Curcumin and Turmeric Delay Streptozotocin-Induced Diabetic Cataract in Rats

Suryanarayana, Palla; Saraswat, Megha; Mrudula, T.; Krishna, T. Prasanna; Krishnaswamy, Kamala; Reddy, G. Bhanuprakash

doi:10.1167/iovs.04-1304

Cited by 291 publications

(266 citation statements)

References 35 publications

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“…The onset and progression of the cataract during experiment was monitored using a slit lamp biomicroscope (Kowa Portable, Japan) as described by us previously (21). Initiation, progression, and maturation of lenticular opacity were graded as described previously.…”

Section: Slit Lamp Examination and Cataract Classificationmentioning

confidence: 99%

Increased risk of cataract development in WNIN‐obese rats due to accumulation of intralenticular sorbitol

et al. 2013

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Epidemiological studies have reported an association between obesity and increased incidence of ocular complications including cataract, yet the underlying biochemical and molecular mechanisms remained unclear. Previously we had demonstrated accumulation of sorbitol in the lens of obese rats (WNIN/Ob) and more so in a related strain with impaired glucose tolerance (WNIN/GR-Ob). However, only a few (15-20%) WNIN/Ob and WNIN/GR-Ob rats develop cataracts spontaneously with age. To gain further insights, we investigated the susceptibility of eye lens proteins of these obese rat strains to heat-and UV-induced aggregation in vitro, lens opacification upon glucose-mediated sorbitol accumulation ex vivo, and onset and progression of cataract was followed by galactose feeding and streptozotocin (STZ) injection. The results indicated increased susceptibility toward heat-or UV-induced aggregation of lens proteins in obese animals compared to their littermate lean controls. Further, in organ culture studies glucose-induced sorbitol accumulation was found to be higher and thus the lens opacification was faster in obese animals compared to their lean littermates. Also, the onset and progression of galactose-or STZ-induced cataractogenesis was faster in obese animals compared to lean control. These results together with our previous observations suggest that obesity status could lead to hyperaccumulation of sorbitol in eye lens, predisposing them to cataract, primarily by increasing their susceptibility to environmental and/or physiological factors. Further, intralenticular sorbitol accumulation beyond a threshold level could lead to cataract in WNIN/Ob and WNIN/ GR-Ob rats. V C 2013 IUBMB Life, 65(5): [472][473][474][475][476][477][478] 2013

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Section: Slit Lamp Examination and Cataract Classificationmentioning

confidence: 99%

Increased risk of cataract development in WNIN‐obese rats due to accumulation of intralenticular sorbitol

et al. 2013

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“…Identification & Authentication of the rhizomes of curcuma longa and amla was done in Ayurvedic college of Bharati Vidyapeeth. Preparation was done as per the ayurvedic literature and standards compared with Ayurvedic pharmacopoeia of India [19]. All the animals were treated with the test drug and standard drug according to groups.…”

Section: Discussionmentioning

confidence: 99%

Preventive and Protective Effect of Nishamalaki in STZ Induced Diabetic Complications in Wistar Rats

Dawane

Pandit

Deshpande

et al. 2016

JCDR

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“…The fruit extract has many pharmacological activities for the treatment of a number of diseases and is a constituent of many hepatoprotective formulations [9]. Several recent reports revealed that fruit extract of Emblica officinalis protect against radiation [10], antiatherosclerosis [11], possess antidiabetic activity [12,13], inhibits aging process [14], gastroprotective [15], cytoprotective and immunomodulatory [16]. Despite its extensive medicinal use no information is available related to its use on alcoholinduced hepatotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Emblica officinalis Against Alcohol-Induced Hepatic Injury by Ameliorating Oxidative Stress in Rats

et al. 2010

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The effect of Emblica officinalis fruit extract (EFE) against alcohol-induced hepatic damage in rats was investigated in the present study. In vitro studies showed that EFE possesses antioxidant as well nitric oxide (NO) scavenging activity. In vivo administration of alcohol (5 g/kg b.wt/day) for 60 days resulted increased liver lipid peroxidation, protein carbonyls, nitrite plus nitrate levels. Alcohol administration also significantly lowers the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and reduced glutathione as compared with control rats. Administration of EFE (250 mg/kg body weight) to alcoholic rats significantly brought the plasma enzymes towards near normal level and also significantly reduced the levels of lipid peroxidation, protein carbonyls and restored the enzymic and nonenzymatic antioxidants level. This observation was supplemented by histopathological examination in liver. Our data indicate that the tannoid, flavonoid and NO scavenging compounds present in EFE may offer protection against free radical mediated oxidative stress in rat hepatocytes of animals with alcohol-induced liver injury.

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Curcumin and Turmeric Delay Streptozotocin-Induced Diabetic Cataract in Rats

Cited by 291 publications

References 35 publications

Increased risk of cataract development in WNIN‐obese rats due to accumulation of intralenticular sorbitol

Increased risk of cataract development in WNIN‐obese rats due to accumulation of intralenticular sorbitol

Preventive and Protective Effect of Nishamalaki in STZ Induced Diabetic Complications in Wistar Rats

Protective Effect of Emblica officinalis Against Alcohol-Induced Hepatic Injury by Ameliorating Oxidative Stress in Rats

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