Curcumin as an Add-on Therapy of Moderate Partially Controlled Asthma

Estimating Pulmonary Function, Interleukin-6 (IL-6), And Superoxide Dismutase-3 (EC-SOD3) Levels in Patients with Chronic Bronchial Asthma on Curcumin Adjuvant Therapy

“…Meanwhile, the value of ACT in the present study was highly improved after the curcumin supplement regimen only (increased by 41% vs 17.1%, p<0.001). In another study done by Jusufovic et al (2017), curcumin at the dose of 500 mg twice daily in combination with medium-dose inhaled corticosteroid was assessed in 50 non-smoker patients with moderate partially controlled asthma for two months and compared to a parallel number of patients receiving only medium-dose inhaled corticosteroid. There was a highly significant increase in the percentage of predicted FEV1 in the curcumin group (increased by 7% vs 2%) and ACT scores (19 % vs 13%) (p<0.0001) (Jusufovic, et al, 2017).…”

“…Those two studies considered FEV1 as the best indication of lung function (Jusufovic, et al, 2017;Self, 2013. ).…”

“…5mg only of piperine was found in the combination with curcumin to enhance its bioavailability while the anti-inflammatory effect of piperine required higher doses ranging from 20-100mg/kg (Bang, et al, 2009). Up to the best search, no data was available to compare the effect of curcumin on serum level of IL6 within asthmatic patients, except that studies that explored the antiinflammatory effect of curcumin supplement in asthma measured other parameters such as Creactive protein (CRP) level and erythrocyte sedimentation rate (ESR) (Abidi, et al, 2014;Jusufovic, et al, 2017). On experiment level, curcumin was found to diminish airways remodeling in asthma when administered intraperitoneally (Karaman, et al, 2012).…”

“…The presence of piperine contributes to a 154% increase in the systemic bioavailability of curcumin in rats while in human 20 mg piperine produced a 2000% increase in the systemic bioavailability of curcumin (Aggarwal et al, 2007) due to inhibition of hepatic and intestinal glucuronidation of curcumin by piperine (Fadus et al, 2016). Curcumin doses used in the previous studies ranged from 500-1000 mg twice daily (Abidi et al, 2014, Jusufovic et al, 2017, Kim et al, 2011.…”

Adjunctive nano‐curcumin therapy improves inflammatory and clinical indices in children with cystic fibrosis: A randomized clinical trial

“…In a study by Jusufovic et al (2017), which evaluated the effect of curcumin plus inhaled corticosteroids in adults with known F I G U R E 3 Evaluation of clinical outcome between two groups before and after the intervention. Adjusted mean changes of FEV1 percent in the curcumin and placebo groups did not show any significant changes (a), adjusted mean changes of forced vital capacity percent in the curcumin and placebo groups did not show any significant changes (b), adjusted mean changes of body mass index (BMI) z-score in curcumin and placebo groups showed that BMI z-score improved significantly in the curcumin group from baseline by independent t-test, but intra-group changes comparison was not significant (c).…”