Cultured meat on a plant-based frame

Young, Jette F.; Skrivergaard, Stig

doi:10.1038/s43016-020-0053-6

Cited by 17 publications

(12 citation statements)

References 6 publications

(5 reference statements)

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“…There is a high demand for replacements for animal tissues for these reasons, in addition to ethical and scientific considerations, and decellularized plant materials could also be further investigated to this end. This point is further emphasized by the use of decellularized vegetal tissues as three-dimensional scaffolds on which to culture bovine skeletal muscle cells for the production of cultured meat [113][114][115][116]. In this way, the scaffolds are edible and support cell growth, while reducing costs, the need for livestock, and the occurrence of food-borne illnesses.…”

Section: Additional Considerations For Decellularized Plant-based Biomaterialsmentioning

confidence: 99%

The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial

Harris

Lacombe

Zenhausern

2021

IJMS

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The decellularization of plant-based biomaterials to generate tissue-engineered substitutes or in vitro cellular models has significantly increased in recent years. These vegetal tissues can be sourced from plant leaves and stems or fruits and vegetables, making them a low-cost, accessible, and sustainable resource from which to generate three-dimensional scaffolds. Each construct is distinct, representing a wide range of architectural and mechanical properties as well as innate vasculature networks. Based on the rapid rise in interest, this review aims to detail the current state of the art and presents the future challenges and perspectives of these unique biomaterials. First, we consider the different existing decellularization techniques, including chemical, detergent-free, enzymatic, and supercritical fluid approaches that are used to generate such scaffolds and examine how these protocols can be selected based on plant cellularity. We next examine strategies for cell seeding onto the plant-derived constructs and the importance of the different functionalization methods used to assist in cell adhesion and promote cell viability. Finally, we discuss how their structural features, such as inherent vasculature, porosity, morphology, and mechanical properties (i.e., stiffness, elasticity, etc.) position plant-based scaffolds as a unique biomaterial and drive their use for specific downstream applications. The main challenges in the field are presented throughout the discussion, and future directions are proposed to help improve the development and use of vegetal constructs in biomedical research.

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Section: Additional Considerations For Decellularized Plant-based Biomaterialsmentioning

confidence: 99%

The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial

Harris

Lacombe

Zenhausern

2021

IJMS

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“…The geometries present in plant cellulose are being used to grow meat on, making for an even greener solution for the meat industry. There is also an example of growing meat, or skeletal muscle, on textured soy protein, but this strategy requires extra steps for fabrication of the scaffold that are overcome in decellularized plant-based scaffolds by the use of architecture naturally present in plant tissue . It is apparent that the world is leaning toward more sustainable alternatives in medicine and agriculture, and plants are an abundant and ideal source for various applications such as tissue regeneration or meat agriculture.…”

Section: Discussionmentioning

confidence: 99%

Plant-Based Scaffolds in Tissue Engineering

Bilirgen

Toker

Odabaş

et al. 2021

ACS Biomater. Sci. Eng.

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A wide range of platforms has been developed for 3D culture of cells in vitro to aggregate and align cells to resemble in vivo conditions in order to enhance communication between cells and promote differentiation. The cellulose skeleton of plant tissue can serve as an attainable scaffold for mammalian cells after decellularization, which is advantageous when compared to synthetic polymers or animal-derived scaffolds. Adjustable variables to modify the physical and biochemical properties of the resulting scaffolds include the protocol for the sodium dodecyl sulfate (SDS)-based decellularization procedure, surface coatings for cell attachment, plant type for decellularization, differentiation media, and integrity and shape of the substrate. These tunable cellulose platforms can host a wide range of mammalian cell types from muscle to bone cells, as well as malignancies. Here, fundamentals and applications of decellularized plant-based scaffolds are discussed. These biocompatible, naturally perfused, tunable, and easily prepared decellularized scaffolds may allow eco-friendly manufacturing frameworks for application in tissue engineering and organs-on-a-chip.

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“…Under the present land sparing scenarios, no energy intake loss is due to occur as costs per Mcal produced decrease (Figure 6). This is of essence to the current consensus where studies attempt to enhance global food security through the utilisation of crop-based solutions (Aiking, 2011;Day, 2013;Young and Skrivergaard, 2020). Naturally, as the optimisation spatially reallocated agricultural systems globally, parts of the globe would rely on trade to achieve production inputs sufficiency (fertiliser) along with feed sufficiencyfactors that affect food security in far deeper ways than merely yield gaps (Savary et al, 2012), which calls for robust global supply chains to assure resilience and constant food supply (Seekell et al, 2017;Cole et al, 2018;Kinnunen et al, 2020).…”

Section: Global Food Supply Implicationsmentioning

confidence: 99%

Restoring Nature at Lower Food Production Costs

Vittis

Folberth

Bundle

et al. 2021

Front. Environ. Sci.

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Growing competition for land, water and energy call for global strategies ensuring affordable food production at minimum environmental impacts. Economic modelling studies suggest trade-off relationships between environmental sustainability and food prices. However, evidence based on empirical cost-functions supporting such trade-offs remains scarce at the global level. Here, based on cost engineering modelling, we show that optimised spatial allocation of 10 major crops, would reduce current costs of agricultural production by approximately 40% while improving environmental performance. Although production inputs per unit of output increase at local scales, a reduction of cultivated land of 50% overcompensates the slightly higher field-scale costs enabling improved overall cost-effectiveness. Our results suggest that long-run food prices are bound to continue to decrease under strong environmental policies. Policies supporting sustainability transitions in the land sector should focus on managing local barriers to the implementation of high-yield regenerative agricultural practices delivering multiple regional and global public goods.

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Cultured meat on a plant-based frame

Cited by 17 publications

References 6 publications

The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial

The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial

Plant-Based Scaffolds in Tissue Engineering

Restoring Nature at Lower Food Production Costs

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