Cumulative dyslipidemia with arterial stiffness and carotid IMT progression in asymptomatic adolescents: A simulated intervention longitudinal study using temporal inverse allocation model

Agbaje, Andrew O; Lloyd-Jones, Donald M; Magnussen, Costan G.; Tuomainen, Tomi‐Pekka

doi:10.1016/j.atherosclerosis.2022.11.011

Cited by 22 publications

(38 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arterial stiffness and carotid intima‐media thickness (cIMT) have been associated with cardiometabolic morbidity and mortality 1–9 . However, whether longitudinal exposure to physical activity (PA) and sedentary (ST) confers long‐term vascular health benefits during growth from childhood until early adulthood is unclear 10–12 .…”

Section: Introductionmentioning

confidence: 99%

“…Arterial stiffness and carotid intima-media thickness (cIMT) have been associated with cardiometabolic morbidity and mortality. [1][2][3][4][5][6][7][8][9] However, whether longitudinal exposure to physical activity (PA) and sedentary (ST) confers long-term vascular health benefits during growth from childhood until early adulthood is unclear. [10][11][12] Due to the paucity of longitudinal accelerometer movement behavior measures in the pediatric population, findings of simulated replacements of ST with time spent in PA in relation to metabolic health have been employed in formulating PA guidelines.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children

Agbaje,

Barker,

Lewandowski

et al. 2024

Acta Physiologica

Self Cite

View full text Add to dashboard Cite

AimsWe examined the longitudinal associations of sedentary time (ST), light physical activity (LPA), and moderate‐to‐vigorous PA (MVPA) from childhood with carotid‐femoral pulse wave velocity (cfPWV), a measure of arterial stiffness and carotid intima‐media thickness (cIMT).MethodsWe studied 1339 children, aged 11 years from Avon Longitudinal Study of Parents and Children, UK, followed up for 13 years. Accelerometer‐based ST, LPA, and MVPA were assessed at ages 11, 15, and 24 years clinic visits. cfPWV and cIMT were measured with Vicorder and ultrasound, respectively, at ages 17 and 24 years.ResultsAmong 1339 [56.4% female] participants, mean ST increased from ages 11 through 24 years, while mean LPA and MVPA decreased. Persistently high ST tertile from childhood was associated with increased cfPWV progression, effect estimate 0.047 m/s; [(95% CI 0.005 to 0.090); p = 0.030], but not cIMT progression. Persistently high LPA tertile category was associated with decreased cfPWV progression in males −0.022 m/s; [(−0.028 to −0.017); p < 0.001] and females −0.027 m/s; [(−0.044 to −0.010); p < 0.001]. Cumulative LPA exposure decreased the odds of progressively worsening cfPWV [Odds ratio 0.994 (0.994–0.995); p < 0.0001] and cIMT. Persistent exposure to ≥60 min/day of MVPA was paradoxically associated with increased cfPWV progression in males 0.053 m/s; [(0.030 to 0.077); p < 0.001] and females 0.012 m/s; [(0.002 to 0.022); p = 0.016]. Persistent exposure to ≥60 min/day of MVPA was inversely associated with cIMT progression in females −0.017 mm; [(−0.026 to −0.009); p < 0.001].ConclusionLPA >3 h/day from childhood may attenuate progressively worsening vascular damage associated with increased ST in youth.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children

Agbaje,

Barker,

Lewandowski

et al. 2024

Acta Physiologica

Self Cite

View full text Add to dashboard Cite

show abstract

“…This finding suggests that earlier puberty may not have a major impact on preclinical cardiovascular risk in early adulthood 46 . In the present study, all participants had attained puberty by age 17 years of cardiac measures 22 . In youth athletes, LV dilatation and mild concentric LV hypertrophy have been reported in cardiac adaptation to exercise training 45 .…”

