Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer: supporting personalised screening

Román, Marta; Quintana, M. J.; Ferrer, Joana; Sala, María; Castells, Xavier

doi:10.1038/bjc.2017.107

Cited by 17 publications

(16 citation statements)

References 21 publications

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“…It is not currently known whether women with BBD are followed and screened more closely compared to women without BBD diagnoses. Current data from a study of over 42,000 screened women in Spain found that women with a previous benign breast disease diagnosis had a higher cumulative risk of screen-detected cancer and interval cancers, consistent with data supporting BBD as a risk factor for breast cancer regardless of the mode of detection [46]. Whether women with BBD in our cohort are more likely than the general population to participate in screening is not known but could be the subject of future research.…”

Section: Involution Statussupporting

confidence: 85%

Risk factors for breast cancer development by tumor characteristics among women with benign breast disease

et al. 2021

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Background Among women diagnosed with invasive breast cancer, 30% have a prior diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD patients that elevate invasive cancer risk. In the general population, risk factors differ in their associations by clinical pathologic features; however, whether women with BBD show etiologic heterogeneity in the types of breast cancers they develop remains unknown. Methods Using a nested case-control study of BBD and breast cancer risk conducted in a community healthcare plan (Kaiser Permanente Northwest), we assessed relationships of histologic features in BBD biopsies and patient characteristics with subsequent breast cancer risk and tested for heterogeneity of associations by estrogen receptor (ER) status, tumor grade, and size. The study included 514 invasive breast cancer cases (median follow-up of 9 years post-BBD diagnosis) and 514 matched controls, diagnosed with proliferative or non-proliferative BBD between 1971 and 2006, with follow-up through mid-2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using multivariable polytomous logistic regression models. Results Breast cancers were predominantly ER-positive (86%), well or moderately differentiated (73%), small (74% < 20 mm), and stage I/II (91%). Compared to patients with non-proliferative BBD, proliferative BBD with atypia conferred increased risk for ER-positive cancer (OR = 5.48, 95% CI = 2.14–14.01) with only one ER-negative case, P-heterogeneity = 0.45. The presence of columnar cell lesions (CCLs) at BBD diagnosis was associated with a 1.5-fold increase in the risk of both ER-positive and ER-negative tumors, with a 2-fold increase (95% CI = 1.21–3.58) observed among postmenopausal women (56%), independent of proliferative BBD status with and without atypia. We did not identify statistically significant differences in risk factor associations by tumor grade or size. Conclusion Most tumors that developed after a BBD diagnosis in this cohort were highly treatable low-stage ER-positive tumors. CCL in BBD biopsies may be associated with moderately increased risk, independent of BBD histology, and irrespective of ER status.

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Section: Involution Statussupporting

confidence: 85%

Risk factors for breast cancer development by tumor characteristics among women with benign breast disease

et al. 2021

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show abstract

“…It is not currently known whether women with BBD are followed and screened more closely compared to women without BBD diagnoses. Current data from a study of over 42,000 screened women in Spain found that women with a previous benign breast disease diagnosis had a higher cumulative risk of screen-detected cancer and interval cancers, consistent with data supporting BBD as a risk factor for breast cancer regardless of mode of detection [46]. Whether women with BBD in our cohort are more likely than the general population to participate in screening is not known but could be the subject of future research.…”

Section: Involution Statussupporting

confidence: 85%

Risk factors for breast cancer development by tumor characteristics among women with benign breast disease

Figueroa

Gierach²,

Duggan

et al. 2021

Preprint

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Background: Among women diagnosed with invasive breast cancer, 30% have a prior diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD patients that elevate invasive cancer risk. In the general population, risk factors differ in their associations by clinical pathologic features; however, whether women with BBD show etiologic heterogeneity in the types of breast cancers they develop remains unknown. Methods: Using a nested case-control study of BBD and breast cancer risk conducted in a community healthcare plan (Kaiser Permanente Northwest), we assessed relationships of histologic features in BBD biopsies and patient characteristics with subsequent breast cancer risk and tested for heterogeneity of associations by estrogen receptor (ER) status, tumor grade and size. The study included 514 invasive breast cancer cases (median follow-up of 9 years post-BBD diagnosis) and 514 matched controls, diagnosed with proliferative or non-proliferative BBD between 1971-2006, with follow-up through mid-2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using multivariable polytomous logistic regression models. Results: Breast cancers were predominantly ER-positive (86%), well- or moderately-differentiated (73%), small (74% <20mm) and stage I/II (91%). Compared to patients with non-proliferative BBD, proliferative BBD with atypia conferred risk for ER-positive (OR=5.48, 95%CI=2.14-14.01) with only one ER-negative case); p-heterogeneity=0.45. Presence of columnar cell lesions (CCLs) at BBD diagnosis was associated with a 1.5-fold increase in risk of both ER-positive and ER-negative tumors, with a 2-fold increase (95%CI=1.21-3.58) observed among postmenopausal women (56%), independent of proliferative BBD status with and without atypia. We did not identify statistically significant differences in risk factor associations by tumor grade or size. Conclusion: Most tumors that developed after a BBD diagnosis in this cohort were highly treatable low-stage ER-positive tumors. CCL in BBD biopsies may be associated with moderately increased risk, independent of BBD histology, and irrespective of ER status.

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“…Cancer is a multifactorial disease, and benign breast diseases are one of the most important risk factors for breast cancer 5,49,96. The results of a cohort study indicated that benign breast diseases are associated with an increased risk of ER-positive and ER-negative invasive breast cancer, and the rate of this increase is different in different age 94.…”

Section: Risk Factorsmentioning

confidence: 99%

<p>Epidemiological characteristics of and risk factors for breast cancer in the world</p>

Momenimovahed¹,

Salehiniya²

2019

BCTT

669

471

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Aim Breast cancer is the most common cancer among women and one of the most important causes of death among them. This review aimed to investigate the incidence and mortality rates of breast cancer and to identify the risk factors for breast cancer in the world. Materials and methods A search was performed in PubMed, Web of Science, and Scopus databases without any time restrictions. The search keywords included the following terms: breast cancer, risk factors, incidence, and mortality and a combination of these terms. Studies published in English that referred to various aspects of breast cancer including epidemiology and risk factors were included in the study. Overall, 142 articles published in English were included in the study. Results Based on the published studies, the incidence rate of breast cancer varies greatly with race and ethnicity and is higher in developed countries. Results of this study show that mortality rate of breast cancer is higher in less developed regions. The findings of this study demonstrated that various risk factors including demographic, reproductive, hormonal, hereditary, breast related, and lifestyle contribute to the incidence of breast cancer. Conclusion The results of this study indicated that incidence and mortality rates of breast cancer is rising, so design and implementation of screening programs and the control of risk factors seem essential.

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Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer: supporting personalised screening

Cited by 17 publications

References 21 publications

Risk factors for breast cancer development by tumor characteristics among women with benign breast disease

Risk factors for breast cancer development by tumor characteristics among women with benign breast disease

Risk factors for breast cancer development by tumor characteristics among women with benign breast disease

<p>Epidemiological characteristics of and risk factors for breast cancer in the world</p>

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