Curative effect of picroliv on primary cultured rat hepatocytes against different hepatotoxins: an in vitro study

Visen, P. K. S.; Saraswat, Binduja; Dhawan, B. N.

doi:10.1016/s1056-8719(98)00052-5

Cited by 25 publications

(14 citation statements)

References 17 publications

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“…They are majorly localized within hepatocytes. Damage to the membrane of hepatocytes can cause these enzymes to leak out thereby leading to their elevation in the serum [23]. In this study, ALT, AST and ALP which were elevated by carbon tetrachloride were significantly reduced by the plant extract indicating hepatoprotection.…”

Section: Discussionmentioning

confidence: 50%

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Iseghohi

Orhue

2017

Clin Phytosci

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Background: Dennettia tripetala is a medicinal plant with in vitro antioxidant activities. It is capable of protecting the liver and kidney of rats from damage when administered prior to a single exposure of carbon tetrachloride. The aim of this study was to document the possible ameliorative effect of the aqueous extract of Dennettia tripetala fruits on rats subjected to multiple exposures of carbon tetrachloride. Methods: Carbon tetrachloride was administered orally to male albino rats of Wistar strain four times over a 2 week period. The aqueous extract of Dennettia tripetala fruits was administered daily for 7 days starting on the 8th day after carbon tetrachloride administration had commenced. Results: Carbon tetrachloride caused increases in serum ALT, AST and ALP, serum total cholesterol, serum LDLcholesterol, liver total cholesterol and triglyceride, serum total protein, globulin, urea, creatinine as well as liver and kidney malondialdehyde levels. Carbon tetrachloride also caused significant reductions in serum HDL-cholesterol, serum triglyceride, serum albumin:globulin ratio as well as liver and kidney SOD and catalase activities. The plant extract was able to restore the biochemical parameters to levels comparable to those of the control group in all instances. Further evidence in support of these results was derived from histopathological analysis. Conclusion: Taken together, the results of this study show that the aqueous extract of Dennettia tripetala fruits is able to ameliorate liver and kidney damage caused by multiple exposures to carbon tetrachloride probably via an antioxidant-dependent mechanism.

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Section: Discussionmentioning

confidence: 50%

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Iseghohi

Orhue

2017

Clin Phytosci

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“…These authors suggested that ursolic acid may prevent the initiation and propagation of the lipid peroxidation process by scavenging free radicals through conjugation with glutathione, leading to the control of oxidative damage and tissue protection. Inhibition of lipid peroxidation and increase of glutathione by oleanolic acid are proposed to play a role in preventing carbon tetrachloride-induced liver injury (Liu 1995;Visen et al 1998).…”

Section: Resultsmentioning

confidence: 99%

Trypanocidal activity and acute toxicity assessment of triterpene acids

et al. 2010

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The present study evaluates the in vitro and in vivo trypanocidal activity of ursolic acid and oleanolic acid against the Bolivia strain of Trypanosoma cruzi. Their acute toxicity is also assessed on the basis of median lethal dose (DL50) determination and quantification of biochemical parameters. Ursolic acid is the most active compound in vitro, furnishing IC50 of 25.5 microM and displaying 77% of trypomastigote lysis at a concentration of 128 microM. In agreement with in vitro assays, the results obtained for the in vivo assay reveals that ursolic acid (at a dose of 20 mg/Kg/day) provides the most significant reduction in the number of parasites at the parasitemic peak. Results concerning the LD50 assay and the biochemical parameters evaluated in the present study demonstrate that these substances can be safely used on an experimental basis.

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“…In the presence of oxygen, CCl 3 is quickly transformed into trichloromethyl peroxyl radical (CCl 3 O 2 ), CCl 3 O 2  binds covalently to cellular proteins or lipids, and initiates the lipid peroxidation in the cellular membrane (Levine and Reinhardt, 1983) resulting in the leakage of cellular enzymes (LDH, GPT and GOT) and finally cell apoptosis and necrosis (Manibusan et al, 2007). Therefore, cell viability and leakage of cytosolic enzymes (LDH, GPT and GOT) have been frequently used to assess the CCl 4 hepatotoxicity (Visen et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

In vitro protective effect of Schisandra chinensis extract against carbon tetrachlorideinduced hepatotoxicity in common carp (Cyprinus carpio)

Yin¹,

Wang²,

Cao³

et al. 2013

Afr. J. Pharm. Pharmacol.

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Curative effect of picroliv on primary cultured rat hepatocytes against different hepatotoxins: an in vitro study

Cited by 25 publications

References 17 publications

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Trypanocidal activity and acute toxicity assessment of triterpene acids

In vitro protective effect of Schisandra chinensis extract against carbon tetrachlorideinduced hepatotoxicity in common carp (Cyprinus carpio)

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