CuO‐loaded hydrophobically modified chitosan as hybrid carrier for curcumin delivery and anticancer activity

Abstract

The hydrophobic modification of chitosan was performed by the incorporation of aromatic phendione to the amino group of chitosan to improve the hydrophobic drug encapsulation efficiency and anticancer activity. The phendione‐modified chitosan was coated with the copper oxide (CuO) nanoparticles to obtain the hybrid material for the model drug (curcumin) delivery. The synthesized hybrid nanoparticles were characterized by Fourier transform infrared, proton nuclear magnetic resonance, thermogravimetric analysis, X‐ray diffraction, atomic force microscopy, and scanning electron microscopy techniques. The extent of phendione modification on chitosan, presence of CuO nanoparticles, drug encapsulation, and size and morphology of the prepared hybrid materials were observed by using the techniques mentioned. The drug release studies were performed on simulated gastric fluid (pH 1.2) and simulated body fluid (pH 7.4) to analyze the release kinetics of curcumin from the chitosan and chitosan–phendione with CuO. The drug release was also monitored at different initial drug loading conditions. As the initial loading of drug decreased, the rate of drug release was also decreased. Mostly, the drug release followed a non‐Fickian, case II type transport mechanism. The drug‐loaded chitosan–phendione and chitosan with CuO nanoparticles were investigated for anticancer activities toward the cell lines M19‐MEL, MCF‐7, and HeLa. © 2017 Curtin University and John Wiley & Sons, Ltd.

Applying the Taguchi Method to the Optimization of Anticancer Activity of Bacterial Alginate-CuO Bionanocomposite

“…Also, all the studied factors (copper oxide nanoparticles, alginate biopolymer and stirring time) were effective on the anticancer activity of alginate-copper oxide nanocomposite. In agreement with the results obtained, previous studies have also reported the anticancer activity of copper oxide nanoparticles and the nanocomposites containing those [21], [22], [23]. Jeronsia et al ., [22] synthesised the copper oxide nanoparticles using the coprecipitation method and evaluated their anticancer activity at different levels against the MCF-7 cell line.…”

Synthesis, characterization, and thermal decomposition kinetics of copper hydroxide sulfate (Cu4(SO4)(OH)6) synthesized by chemical precipitation method

“…FTIR results are given in Figure 3. The peaks located at around 3,663, 3,588, 3,571, 3,384, 3,482, 2,972, and 2,886 cm −1 resembles to O–H stretching vibration, 28 and 1,150, 1,086, 1,071, 987, and 984 cm −1 resembles to asymmetric stretching vibrations of S–O bonds. The peaks at 873, 849, 780, and 748 cm −1 are due to bending vibrations of Cu–OH groups with different hydrogen bonds.…”

Biomass-Derived Dialdehyde Cellulose Cross-linked Chitosan-Based Nanocomposite Hydrogel with Phytosynthesized Zinc Oxide Nanoparticles for Enhanced Curcumin Delivery and Bioactivity

“…The curcumin release from the hydrogel was increased with increased curcumin loading concentrations because of an increased osmotic potential which leads to the release of more curcumin from the hydrogel into the release medium. 51 Kinetic Models. The curcumin release data from the nanocomposite hydrogel and pure chitosan−cellulose hydrogel obtained were applied to various kinetic models such as zero order, first order, Korsmeyer−Peppas, and Higuchi as shown in Figure S4.…”