Culture Proven Endogenous Bacterial Endophthalmitis in Apparently Healthy Individuals

Shankar, Karthick; Lamichhane, Gyanendra; Sharma, Himanshu; Narayan, Shah Dev

doi:10.3109/09273940903216891

Cited by 29 publications

(14 citation statements)

References 12 publications

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“…The most frequently seen pathogen was Staphylococcus aureus (6/19, accounted for 31.5%), followed by Streptococcus pneumoniae (3/19, 15.7%), and Pseudomonas aeruginosa (3/19, 15.7%) (Table 4). In other countries of South East Asia, the most common bacterium were Gram negative rods Klebsiella from hepatobiliary infections 7,19. In Europe and North America, the most common isolates were Gram positive cocci like Staphylococcus and Streptococcus from arthritis and endocarditis 8,19,21,22…”

Section: Discussionmentioning

confidence: 99%

Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone

D¹,

Hon²,

Aung³

et al. 2014

OPTH

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Background/aimsTo compare treatment outcomes with and without silicone oil tamponade in patients undergoing pars plana vitrectomy (PPV) for severe endogenous bacterial endophthalmitis (BEE).MethodsOne hundred and eight consecutive patients with severe BEE (defined by the absence of pupil red reflex at presentation and/or dense vitreous opacity on ultrasound and no improvement after 24–36 hours of medical treatment) were randomly assigned to two treatment groups: Group 1, standard PPV with intravitreal antibiotics; and Group 2, PPV with intravitreal antibiotics and silicone tamponade. Overall success was defined as: a visual acuity ≥ count fingers at 1 meter, with an attached retina, and no intraocular oil.ResultsFifty three patients were randomized to Group 1 and 55 patients to Group 2. The mean age of study subjects was 32 years and baseline clinical characteristics were similar in both groups. At the final follow-up visit at 9 months, the overall success rate of Group 2 (67.3%) was significantly better than Group 1 (43.4%; P=0.01). There were also fewer devastating complications (such as inoperable retinal detachment, phthisis bulbi) in Group 2 compared with Group 1 (21.8% versus 43.4%; P=0.01).ConclusionThe outcome at 9 months of patients with BEE treated by vitrectomy with silicone oil was better than those treated by vitrectomy alone.

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Section: Discussionmentioning

confidence: 99%

Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone

D¹,

Hon²,

Aung³

et al. 2014

OPTH

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“…Of note was the lack of substantial inflammation and better intraocular clarity in vancomycin-treated eyes, suggesting some beneficial level of anti-inflammatory activity. Vancomycin does not have anti-inflammatory activity per se, but can affect PMN phagocytic and chemotactic function 40,41 and inhibit proinflammatory cytokine responses in vitro 42,43 . If PMN recruitment or chemotaxis in the eye are affected by vancomycin, inflammation may be arrested during infection.…”

Section: Discussionmentioning

confidence: 99%

“…Underlying risk factors associated with an immunocompromised state are highly associated with cases of endogenous endophthalmitis, with only a limited number of the cases reported in otherwise healthy individuals [11,41,42]. The risk factors themselves are broad and range from underlying diabetes mellitus to infection with HIV [8,11,39,40,43].…”

Section: The Danger Of Systemic Infectionsmentioning

confidence: 99%

Improved Therapeutic Regimens for Treatment of Post-Traumatic Ocular Infections

Callegan¹

2008

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY) 22-05-2008 REPORT TYPE SAMS Monograph SPONSOR/MONITOR'S ACRONYM(S)FMSO / CGSC SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)Foreign SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENT Approved for Public Release; Distribution is Unlimited SUPPLEMENTARY NOTES ABSTRACTThe 21 st century security environment poses challenges to military paradigms that have existed for generations. Events around the world demonstrate how military forces are increasingly assisting in a variety of civil crises and national emergencies using different methods and working with agencies with which there was limited or no interaction in the past. Joint and interagency operations are becoming the norm and an integral part of successful operations across the spectrum of conflict, and will continue into the near future. The ability of the Australian Defence Force (ADF) to work across organizations, leveraging and promoting interoperability across the community has been the focus of an unprecedented effort to gain a truly "Whole of Government Approach" for over thirty years. The crux of whole of government operations lies in achieving interoperability between the highly-structured military organizations staffed by trained professionals and less-rigid civilian agencies focused around individual motivations. A look at the synthesis between the organizations involved within the Australian whole of government approach in comparison with the United States' unified action doctrine demonstrates an increased operational flexibility practiced by this relatively small organization. The 21 st century security environment poses challenges to military paradigms that have existed for generations. Events around the world demonstrate how military forces are increasingly assisting in a variety of civil crises and national emergencies using different methods and working with agencies with which there was limited or no interaction in the past. Joint and interagency operations are becoming the norm and an integral part of successful operations across the spectrum of conflict, and will continue into the near fut...

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Section: The Danger Of Systemic Infectionsmentioning

confidence: 99%

Severe bacterial endophthalmitis: towards improving clinical outcomes

Novosad

Callegan

2010

Expert Review of Ophthalmology

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Endophthalmitis is an infection and inflammation of the interior of the eye that can result in significant vision loss. This infection occurs as a result of the seeding of organisms into the interior of the eye following surgery (postoperative), trauma (post-traumatic) or an infection in another site in the body (endogenous). The general rate of endophthalmitis has remained steady over the past several years. However, the increased use of intraocular injections to treat various degenerative and inflammatory ocular diseases, in addition to the already large and growing number of invasive ocular surgeries, may increase the opportunities in which organisms can gain access to the eye. In most cases of endophthalmitis, useful vision can be retained if proper treatment is instituted. However, in severe cases of bacterial endophthalmitis, blindness often occurs despite treatment. This article summarizes information on endophthalmitis epidemiology, treatment issues and current regimens, and recent experimental and clinical efforts to improve the outcome of severe and blinding forms of bacterial endophthalmitis.

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Culture Proven Endogenous Bacterial Endophthalmitis in Apparently Healthy Individuals

Cited by 29 publications

References 12 publications

Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone

Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone

Improved Therapeutic Regimens for Treatment of Post-Traumatic Ocular Infections

Severe bacterial endophthalmitis: towards improving clinical outcomes

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