Section: Discussionmentioning

confidence: 55%

“…Participants with ≥130 mmHg systolic BP were categorized as elevated systolic BP/hypertension 21 . Fasting blood sample was assayed for high‐density lipoprotein cholesterol, triglyceride, insulin, glucose, high‐sensitivity C‐reactive protein, and estimated low‐density lipoprotein cholesterol at age 17 years 19,20,22 . Total body fat mass and lean mass were assessed using a dual‐energy x‐ray absorptiometry scanner at the clinic visit.…”

Section: Methodsmentioning

confidence: 99%

“…Participants provided a family history of hypertension, diabetes, high cholesterol, and vascular disease at the clinic visit. The participant's mother's socioeconomic status was grouped according to the 1991 British Office of Population and Census Statistics classification 22,24,25 . Time (years) to age at peak height velocity, an objective measure of pubertal or maturation status without having to rely on physical examination or self‐report, was derived using Superimposition by Translation And Rotation mixed‐effects growth curve analysis in the ALSPAC cohort 26 .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Associations of accelerometer‐based sedentary time, light physical activity and moderate‐to‐vigorous physical activity with resting cardiac structure and function in adolescents according to sex, fat mass, lean mass, BMI, and hypertensive status

Agbaje

2023

Scandinavian Med Sci Sports

Self Cite

View full text Add to dashboard Cite

Background This study examined the independent relationships of device‐based measured sedentary time (ST) and physical activity (PA) in relation to cardiac structural and functional geometry among adolescents. Methods From the Avon Longitudinal Study of Parents and Children, UK birth cohort, 530 (50% female) adolescents aged 17 years had complete ST, PA, cardiac, and covariate measures. Echocardiography cardiac measures were left ventricular mass indexed for height2.7 (LVMI2.7), relative wall thickness, LV diastolic function (LVDF), and LV filling pressure (LVFP). Overweight/obesity and elevated systolic/BP hypertension were categorized as body mass index >24.99 kg/m2 and ≥130 mmHg, respectively. Data were analyzed with linear regression models adjusting for cardiometabolic factors and lifestyle factors. Results The prevalence of overweight/obesity in males and females was 17.9% and 24.5%, respectively. The prevalence of elevated systolic BP/hypertension was 11.6% in males and 1.1% among females. The average ST was 484 ± 78 min/day, light PA was 274 ± 62 min/day, and moderate‐to‐vigorous PA (MVPA) was 41 ± 24 min/day, among females. Average ST, LPA, and MVPA were 468 ± 87 min/day, 293 ± 70 min/day, and 56 ± 30 min/day, respectively, among males. Higher ST was associated with higher LVMI2.7 (standardized β = 0.16; p = 0.01) among females, but higher ST was associated with lower LVDF in males (β = −0.14; p = 0.04). Higher ST and MVPA were associated with higher LVMI2.7 in the total cohort, normal weight, and overweight/obese adolescents. Light PA was associated with higher LVDF in the total cohort and normotensives and lower LVFP among adolescents with high lean mass. Conclusions Higher ST and MVPA were associated with higher LVMI; however, ST‐associated LVMI increase was threefold higher than MVPA‐associated LVMI increase. Higher LPA was associated with better cardiac function. Reducing ST and increasing LPA may attenuate the risk of altered cardiac structure and function in adolescents.

show abstract

Early Vascular Aging in the Young

Urbina,

Nilsson,

McEniery

2024

Early Vascular Aging (EVA)

View full text Add to dashboard Cite

Cumulative dyslipidemia with arterial stiffness and carotid IMT progression in asymptomatic adolescents: A simulated intervention longitudinal study using temporal inverse allocation model

Cited by 22 publications

References 36 publications

Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children

Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children

Associations of accelerometer‐based sedentary time, light physical activity and moderate‐to‐vigorous physical activity with resting cardiac structure and function in adolescents according to sex, fat mass, lean mass, BMI, and hypertensive status

Early Vascular Aging in the Young

Contact Info

Product

Resources

About