Cultured Epithelial Autografts for the Management of a Chronic Pretibial Leg Ulcer due to Congenital Valvular Aplasia

Slonková, Veronika; Kino‐oka, Masahiro; Mazza, Salvador; Nievergelt, C.; Prenosil, J. E.; Burg, Günter; Hanfer, J.

doi:10.1159/000018079

Cited by 5 publications

(2 citation statements)

References 9 publications

(4 reference statements)

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“…Bilateral pretibial ulcers in a young patient with congenital valvular aplasia, an unusual and difficult cause of leg ulcers, were treated with CEAs 36 . This treatment induced wound healing from the wound edges and demonstrated that CEA may work to stimulate wound healing on top of its own contribution to wound closure.…”

Section: Methodsmentioning

confidence: 99%

Clinical Indications of Cultured Epithelial Autografts

Dhar,

Chrisman,

Simman

2023

Ann Plast Surg

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Cultured epithelial autografts (CEAs) have been used for decades as a treatment for massive burn injuries. Cultured epithelial autografts allow for wounds to heal by taking a small sample and growing a patient's own epithelium in culture to create large, graftable sheets. This technique is especially useful in large wounds where donor sites are limited compared with conventional skin grafting. However, CEAs have a variety of uses in wound healing and reconstruction and have the potential to aid in the closure of several types of defects. Cultured epithelial autografts have shown applicability in large burns, chronic nonhealing wounds, ulcerating wounds of various etiologies, congenital defects, wounds requiring specialized epithelium to replace like by like, and wounds in critically ill patients. Several factors must be considered when using CEAs, such as time, cost, and outcomes. In this article, we detail the various clinical applications of CEAs and how they can be situationally advantageous outside of their original purpose.

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Section: Methodsmentioning

confidence: 99%

Clinical Indications of Cultured Epithelial Autografts

Dhar,

Chrisman,

Simman

2023

Ann Plast Surg

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“…Isolated keratinocytes are serially subcultured and then expanded by in vitro procedures into sheets of epidermis over a period of 2–3 weeks. Lethally irradiated 3T3 cells may be used as a feeder layer 3,15 . The advantages of this method are that it is autologous; it is possible to cover large areas with sheets from one small skin biopsy, resulting in permanent wound coverage with acceptable cosmetic results and allowing cryopreservation of cells for future use 16 .…”

Section: Introductionmentioning

confidence: 99%

Cryopreserved and lyophilized cultured epidermal allografts in the treatment of leg ulcers: a pilot study

Navrátilová¹,

Slonková²,

Semrádová³

et al. 2004

Acad Dermatol Venereol

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The cryopreserved and lyophilized cultured allografts are comparable in healing rate, course of healing and relief of pain, and also in planimetric changes during the healing of venous leg ulcers. Lyophilized allografts are more convenient for routine use than cryopreserved allografts as they can be stored at room temperature. These results could give rise to the more frequent use of lyophilized allografts in slow-healing venous leg ulcers.

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Ulceration Resulting from Disorders of the Veins and Arteries

Hafner,

Rabe

2024

Rook's Textbook of Dermatology

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This chapter describes the diagnosis and treatment of the four major variants of chronic leg ulcers with a macrovascular origin: venous leg ulcers; mixed venous and arterial leg ulcers; arterial leg ulcers; and Martorell hypertensive ischaemic leg ulcers. The majority of patients with chronic ulcers can be treated effectively and healed. This, however, requires standardised work‐up and treatment planning. The text highlights the hallmarks of vascular leg ulcers and suggests algorithms to successful management.

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Cultured Epithelial Autografts for the Management of a Chronic Pretibial Leg Ulcer due to Congenital Valvular Aplasia

Cited by 5 publications

References 9 publications

Clinical Indications of Cultured Epithelial Autografts

Clinical Indications of Cultured Epithelial Autografts

Cryopreserved and lyophilized cultured epidermal allografts in the treatment of leg ulcers: a pilot study

Ulceration Resulting from Disorders of the Veins and Arteries

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