Curcumin and whey protein binding and structural characteristics of their complex evidenced by atomic force microscopy

Racz, Levente Zsolt; PALTINEAN, Gertrud-Alexandra; Petean, Ioan; Tomoaia, Gheorghe; Pop, Lucian Cristian; Arghir, George; Levei, Erika Andrea; Mocanu, Aurora; Rácz, Csaba-Pal; Tomoaia-Cotişel, Maria

doi:10.24193/subbchem.2022.3.05

Cited by 6 publications

(4 citation statements)

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“…The CCM bioavailability, solubility, and stability, as well as its antioxidant activity were significantly improved by its nano complexation with whey protein concentrate [ 234 , 235 ]. In consequence, the effective role of whey protein concentrate in the cellular penetration and internalization of the CCM-WPC complex and in the specific intracellular trafficking of curcumin including mitochondria or nucleus becomes progressively important as we focus to further enhance the effectiveness of curcumin therapeutic effect.…”

Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.

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Section: Curcumin Bioavailability Improvingmentioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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“…Also, it is known to induce apoptosis in prostate cancer cells but also to prevent the progression of this cancer [3]. This proactive compound can form innovative composites and complexes with applications in medicine and in this sense facilitates the understanding of the mechanisms of action during application [4][5][6][7][8][9].…”

Section: Fig 1 Bioactive Compounds From Plantsmentioning

confidence: 99%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

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This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

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“…In addition, a further functionalization of these ceramic coating with more natural substances that would not hold any side effects, such as carotenoids [104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122], would also be beneficial. Some carotenoids have been proven to exhibit antibacterial properties [123][124][125][126][127][128].…”

Section: Future Trendsmentioning

confidence: 99%

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2022

AnnalsARSciPhysChem

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Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAP) is widely used in regards to orthopedic applications due to its similarity to the mineral component in bone. However, while HAP aids with osseointegration it does nothing when it comes to orthopedic infections. Moreover, the prevalence of antibiotic resistance makes treatment even more difficult. In view of this, adding silver to hydroxyapatite has been a focus of many studies due to the combined bioactivity of HAP and excellent antibacterial properties of Ag. The present work brings a brief introduction to more recent studies regarding the HAP-silver combination and its effect on different pathogenic strains. The effect of silver on benign cells is also discussed based on in vitro cultures and in vivo studies.

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Curcumin and whey protein binding and structural characteristics of their complex evidenced by atomic force microscopy

Cited by 6 publications

References 0 publications

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

Interaction of Bioactive Compounds With Ceramic Materials – A Review

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