Curcumin Acetate Nanocrystals for Sustained Pulmonary Delivery: Preparation, Characterization and In Vivo Evaluation

Hu, Xiao; Yang, Feifei; Wei, Xiao-Lan; Yao, Guangyin; Liu, Chunyi; Zheng, Ying

doi:10.1166/jbn.2017.2326

Cited by 30 publications

(15 citation statements)

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“…In addition, the huge surface area of the alveoli (more than 100 m 2 ) and the extremely short distance from the gas side to the blood side in alveoli (0.1–0.2 μm) also make big contribution to the rapid drug absorption in the lung 14 . The thinness of the alveolar region offers great potential for the rapid systemic absorption of drug molecules within seconds or minutes 11 . Moreover, there are abundant capillaries around the alveoli 14 .…”

Section: Factors Influencing the Pulmonary Exposure Of The Inhaled Medicinesmentioning

confidence: 99%

“…One of the strategies to extend the pulmonary drug exposure may be exploiting sustained release formulations for pulmonary administration 41 . These sustained release formulations could confer an extended time of the drug action, reduce the frequency of dosing and consequently improve the patient compliance and even reduce their side effects 11 , 43 . Besides the inhaled sustained release formulations, there are also some other physical and chemical approaches including particle engineering and chemical synthesis and modification that have been exploited to extend the pulmonary exposure of the inhaled medicines to bring clinical benefits to the patients recently.…”

Section: Strategies To Extend the Pulmonary Exposure Of The Inhaled Medicinesmentioning

confidence: 99%

“…Consequently, the local drug concentration in the lungs could decline rapidly to fail to exert optimal therapeutic effects. In order to maintain the effective drug concentration at the action sites, patients have to take the drugs frequently, which may result in poor patient compliance and adherence 11 , 12 . Extending the retention of inhaled particles in the lungs is an effective strategy to achieve prolonged pharmacological effect.…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Guo

Bera

Shi

et al. 2021

Acta Pharmaceutica Sinica B

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Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory infections, and systemic diseases such as diabetes. Most inhaled medicines could be cleared rapidly from the lungs and their therapeutic effects are transit. The inhaled medicines with extended pulmonary exposure may not only improve the patient compliance by reducing the frequency of drug administration, but also enhance the clinical benefits to the patients with improved therapeutic outcomes. This article systematically reviews the physical and chemical strategies to extend the pulmonary exposure of the inhaled medicines. It starts with an introduction of various physiological and pathophysiological barriers for designing inhaled medicines with extended lung exposure, which is followed by recent advances in various strategies to overcome these barriers. Finally, the applications of the inhaled medicines with extended lung exposure for the treatment of various diseases and the safety concerns associated to various strategies to extend the pulmonary exposure of the inhaled medicines are summarized.

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Section: Factors Influencing the Pulmonary Exposure Of The Inhaled Medicinesmentioning

confidence: 99%

Section: Strategies To Extend the Pulmonary Exposure Of The Inhaled Medicinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Guo

Bera

Shi

et al. 2021

Acta Pharmaceutica Sinica B

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“…This potentially explains the drug concentration in the lungs still detected after intratracheal administration instead of intravenous administration at 720 min, which could be better for the treatment of PAH. Previously, Hu et al reported that the spray dried nanocrystals of curcumin acetate, with long retention in the lungs, can be an effective treatment in a rat model of monocrotaline-induced PAH (Hu et al, 2017).…”

Section: In Vivo Studiesmentioning

confidence: 99%

DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment

Qiao

Cheng-Hao

et al. 2020

Drug Delivery

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“…Inhalable curcumin particles has been recently reported in few studies as dry powder inhalers using different methods, such as supercritical CO2-assisted spray-drying [10,56], supercritical anti-solvent (SAS) precipitation [57], spray and freeze drying [11], mechanical milling followed by spray drying [12,48], nanocomposite particles [13], polymeric micelle based [14,47]. Several studies have reported the use of liquid-based vehicles (liposomes and Janus nanoparticles) in preparing curcumin formulations for potentially treating lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of nanoemulsion and microsuspension formulations of curcuminoids for lung delivery with a novel approach to understanding the aerosol performance of nanoparticles

ayoub

Gopalan

Najafzadeh

et al. 2019

International Journal of Pharmaceutics

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Extensive research has demonstrated the potential effectiveness of curcumin against various diseases, including asthma and cancers. However, few studies have used liquid-based vehicles in the preparation of curcumin formulations. Therefore, the current study proposed the use of nanoemulsion and microsuspension formulations to prepare nebulised curcuminoid for lung delivery. Furthermore, this work expressed a new approach to understanding the aerosol performance of nanoparticles compared to microsuspension formulations. The genotoxicity of the formulations was also assessed. Curcuminoid nanoemulsion formulations were prepared in three concentrations (100, 250 and 500 µg/ml) using limonene and oleic acid as oil phases, while microsuspension solutions were prepared by suspending curcuminoid particles in isotonic solution (saline solution) of 0.02% Tween 80. The average fine particle fraction (FPF) and mass median aerodynamic diameter (MMAD) of the nebulised microsuspension formulations ranged from 26% and 7.1 µm to 40% and 5.7 µm, for 1000 µg/ml and 100 µg/ml respectively. In a comparison of the low and high drug concentrations of the nebulised nanoemulsion, the average FPF and MMAD of the nebulised nanoemulsion formulations prepared with limonene oil ranged from 50% and 4.6 µm to 45% and 5.6 µm, respectively; whereas the FPF and MMAD of the nebulised nanoemulsion prepared with oleic acid oil ranged from 46% and 4.9 µm to 44% and 5.6 µm, respectively. The aerosol performance of the microsuspension formulations were concentration dependent, while the nanoemulsion formulations did not appear to be dependent on the curcuminoids concentration. The performance and genotoxicity results of the formulations suggest the suitability of these preparations for further inhalation studies in animals.

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Curcumin Acetate Nanocrystals for Sustained Pulmonary Delivery: Preparation, Characterization and In Vivo Evaluation

Cited by 30 publications

References 0 publications

Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment

Development and evaluation of nanoemulsion and microsuspension formulations of curcuminoids for lung delivery with a novel approach to understanding the aerosol performance of nanoparticles

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