Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial

Srivilai, Jukkarin; Phimnuan, Preeyawass; Jaisabai, Jiraporn; Luangtoomma, Nantakarn; Waranuch, Neti; Khorana, Nantaka; Wisuitiprot, Wudtichai; Scholfield, C.N.; Champachaisri, Katechan; Ingkaninan, Kornkanok

doi:10.1016/j.phymed.2016.12.007

Cited by 27 publications

(30 citation statements)

References 20 publications

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“…Skin penetration of minoxidil with EO, hexane extract, and germacrone was enhanced 20-fold, 4-fold, and 10-fold, respectively [ 30 ]. In a randomized, double-blinded trial, C. aeruginosa rhizome EO formulated as a lotion (1% and 5% w / w EO) was reported to safely and effectively slow the growth of axillary hair and to rapidly and robustly increase axillary skin brightness (within three weeks) [ 206 ]. Interestingly, these effects persisted for two weeks after ending the treatment.…”

Section: Biological Activities Of Curcuma Oilsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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Members of the genus Curcuma L. have been used in traditional medicine for centuries for treating gastrointestinal disorders, pain, inflammatory conditions, wounds, and for cancer prevention and antiaging, among others. Many of the biological activities of Curcuma species can be attributed to nonvolatile curcuminoids, but these plants also produce volatile chemicals. Essential oils, in general, have shown numerous beneficial effects for health maintenance and treatment of diseases. Essential oils from Curcuma spp., particularly C. longa, have demonstrated various health-related biological activities and several essential oil companies have recently marketed Curcuma oils. This review summarizes the volatile components of various Curcuma species, the biological activities of Curcuma essential oils, and potential safety concerns of Curcuma essential oils and their components.

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Section: Biological Activities Of Curcuma Oilsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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“…However, some other chemical constituents in CA-ext might have been acting through other targets, which required further investigation. The reduction of hair growth with C. aeruginosa essential oil was evaluated previously [15]; however, the percentage hair growth reduction effect of the essential oil (16% on average) was lower than CA-ext (22% on average). The GC-MS analysis showed that the sesquiterpene content in CA-ext (80.7% total) was more abundant than in the essential oil (59.5% total), even though HPLC analysis revealed that the content of germacrone was more predominant in essential oil (22.4%) than CA-ex (6.3%).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, we reported that C. aeruginosa essential oil slowed hair growth in a randomised, double-blinded trial [15]. Here, we sought to demonstrate that CA-ext could inhibit axillary hair growth in 30 women recruited into a 12-week randomised, double-blind trial by application to 1 axilla while treating the contralateral armpit with a look-alike placebo using roll-on applicators.…”

Section: Introductionmentioning

confidence: 99%

Sesquiterpene-Enriched Extract of <b><i>Curcuma aeruginosa</i></b> Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

Srivilai¹,

Nontakhot²,

Nutuan³

et al. 2018

Skin Pharmacol Physiol

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Background: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. Methods: Thirty women (age 20–52 years) were recruited into a 12-week, double-blind, placebo-controlled intervention for CA-ext treatment, where they were randomly allocated to a left or right armpit group. At weekly intervals, axillary hair length was measured videometrically, the hair was shaved, and lotion was applied (to the contralateral axilla) twice daily via roll-on applicators containing either CA-ext or placebo. The primary endpoint of the study was hair growth. Results: Participants showed 22% (range 8–56%, p < 0.0001) reduced axillary hair growth with CA-ext compared to placebo, albeit delayed by 6 weeks. Participants were satisfied with the treatment and no apparent adverse effects were reported. The quantities of lotion used for each axilla were identical between test and placebo throughout the trial for each participant. Participants reported having shorter and finer armpit hair with the test lotion but disliked its smell, even though it was perfumed. The “free of irritation” description gained the highest questionnaire ratings. Conclusion: CA-ext in lotion is an efficacious inhibitor of axillary hair growth, the preparation was well accepted and matched the effectiveness of finasteride. Thus, with some refinement, it should provide an alternative pharmacological treatment for unwanted androgenic hair.

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“…The C. aeruginosa rhizome is used in folk medicine, including the treatment of rheumatic, asthma, enteritis, stomach pain, obesity, increase appetite, and obesity (Nurcholis et al,016a). Numerous works have reported the biological activity of C. aeruginosa, including its antimicrobial (Kamazeri et al, 2012;Akarchariya et al, 2017), anticancer (Fitria et al, 2019), antioxidant (Nurcholis et al, 016b, 2017), skin lightening, hairgrowth (Srivilai et al, 2017), anti-dengue (Moektiwardoyo et al, 2014), anti-androgenic (Suphrom et al, 2012) and uterine relaxant (Thaina et al, 2009) properties. Previous works have founded the presence of various metabolites such as germacrene, camphor (Akarchariya et al, 2017), curcuminoid (Nurcholis et al, 016a, 2019), cycloisolongifolene, 8,9-dihydro formyl, dihydrocostunolide (Kamazeri et al, 2012), terpenoids (Simoh and Zainal, 2015), and sesquiterpenes (Takano et al, 1995;Suphrom et al, 2012;Awin et al, 2019) in the C. aeruginosa extract.…”

Section: Introductionmentioning

confidence: 99%

Box-Behnken experimental design for extraction optimization of cytotoxic activity from Curcuma aeruginosa rhizome

Khoiriyah

Artika

Nurcholis

2020

ijrps

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Curcuma aeruginosa is the common name of temu hitam in Indonesia, and the rhizome parts of the plant have several pharmacological activities. Generally, pharmacological activities are associated with bioactive content in the extract of medicinal plants. Several factors can in luence the bioactive extraction from medicinal plants such as solvent types, extraction time, extraction technique, and liquid-to-solid ratio. In this research, the extraction factors for extraction yield and cytotoxic activity of C. aeruginosa rhizome were optimized using the Box-Behnken experimental design. Effect of ethanol concentration, the ratio of liquid to solid, and extraction time for the maceration process was studied. The cytotoxic activity was determined by the brine shrimp lethality test. The optimum value that maximizes the extraction yield was 70% ethanol, 300:15 ml/g liquid to solid ratio, and 1-day extraction time. The optimum value that maximizes the cytotoxic activity was 70% ethanol, 150:15 ml/g liquid to solid ratio, and 2-day extraction time. The predicted extraction yield and cytotoxic activity at these projected values are 14.78% and 78.26 mg/l, respectively. In this model, Adeq Precision (10.35 and 4.16), R-Squared (0.86 and 0.79), and F-value (7.92 and 2.04) is rational to it the model for extraction yield and cytotoxic activity from C. aeruginosa rhizome.

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Curcuma aeruginosa Roxb. essential oil slows hair-growth and lightens skin in axillae; a randomised, double blinded trial

Cited by 27 publications

References 20 publications

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Sesquiterpene-Enriched Extract of <b><i>Curcuma aeruginosa</i></b> Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

Box-Behnken experimental design for extraction optimization of cytotoxic activity from Curcuma aeruginosa rhizome

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