Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production

Han, Song; Xu, Jing; Guo, Xiangjun; Huang, Mao

doi:10.1111/1440-1681.12848

Cited by 80 publications

(95 citation statements)

References 40 publications

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“…Importantly, curcumin treatment by oral gavage (50 and 150 mg/kg) reduced IAV replication and lung injury in an in vivo animal model [19], clearly illustrating that curcumin can provide a therapeutic benefit to combat infection and virus-induced disease. This latter observation was supported by a study by Han et al [53], who demonstrated that mice infected with the IAV strain PR8 and fed 30 or 100 mg/kg of curcumin had increased survival, reduced bodyweight loss, and lower IAV burden in lung tissues as determined by immunohistochemistry. Bronchoalveolar lavage (BAL) fluid and lung tissues from infected, curcumin-treated mice had lower levels of monocyte chemoattractant protein-1 (MCP-1) and tumour necrosis factor-alpha (TNFα) compared to untreated mice, suggesting reduced inflammation.…”

Section: Influenza a Virusmentioning

confidence: 57%

Curcumin as an Antiviral Agent

Jennings

Parks

2020

Viruses

138

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Section: Influenza a Virusmentioning

confidence: 57%

Curcumin as an Antiviral Agent

Jennings

Parks

2020

Viruses

138

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“…Although a review of AMPK-modulating polyphenols is beyond our scope, we highlight the therapeutic promise of polyphenols against infection. For example, curcumin from Curcuma longa inhibits influenza A viral infection in vitro and in vivo, at least in part by activating AMPK [ 36 ]. The polyphenol epigallocatechin gallate attenuates Tat-induced human immunodeficiency virus (HIV)-1 transactivation by activating AMPK [ 37 ].…”

Section: Multifaceted Role Of Ampk In Antimicrobial Responsesmentioning

confidence: 99%

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal

Kim

Yuk

et al. 2018

IJMS

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5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved in energy metabolism, which is perturbed by infectious stimuli. Indeed, various pathogens modulate AMPK activity, which affects host defenses against infection. In some viral infections, including hepatitis B and C viral infections, AMPK activation is beneficial, but in others such as dengue virus, Ebola virus, and human cytomegaloviral infections, AMPK plays a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response and contribute to the control of microbial and parasitic infections. In addition, this review focuses on the double-edged role of AMPK in innate and adaptive immune responses to infection. Understanding how AMPK regulates host defenses will enable development of more effective host-directed therapeutic strategies against infectious diseases.

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“…It has, therefore, been associated with more than 100 cellular targets, including cytokine s, proteins, transcription factors, and receptors. Previous studies have shown the potential of curcumin as a treatment against Influenza A virus infection, by an effect mediated by modulating immune response to prevent injury to the lung tissue (Han, Xu, Guo & Huang 2018). Curcumin has also been shown to have anti neuraminidase (NA) activity for the influenza virus NA protein (Richart et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Virtual Screening of Curcumin and Its Analogs Against the Spike Surface Glycoprotein of SARS-CoV-2 and SARS-CoV

Patel¹,

Rajendran²,

Pakala³

et al. 2020

Preprint

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COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China. The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74 % identity and use similar mechanisms to gain entry into the cell. Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting enzyme 2 (ACE2). Targeting entry of the virus has a better advantage than inhibiting the later stages of the viral life cycle. The crystal structure of the SARS-CoV (6CRV: full length S protein) and SARS-CoV-2 Spike proteins (6M0J: Receptor binding domain, RBD) was used to determine potential small molecule inhibitors. Curcumin, a naturally occurring phytochemical in Curcuma longa, is known to have broad pharmacological properties. In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry. The curcumin and its derivatives displayed binding energies, ΔG, ranging from -10.98 to -5.12 kcal/mol (6CRV) and -10.01 to -5.33 kcal/mol (6M0J). The least binding energy was seen in bis-demethoxycurcumin with: ΔG = -10.98 kcal/mol (6CRV) and -10.01 kcal/mol (6M0J). A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors. However, further research is necessary to investigate the ability of these compounds as viral entry inhibitors.<br>

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Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production

Cited by 80 publications

References 40 publications

Curcumin as an Antiviral Agent

Curcumin as an Antiviral Agent

AMP-Activated Protein Kinase and Host Defense against Infection

Virtual Screening of Curcumin and Its Analogs Against the Spike Surface Glycoprotein of SARS-CoV-2 and SARS-CoV

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