Curcumin as a great contributor for the treatment and mitigation of colorectal cancer

Karthika, Chenmala; Balaji, Hari; Mano, Vignesh; Radhakrishnan, Arun; Janani, S.; Akter, Rokeya; Kaushik, Deepak; Rahman, Md. Habibur

doi:10.1016/j.exger.2021.111438

Cited by 33 publications

(17 citation statements)

References 78 publications

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“…The natural compound curcumin has previously shown multiple anti-cancer effects against several different cancer cell types, such as breast cancer, lung cancer or pancreatic cancer [35][36][37]. Recently, it was demonstrated that curcumin enhances the pro-apoptotic effect of TRAIL thus leading to induction of apoptosis through an upregulation of DR4 and DR5, two TRAIL receptors [24].…”

Section: Discussionmentioning

confidence: 99%

Effects of Curcumin Analogues DMC and EF24 in Combination with the Cytokine TRAIL against Kidney Cancer

et al. 2021

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The natural compound curcumin has been shown to have therapeutic potential against a wide range of diseases such as cancer. Curcumin reduces cell viability of renal cell carcinoma (RCC) cells when combined with TNF-related apoptosis-inducing ligand (TRAIL), a cytokine that specifically targets cancer cells, by helping overcome TRAIL resistance. However, the therapeutic effects of curcumin are limited by its low bioavailability. Similar compounds to curcumin with higher bioavailability, such as demethoxycurcumin (DMC) and 3,5-bis(2-fluorobenzylidene)-4-piperidone (EF24), can potentially have similar anticancer effects and show a similar synergy with TRAIL, thus reducing RCC viability. This study aims to show the effects of DMC and EF24 in combination with TRAIL at reducing ACHN cell viability and ACHN cell migration. It also shows the changes in death receptor 4 (DR4) expression after treatment with these compounds individually and in combination with TRAIL, which can play a role in their mechanism of action.

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Section: Discussionmentioning

confidence: 99%

Effects of Curcumin Analogues DMC and EF24 in Combination with the Cytokine TRAIL against Kidney Cancer

et al. 2021

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“…A micelle is a spherical vesicle made up of amphiphilic surfactant molecules that spontaneously assemble in water. Micelles are commonly utilized to deliver drugs that are not very water soluble, such as curcumin [ 133 ]. Curcumin can be added pre- or post-micelle production to solubilize it within the hydrophobic center of micelles.…”

Section: Various Nano Drug Delivery Systems For Curcuminmentioning

confidence: 99%

The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Tagde

Tagde²,

Islam

et al. 2021

Molecules

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Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.

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“…Curcumin(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5dione), also known as diferuloylmethane, is a natural compound found in the rhizome of Curcuma longa (turmeric) and some plants in the Araceae family. A number of studies have shown that curcumin has anti-cancer properties in vivo and in vitro [71][72][73][74]. These studies indicate that curcumin can inhibit cell proliferation and induce cell cycle arrest and apoptosis through a variety of mechanisms [72][73][74].…”

Section: Cnds Based Nano Systems For Drug Delivery and Its Use In Cancer Theragnosticmentioning

confidence: 99%

“…A number of studies have shown that curcumin has anti-cancer properties in vivo and in vitro [71][72][73][74]. These studies indicate that curcumin can inhibit cell proliferation and induce cell cycle arrest and apoptosis through a variety of mechanisms [72][73][74]. However, a major challenge in using curcumin to treat cancer is its bioavailability [71].…”

Section: Cnds Based Nano Systems For Drug Delivery and Its Use In Cancer Theragnosticmentioning

confidence: 99%

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

Khan

Dunphy

Anike

et al. 2021

IJMS

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Carbon nanodots (CNDs) are an emerging class of nanomaterials and have generated much interest in the field of biomedicine by way of unique properties, such as superior biocompatibility, stability, excellent photoluminescence, simple green synthesis, and easy surface modification. CNDs have been featured in a host of applications, including bioimaging, biosensing, and therapy. In this review, we summarize the latest research progress of CNDs and discuss key advances in our comprehension of CNDs and their potential as biomedical tools. We highlighted the recent developments in the understanding of the functional tailoring of CNDs by modifying dopants and surface molecules, which have yielded a deeper understanding of their antioxidant behavior and mechanisms of action. The increasing amount of in vitro research regarding CNDs has also spawned interest in in vivo practices. Chief among them, we discuss the emergence of research analyzing CNDs as useful therapeutic agents in various disease states. Each subject is debated with reflection on future studies that may further our grasp of CNDs.

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Curcumin as a great contributor for the treatment and mitigation of colorectal cancer

Cited by 33 publications

References 78 publications

Effects of Curcumin Analogues DMC and EF24 in Combination with the Cytokine TRAIL against Kidney Cancer

Effects of Curcumin Analogues DMC and EF24 in Combination with the Cytokine TRAIL against Kidney Cancer

The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Recent Advances in Carbon Nanodots: A Promising Nanomaterial for Biomedical Applications

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