Guiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark ofStrychnosguianensis

Penelle, Jacques; Tits, Monique; Christen, Philippe; Brandt, Viviane; Frédérich, Michel; Angenot, Luc

doi:10.1021/np9804738

Cited by 15 publications

(5 citation statements)

References 25 publications

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“…Sabe-se hoje ser ela o famoso "Bejuco de Mavacure", citado por Humboldt no início do século XIX, como um dos principais ingredientes dos curares de Esmeralda, na Venezuela 4 . Estudos químicos recentes sobre esta espécie levaram ao isolamento de alcalóides quaternários [5][6][7][8] , justificando o seu freqüente emprego na preparação dos mencionados venenos.…”

Section: Introductionunclassified

Lignanas de Strychnos guianensis (Aublet) Mart.

Pinheiro¹,

Rocha²,

Fernandes³

et al. 2004

Quím. Nova

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Section: Introductionunclassified

Lignanas de Strychnos guianensis (Aublet) Mart.

Pinheiro¹,

Rocha²,

Fernandes³

et al. 2004

Quím. Nova

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“…These signals and the signal at d 4.03 suggested the presence of an indolic nucleus. [5][6][7] The signal at d 6.16 (d, Jϭ1.5 Hz) suggested the presence of a double bond in the structure of 1. The ϾCϭCH-CH 3 system was deduced from the signal at d 5.54 (q, Jϭ6.5 Hz, ϭCH-) coupled to the doublet at d 1.67 (Jϭ6.5 Hz, -CH 3 ) in the 1 H-1 H COSY (gradient correlate spectroscopy) spectrum.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Strychnos pseudoquina St. Hil. Leaves Extract on Gastrointestinal Activity in Mice.

et al. 2005

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Alkaloids U 0600Evaluation of Strychnos pseudoquina St. Hil. Leaves Extract on Gastrointestinal Activity in Mice. -The new alkaloid (I) is isolated from the methanolic extract of leaves from S. pseudoquina together with rutin and kempferol 3-O-β-rutinoside. Both the polar and the enriched alkaloid fraction of the title plant reveal a significant anti-ulcer and cytoprotective effect on different induced gastric lesions with absence of toxicity by acute treatment. The anti-ulcer activity of the crude extract is almost as potent as that of the alkaloid-enriched fraction, thus indicating the possibility that further compounds may also contribute to the observed activity. -(APARECIDO DA SILVA, M.; MURINO RAFACHO, B. P.; HIRUMA-LIMA, C. A.; MACHADO DA ROCHA, L. R.; CAMPANER DOS SANTOS, L.; SANNOMIYA, M.; MONTEIRO SOUZA-BRITO, A. R.; VILEGAS*, W.; Chem. Pharm. Bull. 53 (2005) 8, 881-885;

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“…The discovery of some of the recently inducted biologically important plant constituents is being summarized below: Guiaflavine (1) isolated from bark of Strychnos guinanesis, fissoldhimine (2) isolated from plant Fissistigma oldhamii and stachydrine (3) isolated from fruit of Capparis decidua. These compounds show various pharmacological activities [27][28][29] .…”

Section: Phytochemistry Department Activitiesmentioning

confidence: 99%

“…From Plumeria acutifolia, plumeriate (26), plumieride (27), plumerician (28), fulvoplumierin (29), plumeric acid (30), terpenoid derivatives and acetyl derivatives have been isolated [81][82][83][84] . Extract of this plant has antitumor and antimutagenic activity and is also known for anticancerous drug in folk medicine [85,86] .…”

Section: Phytochemistry Department Activitiesmentioning

confidence: 99%

Chemical investigation of some biologically important plant constituents

2024

IJGHC

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Plants had been used for medicinal purposes long before recorded history. Ancient Chinese and Egyptian papyrus writings describe medicinal uses for plants as early as 3000 BC. Indigenous cultures (such as African and Native American) used herbs in their healing rituals, while others developed traditional medical systems (such as Ayurveda and Traditional Chinese Medicine) in which herbal therapies were used. Researchers found that people in different place of the world tended to use the same or similar plants for the same purposes. Ayurvedic medicines are used to cure several diseases as the herbs mentioned in ayurvedic texts are considered safe for human consumption. Indigenous plants have been used for thousands of years of ayurveda for its diverse healing properties. It is mentioned by Charak in the Charak Samhita, an ancient ayurvedic text.

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Guiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark ofStrychnosguianensis

Abstract: A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by detailed spectroscopic methods and comparison with model compounds.

Cited by 15 publications

References 25 publications

Lignanas de Strychnos guianensis (Aublet) Mart.

Lignanas de Strychnos guianensis (Aublet) Mart.

Evaluation of Strychnos pseudoquina St. Hil. Leaves Extract on Gastrointestinal Activity in Mice.

Chemical investigation of some biologically important plant constituents

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