Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the dimensional, compositional and interactional dependence

Vecchione, Raffaele; Quagliariello, Vincenzo; Calabria, Dominic; Calcagno, Vincenzo; Luca, Elisa De; Iaffaioli, R. V.; Netti, Paolo A.

doi:10.1016/j.jconrel.2016.05.004

Cited by 117 publications

(81 citation statements)

References 42 publications

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“…The next step is to produce some effective medicines, which may be hampered by problems of mass production. In recent years, our laboratories have been engaged in studying the effects of curcumin in several cancer cell lines [8,9,10,11]. Curcumin is a component of the Indian spice turmeric ( Curcuma longa ), known for its safety and low cost.…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

et al. 2017

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Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for the treatment of numerous diseases, including cancer, in Oriental countries. The aim of this study is to investigate the anti-inflammatory, anticancer and anti-metastatic activities of Ganoderma lucidum extracts in melanoma and triple-negative breast cancer cells. Ganoderma lucidum extracts were prepared by using common organic solvents; MDA-MB 231 and B16-F10 cell lines were adopted as cellular models for triple-negative breast cancer and melanoma and characterized for cell viability, wound-healing assay and measurement of cytokines secreted by cancer cells under pro-inflammatory conditions (incubation with lipopolysaccharide, LPS) and pretreatment with Ganoderma lucidum extract at different concentrations. Our study demonstrates, for the first time, how Ganoderma lucidum extracts can significantly inhibit the release of IL-8, IL-6, MMP-2 and MMP-9 in cancer cells under pro-inflammatory condition. Interestingly, Ganoderma lucidum extracts significantly also decrease the viability of both cancer cells in a time- and concentration-dependent manner, with abilities to reduce cell migration over time, which is correlated with a lower release of matrix metalloproteases. Taken together, these results indicate the possible use of Ganoderma lucidum extract for the therapeutic management of melanoma and human triple-negative breast cancer.

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Section: Introductionmentioning

confidence: 99%

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

et al. 2017

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“…In detail, the inner oil‐core was loaded with FITC (Figure S3, Supporting Information, left). As described in previous works, the liquid template can encapsulate dyes (e.g., nile red and fluorescein) or contrast agents (e.g., iron oxide NPs and CdSe QDs), thus suggesting a possible multi‐imaging of the final nanocarrier. On the other side, the outer shell was conjugated with Rhodamine B (Figure S3, Supporting Information, right) by simply adding a methacrylate derivative of the dye during the shell growth.…”

Section: Resultsmentioning

confidence: 98%

“…Confocal and STED Microscopy : For confocal laser scanning microscope studies, we followed the same procedure followed by our research work MCF‐7 cells were cultured in Dulbecco's modified Eagle's medium (Gibco) containing 10% v/v FBS, 1% v/v Pen‐Strep at 37 °C in a humidified 5% CO 2 atmosphere. After, 5 × 10 3 cells per well were seeded in a 24‐well plate and allowed to grow for 24 h. For imaging studies, the medium was then replaced with fluorescent PEG‐NE (at 0.05% of oil) suspension in culture medium and incubated for 0.5, 4, 8, and 24 h. After incubation time, cancer cells were thoroughly rinsed three times with PBS and fixed with a 2.5% glutaraldehyde in PBS for 20 min.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we proposed the use of nanoemulsions as a vehicle for magnetic cobalt‐ferrite NPs as imaging contrast agents . The nanoemulsions developed by us possess some pharmaceutical and clinical advantages, such as easy of manufacture, scalable production, good biocompatibility, biodegradability, reasonable stability, and the possibility to incorporate hydrophobic drugs and inorganic NPs …”

Section: Introductionmentioning

confidence: 99%

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Oil Core–PEG Shell Nanocarriers for In Vivo MRI Imaging

Calcagno

Vecchione

Quagliariello

et al. 2019

Adv Healthcare Materials

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Oil‐in‐water emulsions represent a promising carrier for in vivo imaging because of the possibility to convey poorly water‐soluble species. To promote accumulation at the tumor site and prolong circulation time, reduction of carrier size and surface PEGylation plays a fundamental role. In this work a novel, simple method to design an oil‐core/PEG‐shell nanocarrier is reported. A PEG‐shell is grown around a monodisperse oil‐in‐water nanoemulsion with a one‐pot method, using the radical polymerization of poly(ethylene glycol)diacrylate. PEG polymerization is triggered by UV, obtaining a PEG‐shell with tunable thickness. This core–shell nanosystem combines the eluding feature of the PEG with the ability to confine high payloads of lipophilic species. Indeed, the core is successfully loaded with a lipophilic contrast agent, namely super paramagnetic iron oxide nanocubes. Interestingly, it is demonstrated an in vitro and an in vivo MRI response of the nanocapsules. Additionally, when the nanosystem loaded with nanocubes is mixed with a fluorescent contrast agent, indo‐cyanine green, a relevant in vitro photoacoustic effect is observed. Moreover, viability and cellular uptake studies show no significant cell cytotoxicity. These results, together with the choice of low cost materials and the scale up production, make this nanocarrier a potential platform for in vivo imaging.

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“…Recently, a curcumin-loaded food grade nanoemulsion for oral delivery developed with a particle size of 110 nm showed a higher bioavailability at lower dosage levels. 153 In another study, curcumin-loaded PLGA NP was prepared for oral delivery with a particle size of ~158 nm, and it showed enhanced solubility and bioavailability. The oral bioavailability of nano-formulated curcumin showed a 22 times increase over conventional curcumin.…”

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confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the dimensional, compositional and interactional dependence

Cited by 117 publications

References 42 publications

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

Oil Core–PEG Shell Nanocarriers for In Vivo MRI Imaging

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

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Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the dimensional, compositional and interactional dependence

Cited by 117 publications

References 42 publications

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

Oil Core–PEG Shell Nanocarriers for In Vivo MRI Imaging

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

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Product

Resources

About

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status