Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon

Chuah, Lay Hong; Billa, Nashiru; Roberts, Clive J.; Manickam, Sivakumar

doi:10.3109/10837450.2011.640688

Cited by 106 publications

(63 citation statements)

References 30 publications

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“…Many authors tried Cur with nanoparticles as silver, CS, and liposome nanoparticles in treatment of many types of cancer (Varaprasad et al 2011;Akhtar et al 2012;Mourtas et al 2011). Chuah et al (2011) proved that Cur-coated CS nanoparticles also had potential therapeutic benefits in the treatment of colon cancer through prolonged retention and delivery of Cur. Preparation and drug-releasing property of Cur nanoparticles were firstly prepared by Liu et al (2009).…”

Section: Discussionmentioning

confidence: 98%

Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents

2012

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This study was carried out to evaluate the anti parasitic potential of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents. Non-treated infected control rats were inoculated with Giardia lamblia cysts in a dose of 2 × 10(5) cysts/rat. Experimental group was infected then treated with curcumin, curcumin nanoparticles, chitosan, chitosan nanoparticles, and silver nanoparticles as single or combined therapy. The number of Giardia cysts in stools and trophozoites in intestinal sections were detected. Toxicity of nanoparticles was evaluated by comparing hematological and histopathological parameters of the normal control group and treated non-infected control group. The amount of silver was also measured in the liver, kidney, small intestine, lung, and brain of rats treated with silver nanoparticles. The number of the parasites in stool and small intestinal sections decreased in treated infected rats compared with infected non-treated ones. The effect in the single therapy was better with nanoparticles, and the best effect was detected in nano-silver. The combined therapy gave better results than single. Combination between nanoparticles was better than the combination of nano-forms and native chitosan and curcumin. The best effect was detected in combinations of nano-silver and nano-chitosan but with no full eradication. In conclusion, the highest effect and complete cure was gained by combining the three nano-forms. The parasite was successfully eradicated from stool and intestine. None of the treatments exhibited any toxicity. Accumulated silver in different organs was within the safe limits.

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Section: Discussionmentioning

confidence: 98%

Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents

2012

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“…The most prominent and appropriate of all above is the chemotherapy treatment, which has improved the patients' compliance and their quality of life. 139 Although it is considered a quality treatment approach, yet, conventional chemotherapy results in less concentration of drug to be bioavailable at the site of tumor, making it less effective approach for tumor treatment. In the recent advanced era of nanotechnology, various nanocarriers were successfully used to obtain the desired effects of targeted treatment against colorectal tumor.…”

Section: Colorectal Tumormentioning

confidence: 99%

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Din

Aman

Ullah³

et al. 2017

IJN

1,111

481

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Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. The present review is divided into three main parts: first part presents introduction of various nanocarriers and their relevance in the delivery of anticancer drugs, second part encompasses targeting mechanisms and surface functionalization on nanocarriers and third part covers the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors. This review increases the understanding of tumor treatment with the promising use of nanotechnology.

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“…[33][34][35][36] Some reports on CS-CN-NPs revealed enhanced bioavailability of anticancer and antimalarial drugs in comparison with pure CN but did not show the effect of acidic pH on release of NPs. [37][38][39] In this study, the coating of chitosan nanoparticles with pH sensitive Eudragit polymer was exhaustively studied to overcome the effect of highly acidic environment.…”

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confidence: 99%

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Raj

Kaul

et al. 2018

RSC Adv.

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aIn the present investigation we have prepared and characterized curcumin (CN)-containing chitosan nanoparticles (CS-NPs) coated with Eudragit FS 30D for colon-specific drug delivery for treatment of ulcerative colitis. Methods: CS-NPs were prepared by ionic gelation using tripolyphosphate. To specify pH sensitive delivery, CS-CN-NPs were coated with Eudragit FS 30D by using a solvent evaporation method. Different process parameters were evaluated, and the optimized formulation was characterized by particle size, size distribution, zeta potential and encapsulation efficiency before lyophilization. The lyophilized product was further subjected to Fourier-transform infrared spectroscopy, and particle morphology and in vitro drug release in different media were studied. Results: the kinetics of in vitro drug release from the CS-CN-NPs revealed sustained release behaviour of the developed carriers. In vivo biodistribution study by gamma-scintigraphy showed good accumulation of the developed nanocarriers in the colonic region. Conclusion: sustained and pH stimulated delivery of CN to the colon was successfully attained via coating of CS-NPs with Eudragit FS 30D to circumvent poor absorption and availability of CN.

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Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon

Cited by 106 publications

References 30 publications

Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents

Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

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