Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Dosoky, Noura S.; Setzer, William N.

doi:10.3390/nu10091196

Cited by 300 publications

(254 citation statements)

References 246 publications

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“…Zingiberaceae; chloroplast genome; phylogenetic analysis; single nucleotide polymorphism Curcuma zedoaria, commonly known as 'zedoary' and 'white turmeric' in English and 'ezhu' in Chinese, is an important Curcuma with an ancient medicinal history in China and Japan, where the plant is used as a carminative and stomachic (Branney 2005;Dosoky and Setzer 2018). The essential oil of zedoary essential oil is used in the perfume and liquor industries, and the bitter-tasting rhizome is used in the preparation of some curry powders and eaten as a vegetable in Thailand (Branney 2005).…”

Section: Curcuma Zedoaria;mentioning

confidence: 99%

Characterization and phylogenetic analysis of the complete chloroplast genome of Curcuma zedoaria (Zingiberaceae)

Zhu

et al. 2020

Mitochondrial DNA Part B

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The first complete chloroplast genome of Curcuma zedoaria (Zingiberaceae) was reported in this study. The C. zedoaria chloroplast genome was 162,135 bp in length, and consisted of one large single-copy (LSC) region of 86,966 bp, one small single-copy (SSC) region of 15,737 bp, and a pair of inverted repeat (IR) regions 29,716 bp. It encoded 141 genes, including 87 protein-coding genes (79 PCG species), 46 tRNA genes (28 tRNA species), and 8 rRNA genes (4 rRNA species). The phylogenetic analysis based on single nucleotide polymorphisms strongly supported that C. zedoaria, Curcuma roscoeana, Curcuma longa, and Stahlianthus involucratus clustered together in group Curcuma II within the family Zingiberaceae.

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Section: Curcuma Zedoaria;mentioning

confidence: 99%

Characterization and phylogenetic analysis of the complete chloroplast genome of Curcuma zedoaria (Zingiberaceae)

Zhu

et al. 2020

Mitochondrial DNA Part B

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“…On the basis of phytochemical studies on Curcuma oils, sesquiterpenoids, and monoterpenoids have been identified as the major active constituents. The essential oil of Curcuma species is reported to possess a wide range of pharmacological activities such as anti‐inflammatory, antiproliferative, hypocholesterolaemic, antidiabetic, diuretic, antirheumatic, hypotensive, antioxidant and cyclooxygenase‐1 (COX‐1) inhibitory activities (Dosoky et al, ). Curcuma zedoaria has been investigated for its effect on CYP3A4 enzymes in a Caco‐2 cell model treated with methanolic extract of rhizome for a period of 72 h. The extract considerably decreased the activity of CYP3A4 by 85–98% (IC 50 : 0.014 mg/ml) (Hou et al, ).…”

Section: Herbs Postulated To Induce Hdi With Cardiovascular Drugsmentioning

confidence: 99%

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Shaikh

Thomas

Chitlange

2020

Phytotherapy Research

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About 70% of the world population is currently using medicinal herbs as complementary or alternative medicine, which is increasing at a tremendous pace in both developed and developing countries in the last two decades (World Health Organization Medicines Strategy 2002–2005). This increase in consumer demand of medicinal herbs continues despite the rarity of scientific data to establish their safety and efficacy profile. Its popularity is also attributed to several factors, including easy availability, cost effectiveness leading to better purchasing power and general perception that they are safe. Herbs are often administered concomitantly with therapeutic drugs for the treatment of major ailments, raising the potential for herb–drug interactions (HDIs). The major pathways postulated for HDIs involves the cytochrome P450 (CYP450)‐mediated inhibition or induction and transport and efflux proteins. In our review, we highlight frequently used herbal medicines for the treatment of cardiovascular disorders (CVD), their established HDIs studied using in vitro tools and in vivo pharmacokinetic and pharmacodynamic assays and case reports. Herbs have been divided into different sections on the basis of availability of HDI data in relevance to cardiovascular drugs: herbs reported to interact with cardiac drugs, herbs yet to be reported for interaction with drugs of any class and herbs reported to interact with drugs of other therapeutic category but not with cardiac drugs. The amount of active phytoconstituents present in the selected herbs and their extent of bioavailability are also mentioned. This review can serve as a quick reference database for physicians and health care professionals involved in CVD treatment, aimed at maximizing clinical outcomes with reduction in adverse and toxic effects.

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“…Zedoary turmeric oil is a volatile oil extracted from Rhizoma Sparganii (RC). As an effective anti-tumor drug (Chang et al, 2019), the main active ingredients of zedoary turmeric oil are curcumin, curcumin diketone and β-elemene (Dosoky and Setzer, 2018).…”

Section: Rhizoma Curcumae and Rhizoma Sparganii (Rcrs) Is Frequently mentioning

confidence: 99%

Inhibition of Fibroblast Activation by Components of Rhizoma Curcumae and Rhizoma Sparganii in A Rat Model of Uterine Leiomyoma

Feng

Zhao

et al. 2020

Preprint

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Background: Traditional Chinese medicine (TCM) often uses Rhizoma Curcumae and Rhizoma Sparganii (RCRS) ，the natural herbs for the treatment of UL. RCRS has been shown to be effective in the treatment of UL in our previous study. This study was to investigate the molecular mechanism by which RCRS inhibits fibroblast activation protein (FAP) activation and prevents uterine leiomyoma in rats. Methods: The SD rat model of uterine leiomyoma was established by estrogen and progesterone load combined with external stimulation. Subsequently, histological analyses, enzyme-Linked immunosorbent assays, western blotting were performed to evaluate the effect of the drug on uterine leiomyoma and its mechanism. Results: Our data showed that treatment of rats with RCRS significantly reduced the expression of FAP, TGF-β (the FAP activating factor), and significantly decreased the phosphorylation of cell proliferation pathway-related signaling factors AKT/MEK/ERK, as well as the expression of the extracellular matrix component collagen. Conclusions: Our results showed that RCRS is very effective in prevention and treatment of uterine leiomyoma in rats, and RCRS may exert its actions by inhibiting the activation of tumor-associated fibroblasts, inhibiting the cell proliferation, and improving tumor extracellular matrix.

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Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Cited by 300 publications

References 246 publications

Characterization and phylogenetic analysis of the complete chloroplast genome of Curcuma zedoaria (Zingiberaceae)

Characterization and phylogenetic analysis of the complete chloroplast genome of Curcuma zedoaria (Zingiberaceae)

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Inhibition of Fibroblast Activation by Components of Rhizoma Curcumae and Rhizoma Sparganii in A Rat Model of Uterine Leiomyoma

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