Curative Effects of Gum Arabic and Boswellia Species on Acute Renal Failure in Experimental Rats

Mohamed, Reda N.; Tawfik, M. F.; Ibrahim, Hanan; Eldin, Mohamed Awad Tag; Hamada, Akinobu

doi:10.21608/ajs.2018.13917

Cited by 1 publication

(2 citation statements)

References 3 publications

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“…These results came in agreement with (Choudhury andAhmed, 2006, Saleh et al, 2014) who reported that cisplatin nephrotoxicity causes tubular damage and tubular dysfunction with sodium, potassium, and magnesium wasting, which may be resulted from the decrease in glomerular filtration rate. The curative effect of GA against renal injury is illustrated by the restoration of serum potassium levels as reported by (Ibrahim, 2014, Mohamed et al, 2018.…”

Section: Serum Potassium Levelmentioning

confidence: 76%

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Effect of Gum Arabic on Chemically Induced Acute Renal Injury in Albino Rats

Noha,

Fetaih²,

Dessouki³

2022

Egyptian Academic Journal of Biological Sciences, B. Zoology

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It has been concluded from several studies that Gum Arabic (GA) offers a protective effect as an anti-inflammatory and antioxidant agent against nephrotoxicity induced by some agents such as adenine and gentamicin. . In this study, the protective and/or treatment effect of GA against Cisplatin-induced acute nephrotoxicity in experimental rats were investigated through several biochemical, histological and immunohistochemical assessment of TGF-beta. Thirty male Wister albino rats were divided randomly into five groups, six rats in each. Group I (negative control), group II (GA) received 6% GA in drinking water, group III (Cisplatin) injected by CP (4.5 mg/kg b.w., i.p.) for two consecutive days, group IV (preventive) pretreated with GA 6% in drinking water daily for 4 weeks before Cisplatin injection and group V (treatment) co-treated by GA with Cisplatin injection (doses as mentioned before). Group III (Cisplatin) showed nephrotoxicity that was manifested by a significant increase in levels of serum Creatinine, urea, and potassium with elevation in kidney MDA level and a decrease in kidney GSH level. In addition, histopathological examination showed severe degeneration and necrosis in kidney tubules. These effects were significantly mitigated by GA administration in both groups IV and V, a result that proves the renoprotective effect of GA.

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Section: Serum Potassium Levelmentioning

confidence: 76%

“…Serum Urea and Creatinine concentrations were assessed spectrophotometrically according to the manufacturer's instructions by the methods of (Bonsnss andTaussky, 1945, Hallett andCook, 1971) and potassium (K+), analyzed by using commercially available kits according to the method of (Mohamed et al, 2018).…”

Section: Serum Biochemical Analysismentioning

confidence: 99%