Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers

Ostheller, Maike-Elisa; Abdelgawad, Abdelrahman M.; Balakrishnan, Naveen Kumar; Hassanin, Ahmed H.; Groten, Robert; Seide, Gunnar Henrik

doi:10.3390/nano12020283

Cited by 12 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before thermal treatment, alizarin showed antibacterial activity at the lowest tested concentration of 2 mg/mL. Curcumin was active at concentrations exceeding 5 mg/mL, and quercetin was active at concentrations exceeding 2 mg/mL, in agreement with earlier reports [ 24 ]. However, the activity of alizarin and curcumin was diminished by heat treatment, and post-treatment concentrations of more than 15 mg/mL were required to exert an antibacterial effect.…”

Section: Resultssupporting

confidence: 91%

“…For the assessment of the antibacterial potential of the C5 fiber web, these fungal colonies were neglected. This reduction in the antibacterial activity is likely to reflect the distribution of the dye in the polymer, with only those molecules presented on the fiber surface being able to kill the bacteria [ 24 ]. Similarly, quercetin-loaded PLA fibers were previously shown to lack the leaching of quercetin while retaining antibacterial activity [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…For example, the dye alizarin is used extensively in solar cells and is also researched for other electronic applications [ 20 ]. The antibacterial activity of alizarin [ 21 ], quercetin [ 22 ], and curcumin [ 23 , 24 ] makes them suitable for applications such as food packaging [ 25 ] and wound dressings [ 26 ]. However, to the best of our knowledge, these additives have been used mainly in solution processing methods or as coatings, with only limited investigation of melt electrospinning.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pilot-Scale Electrospinning of PLA Using Biobased Dyes as Multifunctional Additives

et al. 2022

Self Cite

View full text Add to dashboard Cite

Fibers with diameters in the lower micrometer range have unique properties suitable for applications in the textile and biomedical industries. Such fibers are usually produced by solution electrospinning, but this process is environmentally harmful because it requires the use of toxic solvents. Melt electrospinning is a sustainable alternative but the high viscosity and low electrical conductivity of molten polymers produce thicker fibers. Here, we used multifunctional biobased dyes as additives to improve the spinnability of polylactic acid (PLA), improving the spinnability by reducing the electrical resistance of the melt, and incorporating antibacterial activity against Staphylococcus aureus. Spinning trials using our 600-nozzle pilot-scale melt-electrospinning device showed that the addition of dyes produced narrower fibers in the resulting fiber web, with a minimum diameter of ~9 µm for the fiber containing 3% (w/w) of curcumin. The reduction in diameter was low at lower throughputs but more significant at higher throughputs, where the diameter reduced from 46 µm to approximately 23 µm. Although all three dyes showed antibacterial activity, only the PLA melt containing 5% (w/w) curcumin retained this property in the fiber web. Our results provide the basis for the development of environmentally friendly melt-electrospinning processes for the pilot-scale manufacturing of microfibers.

show abstract

Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pilot-Scale Electrospinning of PLA Using Biobased Dyes as Multifunctional Additives

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Melt electrospinning is a more efficient process and the absence of solvents makes it more environmentally sustainable, but the minimum fiber diameter achieved at the laboratory scale is in the low micrometer range [ 10 , 11 ]. Several challenges must be overcome to achieve the larger-scale production of nanofibers [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…One of these challenges is the high viscosity and low electrical conductivity of polymer melts [ 13 , 15 , 16 , 17 ], which can be addressed in part by the inclusion of additives [ 18 ]. For example, in our previous study, we investigated the use of curcumin and silver nanoparticles as multifunctional additives to reduce the viscosity of molten polybutylene succinate (PBS) while increasing its electrical conductivity [ 11 ]. This reduced the fiber diameter compared to pure PBS but did not come close to the nanoscale fiber diameters typically achieved by solution-electrospinning.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Electrical Polarity on the Diameter of Biobased Polybutylene Succinate Fibers during Melt Electrospinning

et al. 2022

Self Cite

View full text Add to dashboard Cite

Melt electrospinning is a simple, versatile, and widely used technique for the production of microfibers and sub-microfibers. Polybutylene succinate (PBS) is a promising raw material for the preparation of melt-electrospun fibers at the laboratory scale. The inclusion of additives in the PBS melt can reduce the final fiber diameter, but economically feasible larger-scale processes remain challenging. The fiber diameter can also be reduced by machine optimization, although this is expensive due to the complexity of melt-electrospinning devices. Changes in electrical field polarity have provided a low-cost strategy to reduce the diameter of fibers produced by solution-electrospinning, but there is little information about the effect of this parameter on the final diameter of melt-electrospun fibers. We therefore determined the effect of field polarity on the diameter of melt-electrospun PBS fibers at the laboratory scale and investigated the transferability of these results to our 600-nozzle pilot-scale device. Changing the polarity achieved a significant reduction in fiber diameter of ~50% at the laboratory scale and ~30% at the pilot scale, resulting in a minimum average fiber diameter of 10.88 µm. Although the effect of field polarity on fiber diameter was similar at both scales, the fibers in the web stuck together at the laboratory scale but not at the pilot scale. We have developed an inexpensive method to reduce the diameter of melt-electrospun PBS fibers and our data provide insight into the transferability of melt electrospinning from the laboratory to a pilot-scale machine.

show abstract

Production and comprehensive characterization of PVA/chitosan transdermal composite mats loaded with bioactive curcumin; evaluation of its release kinetics, antioxidant, antimicrobial, and biocompatibility features

Ciftci,

Özarslan,

Evcimen Duygulu

2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Recently, researchers have shown increasing interest in incorporating bioactive substances with therapeutic properties into fiber‐structured mat biomaterials, which are favored as tissue scaffolds for wound healing applications. In this study, curcumin (Cur)‐loaded polyvinyl alcohol (PVA)/chitosan (CS) composite mats were produced using the electrospinning method and followed by the freeze‐drying method. Scanning electron microscope images proved the homogeneous structure of the composite mats, and Fourier transform infrared spectroscopy analysis showed that the Cur‐loaded composite mats were successfully produced. The antibacterial activity of Cur‐loaded PVA/CS composite mats was evaluated against Escherichia coli and Staphylococcus aureus, and the results showed that the antibacterial activity of the composite mats increased with the addition of Cur. Furthermore, the antioxidant test, release kinetics tests, and in vitro biocompatibility studies such as cytotoxicity, staining, and scratch assay of Cur‐loaded PVA/CS composite mats were carried out. The results showed that adding Cur enhanced the bioactivity of PVA10/CS10 composite mats. Further, the biocompatibility findings indicated that 10Cur‐PVA10/CS10 exhibited the highest viability value throughout all incubation periods compared with the other samples. Moreover, the highest rate of scratch closure on the 10Cur‐PVA/10/CS10 composite mats was observed at the end of 24 h compared with the other composite mats. These findings indicate that the Cur‐loaded PVA10/CS10 composite mats significantly positively impact cell migration and wound healing, making them a promising candidate as transdermal composite mats for tissue engineering and wound care applications.

show abstract

Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers

Cited by 12 publications

References 37 publications

Pilot-Scale Electrospinning of PLA Using Biobased Dyes as Multifunctional Additives

Pilot-Scale Electrospinning of PLA Using Biobased Dyes as Multifunctional Additives

The Effect of Electrical Polarity on the Diameter of Biobased Polybutylene Succinate Fibers during Melt Electrospinning

Production and comprehensive characterization of PVA/chitosan transdermal composite mats loaded with bioactive curcumin; evaluation of its release kinetics, antioxidant, antimicrobial, and biocompatibility features

Contact Info

Product

Resources

About