1 Medicinal herbs constitute indispensable components of the traditional medicines practiced worldwide due to low cost, easy access and ancestral experience. 2 According to the World Health Organization, cancer is a leading cause of death worldwide, and the number of deaths is projected to continuously rise in the coming years.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesized Silver Nanoparticles (AgNPs) from Trapa natans Peel Extract Exhibits Anti-Metastasis and Anti-Biofilm Potentials

Samantaray¹,

Pradhan²,

Behera³

2021

IJPER

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Background: This study deals with the anti-metastasis and anti-biofilm activities using silver nanoparticles (AgNPs) against human breast cancer cells (MCF-7) via in vitro methods. Different studies have been reported that biofilms formed by Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus are resistance to most of the recently used antibiotics due to MDR effect. Materials and methods: The characterization of biosynthesized particles was done by UV-vis spectroscopy, FTIR, SEM and XRD techniques. Cytotoxicity analysis was done by MTT assay and Neutral Red Uptake (NRU) assay. Anti-biofilm activity was carried out by using the bacterial strains of Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus respectively. Results: AgNPs exhibit strong absorption peak in the 420-500 nm range due to Surface Plasmon Resonance in UV-Vis spectroscopy. In FTIR analysis, we found phenol and alcohol compounds (at 3447 cm -1 ), carbonyl groups (at 1631 cm -1 ), alcoholic groups (at 1384 cm -1 ) and polysaccharides (at 1093 cm -1 ). In XRD that AgNPs formed were highly crystalline in nature. In SEM the diameter of AgNPs ranges from 30-90 nm and TEM depicts the size of AgNPs to be 15 ± 2 nm. T. natans-AgNPs exhibits strong cytotoxic activity against MCF-7 breast cancer cell line. Conclusion: The presence of different bioactive molecules in T.natans shows that, green synthesized AgNPs significantly inhibited proliferation of MCF-7 breast cancer cells by inducing apoptosis as well as antibiofilm activity using different bacterial colonies.For the very first time we are reporting the anticancer drugs repositioned as a potential antibiofilm agent in the Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus organisms.

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“…Rats actin expression with a mAb was utilized as an inner control to confirm proportionate aggregate protein stacking. 4,9,23 Immunofluorescence Staining…”

Section: Animalsmentioning

confidence: 99%

Pharmacognostic Evaluation of Curcumin on Diabetic Retinopathy in Alloxan-induced Diabetes through NF-KB and Brn3a Related Mechanism

Pradhan¹,

Dasmohapatra²,

Tripathy³

2018

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Background: Diabetic retinopathy is one of the most common micro vascular complication of diabetes and involves an abnormal pathology of major retinal pigment epithelium, inter retinal oedema and intraocular neovascularisation where pro-inflammatory proteins including ICAM-1,iNOS and VEGF release by activation of enzyme CaMKII/NF-kB expression Diabetic induced oxidative stress followed by deactivation of Brn3a expression in the retinal ganglionic cells are also early events in pathogenesis of Diabetic retinopathy. These factors are important contributors to the development of clinically significant diabetic retinopathy. Objective: Objective of this study to examine the effect of curcumin with antioxidant and anti-inflammatory properties obtained from Curcuma longa against diabetes-induced retinal vascular damage and its mechanism of action by in-vivo in retinas of rat rendered diabetic by alloxan and in vitro in western blotting and RGC tissue culture. Method: We administered curcumin or saline vehicle to experimental animals daily for 12 weeks. Vascular permeability, expression of CaMK II/NF-kB, Retinal morphology and neuropathic change of the retinal ganglion cells were investigated. Results: As an anti-oxidant, curcumin raised Retinal Ganglionic cells by increasing Brn3a expression during oxidative stress condition and subsequently decreased the expression of inflammatory mediators such as VEGF, iNOS and ICAM-1 as an anti-inflammatory agent by inhibiting CaMKII and NF-kB expression. Conclusion: Curcumin, a common food additive has beneficial effects in experimental studies of diseases that are characterised by increased oxidative stress and inflammatory reactions. It appears to be a useful adjunct therapy to possibly inhibit the progression of retinopathy, sight threatening complication faced by diabetic patients.

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A Review on Cuminosides Nanomedicine-: Pharmacognostic approach to Cancer therapeutics

Cited by 4 publications

References 46 publications

Antiproliferative and cytotoxic activity of Hematite (-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

Antiproliferative and cytotoxic activity of Hematite (-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

Biosynthesized Silver Nanoparticles (AgNPs) from Trapa natans Peel Extract Exhibits Anti-Metastasis and Anti-Biofilm Potentials

Pharmacognostic Evaluation of Curcumin on Diabetic Retinopathy in Alloxan-induced Diabetes through NF-KB and Brn3a Related Mechanism

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