Curcumin alters motor coordination but not total number of Purkinje cells in the cerebellum of adolescent male Wistar rats

Partadiredja, Ginus; Sutarman, Sutarman; Yahya, Taufik Nur; Nuryana, Christiana Tri; Susilowati, Rina

doi:10.3736/jintegrmed2013006

Cited by 11 publications

(10 citation statements)

References 40 publications

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“…is a polyphenolic monomer extract from Turmeric, a Chinese herbal medicine which activates microcirculation and possesses various pharmacological activities including anti-inflammatory, antioxidant, and antiproliferative components. In addition, Curcumin may exert beneficial effects on the motor coordination of adolescent rats exposed to ethanol [76]. Both Curcumin and the Chinese medicine formula with Turmeric may significantly alleviate and improve the symptoms of EM patients [77, 78].…”

Section: Herbal Products Treatment On Endometriosismentioning

confidence: 99%

The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism

Kong

Zhang

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Endometriosis (EM) is one of the common gynecological conditions causing menstrual and pelvic pain and affects 10%–15% of women of reproductive age. In recent years, the complementary and alternative medical (CAM) treatment for EM has become popular due to the few adverse reactions reported. The CAM therapy for EM includes several different treatments such as herbs (herbal prescription, extract, and patent), acupuncture, microwave physiotherapy, and Chinese herb medicine enema (CHM enema). These CAM therapies are effective at relieving dysmenorrhoea, shrinking adnexal masses, and promoting pregnancy, with less unpleasant side effects when compared to hormonal and surgical treatments. In this review, we focus on the status quo of CAM on EM and try to identify therapeutic efficacy and mechanisms based on some clinical and experimental studies. We hope to provide some instructive suggestions for clinical treatment and experimental research in the future.

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Section: Herbal Products Treatment On Endometriosismentioning

confidence: 99%

The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism

Kong

Zhang

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…[11] There are reports supporting the Purkinje cell loss [12] and opposing that. [13] Similarly, reports of cerebellar atrophy without thiamine deficiency are also available. [14,15] Oxidative stress is a crucial component of alcohol-induced neurodegenerations.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Varied Modalities of Tocotrienol Supplementations to Counter the Cerebellar Oxidative Stress Caused by Low-to-moderate Doses of Ethanol in Rats

Dasari¹,

Nayak²

2019

IJCEP

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Background and Aim: Self-intoxication with Ethanol (Et) is a common problem worldwide. Being a psychoactive drug, neurotoxic effects of Et are well known. Cerebellum is highly vulnerable to Et exposure. Tocotrienols (T3) are relatively rare components of vitamin E and have the potential to prevent the oxidative stress and act as neuroprotective. Varied modalities of T3 supplementations were evaluated to identify the possibilities of countering cerebellar oxidative stress caused by low-to-moderate doses of Et exposure. Methods: Four phase of experiments were carried out with nil (Et-0) and three doses of Et exposures (Et-I, Et-II and Et-III) for 4 weeks. In each phase, 4 groups of Wistar rats were maintained with sham supplementation (NT3), Prior Supplementation (PT3), Simultaneous Supplementation (ST3) and Total Supplementation (TT3) with T3 for 6 weeks. Cerebellar levels of reduced Glutathione (GSH), Lipid Peroxidation (LPO) and activities of catalase, Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Glutathione Reductase (GR) were estimated and Superoxide and Peroxide Handling Capacities (SPHCs) were calculated. Results: All the tested cerebellar oxidative stress parameters and handling capacities were significantly influenced by the modalities of T3 supplementation. However, low-to-moderate doses of Et exposures contributed significantly in alterations of LPO level, GPx activity, GR activity and glutathione-dependent SPHC of cerebellum. Conclusion: Critical evaluation of studied parameters suggest insufficient overall performance of ST3 type of supplementation, whereas, TT3 type of supplementation was the best among the modalities of T3 supplementation. However, excess T3 supplementation may not be beneficial in some cases of oxidative stress parameters and SPHC of cerebellum.

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“…The cerebella of the rats were cut according to multistage physical fractionator procedure as was explained in other studies. 18,20,22,23 The entire cerebellum of a given rat was cut parasagitally into slices with a thickness of approximately 2–3 mm. In order to obtain the first sampling fraction ( f 1), a number between 1 and 2 was selected randomly.…”

Section: Methodsmentioning

confidence: 99%

“…The motor coordination of the rats was examined using a rotarod apparatus for rats (Ugo Basile model 7700, Italy). The protocol used for the test was based on the protocol of previous studies [18][19][20] with a slight modification. Briefly, the test began with any given rat was placed on top of the running surface of the rotarod at a stationary position and left to stay there for 1 min in order to familiarize with the apparatus.…”

Section: Motor Coordination Testmentioning

confidence: 99%

High dosage of monosodium glutamate causes deficits of the motor coordination and the number of cerebellar Purkinje cells of rats

2015

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Monosodium glutamate (MSG) has been widely used throughout the world as a flavoring agent of food. However, MSG at certain dosages is also thought to cause damage to many organs, including cerebellum. This study aimed at investigating the effects of different doses of MSG on the motor coordination and the number of Purkinje cells of the cerebellum of Wistar rats. A total of 24 male rats aged 4 to 5 weeks were divided into four groups, namely, control (C), T2.5, T3, and T3.5 groups, which received intraperitoneal injection of 0.9% sodium chloride solution, 2.5 mg/g body weight (bw) of MSG, 3.0 mg/g bw of MSG, and 3.5 mg/g bw of MSG, respectively, for 10 consecutive days. The motor coordination of the rats was examined prior and subsequent to the treatment. The number of cerebellar Purkinje cells was estimated using physical fractionator method. It has been found that the administration of MSG at a dosage of 3.5 mg/g bw, but not at lower dosages, caused a significant decrease of motor coordination and the estimated total number of Purkinje cells of rats. There was also a significant correlation between motor coordination and the total number of Purkinje cells.

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Curcumin alters motor coordination but not total number of Purkinje cells in the cerebellum of adolescent male Wistar rats

Cited by 11 publications

References 40 publications

The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism

The Complementary and Alternative Medicine for Endometriosis: A Review of Utilization and Mechanism

Evaluation of Varied Modalities of Tocotrienol Supplementations to Counter the Cerebellar Oxidative Stress Caused by Low-to-moderate Doses of Ethanol in Rats

High dosage of monosodium glutamate causes deficits of the motor coordination and the number of cerebellar Purkinje cells of rats

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