1999
DOI: 10.1021/np9804738
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Guiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark ofStrychnosguianensis

Abstract: A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by detailed spectroscopic methods and comparison with model compounds.

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Cited by 15 publications
(5 citation statements)
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“…Sabe-se hoje ser ela o famoso "Bejuco de Mavacure", citado por Humboldt no início do século XIX, como um dos principais ingredientes dos curares de Esmeralda, na Venezuela 4 . Estudos químicos recentes sobre esta espécie levaram ao isolamento de alcalóides quaternários [5][6][7][8] , justificando o seu freqüente emprego na preparação dos mencionados venenos.…”
Section: Introductionunclassified
“…Sabe-se hoje ser ela o famoso "Bejuco de Mavacure", citado por Humboldt no início do século XIX, como um dos principais ingredientes dos curares de Esmeralda, na Venezuela 4 . Estudos químicos recentes sobre esta espécie levaram ao isolamento de alcalóides quaternários [5][6][7][8] , justificando o seu freqüente emprego na preparação dos mencionados venenos.…”
Section: Introductionunclassified
“…These signals and the signal at d 4.03 suggested the presence of an indolic nucleus. [5][6][7] The signal at d 6.16 (d, Jϭ1.5 Hz) suggested the presence of a double bond in the structure of 1. The ϾCϭCH-CH 3 system was deduced from the signal at d 5.54 (q, Jϭ6.5 Hz, ϭCH-) coupled to the doublet at d 1.67 (Jϭ6.5 Hz, -CH 3 ) in the 1 H-1 H COSY (gradient correlate spectroscopy) spectrum.…”
Section: Resultsmentioning
confidence: 99%
“…The discovery of some of the recently inducted biologically important plant constituents is being summarized below: Guiaflavine (1) isolated from bark of Strychnos guinanesis, fissoldhimine (2) isolated from plant Fissistigma oldhamii and stachydrine (3) isolated from fruit of Capparis decidua. These compounds show various pharmacological activities [27][28][29] .…”
Section: Phytochemistry Department Activitiesmentioning
confidence: 99%
“…From Plumeria acutifolia, plumeriate (26), plumieride (27), plumerician (28), fulvoplumierin (29), plumeric acid (30), terpenoid derivatives and acetyl derivatives have been isolated [81][82][83][84] . Extract of this plant has antitumor and antimutagenic activity and is also known for anticancerous drug in folk medicine [85,86] .…”
Section: Phytochemistry Department Activitiesmentioning
confidence: 99%