Curare

Bisset, N.G.

doi:10.1007/978-1-4612-2908-7_1

Cited by 7 publications

(3 citation statements)

References 232 publications

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“…During the last century, the chemical and pharmacological study of their active principles led to the discovery of famous medicines still used in western countries, the most convincing example of which being the different types of curare (Bisset, 1992a). Arrow and ordeal poisons are still considered today as conventional natural sources for future drug discovery (Tulp and Bohlin, 2004).…”

Section: Introductionmentioning

confidence: 99%

Recent developments in the field of arrow and dart poisons

Gilles

Angenot

2005

Journal of Ethnopharmacology

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Arrow and dart poisons, considered as conventional natural sources for future drug discovery, have already provided numerous biologically active molecules used as drugs in therapeutic applications or in pharmacological research. Plants containing alkaloids or cardiotonic glycosides have generally been the main ingredients responsible for the efficacy of these poisons, although some animals, such as frogs, have also been employed. This paper, without being exhaustive, reports the greater strides made during the past 15 years in the understanding of the chemical nature and biological properties of arrow and dart poison constituents. Examples both of promising biological properties shown by these molecules and of crucial discoveries achieved by their use as pharmacological tools are given. Further studies of these toxic principles are likely to enable scientists to find new valuable lead compounds, useful in many fields of research, like oncology, inflammation and infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Recent developments in the field of arrow and dart poisons

Gilles

Angenot

2005

Journal of Ethnopharmacology

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“…Many scientists have been fascinated by curare, and the chemical and pharmacological studies of the active principles led to the discovery of pharmacologically active compounds still used around the globe . Introduction of curare in clinical medicine in the first half of the last century represented a major breakthrough in the areas of anesthesia and surgery. − The use of curare permitted the development of the concept of the so-called “balanced anaesthesia”, in which the three components of general anesthesia, i.e., unconsciousness, analgesia, and muscle relaxation, are provided by separate drugs, e.g., thiopental, nitrous oxide, opioids, and curare.…”

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confidence: 99%

Curare Alkaloids: Constituents of a Matis Dart Poison

et al. 2015

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A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(-)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. D-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.

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“…(Loganiaceae) is a moderate-sized liana that occurs widely throughout the middle and upper Rio Orinoco basins and the entire Amazon basin. It is one of the most frequently collected species of this genus in South America and was the first botanically identified source of curare, of which it is a frequent ingredient. − In the 1950s, chemical investigation of the plant led to the isolation of small amounts of many colored alkaloidal products of unknown structure . We have reported the structures of guianensine and 9-methoxygeissoschizol from the tertiary alkaloidal fractions of the stem bark of S. guianensis .…”

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confidence: 99%