Curcumin attenuates copper-induced oxidative stress and neurotoxicity in Drosophila melanogaster

Oxidative stress and apoptotic effects of copper and cadmium in the zebrafish liver cell line ZFL

“…NAC is a fast-acting antioxidant by triggering intracellular hydrogen sulfide production [ 66 ]. Besides NAC, Curcumin was reported to reduce copper-induced oxidative stress in Drosophila melanogaster [ 67 ]. The protective effect of NAC was shown to be better than Curcumin [ 68 ].…”

Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced locomotor and reproductive senescence and altered biochemical parameters of oxidative damage in Canton-S Drosophila melanogaster

“…Flies exposed to 10–200 μM of B[a]P and 1–10 μM of BPDE for 4 days were prepared and used for biochemical assays following the protocols previously described by Abolaji et al [ 21 ]. According to these protocols, the method of Lowry et al [ 22 ] was adopted for the determination of protein concentration.…”

“…H 2 O 2 values estimated using a standard curve were expressed in μmole/mg protein. The Griess reaction assay [ 21 ] was used for the determination of Nitric oxide level. 250 μL of sample was incubated in 250 μL of Griess reagent for 20 min at room temperature.…”

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review

“…CUR restored the cellular antioxidant status, including total thiol, CAT, glutathione Stransferase activities, and reduced the accumulation of NO level in the DM. 162 Treatment with CUR (10 mg/kg, for 7 weeks) in the Alzheimer's disease (AD) model decreased the amount of protein carbonylation and glutathione in the liver, as well as MDA in the serum, but increased GSH activity in the blood and improved the abilities of active avoidance and locomotor activity, as well as attenuated neurodegeneration. 163 Treatment with CUR (100 and 200 mg/kg, for 4 weeks) on Pb-induced neurotoxicity in rat, improved the motor score, reduced the concentration of Pb in the cerebellum, reduced MDA levels, increased SOD activity, and restored the histological architecture of the cerebellum.…”