Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice

Y, Liu; Ym, Wu; Yu, Yang; Cs, Cao; Zhang, Junyi; K, Li; Py, Zhang

doi:10.1177/0960327114551396

Cited by 33 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…B(a)P induces oxidative stress, which plays an important role in inducing lung toxicity and lung cancer . LPO is a well‐known oxidative stress marker and several studies showed that significant increase in the formation of malondialdehyde (MDA), a lipid peroxidation product was observed after B(a)P treatment . It has previously shown that MDA acts as a mutagen and tumor promoter .…”

Section: Discussionmentioning

confidence: 99%

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

Shahid

Rashid

Ali

et al. 2016

Environmental Toxicology

View full text Add to dashboard Cite

Benzo(a)pyrene [B(a)P] is a well-known carcinogen present in the environment. In this study, we evaluated the protective potential of methanolic bark extract of Acacia catechu Willd. (MEBA) against the lung toxicity induced by B(a)P in Swiss albino mice. To determine the protective efficacy of MEBA, it was orally administered to the mice at two doses (200 and 400 mg/kg body weight) once daily for 7 days. Mice were also exposed (orally) to B(a)P at a dose of 125 mg/kg body weight on 7th day. Administration of B(a)P increased the activities of toxicity markers such as LDH, LPO, and XO with a subsequent decrease in the activities of tissue anti-oxidant armory (CAT, SOD, GST, GPx, GR, QR, and GSH). It also caused activation of the apoptotic and inflammatory pathway by upregulation of TNF-α, NF-kB, COX-2, p53, bax, caspase-3, and downregulating Bcl-2. Pretreatment with MEBA at two different doses (200 and 400 mg/kg body weight) significantly ameliorates B(a)P-induced increased toxicity markers and activities of detoxifying enzymes along with the levels of glutathione content. It also significantly attenuated expression of apoptotic and inflammatory markers in the lungs. Histological results further confirmed the protective role of MEBA against B(a)P-induced lung toxicity. The results indicate that MEBA may be beneficial in ameliorating the B(a)P-induced oxidative stress, inflammation, and apoptosis in the lungs of mice. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1566-1577, 2017.

show abstract

Section: Discussionmentioning

confidence: 99%

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

Shahid

Rashid

Ali

et al. 2016

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…Though there are enough evidences chronicled in literature on the in vitro efficacy of curcumin in killing lung cancer cells, it has only been recently that the detailed molecular evidence‐based information regarding the in vivo efficacy of dietary curcumin in preventing lung cancer incidence and progression is reporting . This study also is an attempt to contribute to this knowledge pool.…”

Section: Discussionmentioning

confidence: 99%

“…6K and 6L), a molecular event reported to be regulated by NF-jB and MAPK signaling [31,34]. has only been recently that the detailed molecular evidencebased information regarding the in vivo efficacy of dietary curcumin in preventing lung cancer incidence and progression is reporting [35][36][37]. This study also is an attempt to contribute to this knowledge pool.…”

Section: Curcumin Downregulates B[a]p-induced Nf-jb Activity Mapk Simentioning

confidence: 99%

Curcumin inhibits B[a]PDE‐induced procarcinogenic signals in lung cancer cells, and curbs B[a]P‐induced mutagenesis and lung carcinogenesis

et al. 2015

View full text Add to dashboard Cite

Benzo[a]pyrene is a procarcinogen present in environment and cigarette smoke, which could be bio-transformed in vivo to B[a]PDE, a potent carcinogen known to form DNA adducts and induce mutations. We observed that curcumin, a known chemopreventive, could significantly inhibit the survival of lung cancer cells exposed to B[a]PDE. It also downregulates B[a]PDE-induced nuclear translocation of NF-κB as assessed by Electrophoretic Mobility Shift Assay (EMSA) and NF-κB-dependent reporter gene assay. Ames assay demonstrated its ability to revert the mutagenic property of benzo[a]pyrene. These observations prompted us to evaluate the efficacy of curcumin in preventing B[a]P-induced lung carcinogenesis in vivo and to explore the molecular mechanism associated with it. The average number of tumor nodules present in the lungs of the Swiss albino mice, which received benzo[a]pyrene, was significantly high compared to that received curcumin as 2% diet along with B[a]P. Curcumin treatment significantly reverted histopathological deviations in the lung tissues due to benzo[a]pyrene ingestion. Moreover, curcumin diet reduced benzo[a]pyrene-induced activation of NF-κB and MAPK signaling and Cox-2 transcription in lung tissues of mice. Taken together, this study illustrates multifaceted efficacy of curcumin in preventing lung cancer.

show abstract

“…In contrast to other malignant tumours, especially those of the gastrointestinal tract, the association between diet and the risk of lung cancer is not strong. A slight but statistically significant protective effect of consuming fruit and vegetables has been described, probably owing to their antioxidant and cell growth inhibitory activities 77 . Environmentally, a reduced level of exposure to particulate matter air pollution could contribute to a reduction in the incidence of lung cancer.…”

Section: Preventionmentioning

confidence: 99%

Non-small-cell lung cancer

Gridelli

Rossi

Carbone

et al. 2015

Nat Rev Dis Primers

762

621

View full text Add to dashboard Cite

Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice

Cited by 33 publications

References 31 publications

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice

Curcumin inhibits B[a]PDE‐induced procarcinogenic signals in lung cancer cells, and curbs B[a]P‐induced mutagenesis and lung carcinogenesis

Non-small-cell lung cancer

Contact Info

Product

Resources

About