Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone

D, Tan; Hon, Do Nhu; Aung, Tin; Hien, Nguyen Dtn; Cowan, Claude L.

doi:10.2147/opth.s67589

Cited by 16 publications

(25 citation statements)

References 21 publications

(48 reference statements)

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“…(2003) or Do et al. (2014) showed no significant differences for the analysis of RRD. However, the I 2 analysis in the majority of the comparisons showed moderate heterogeneity in the pooled studies, indicating the effect of different tamponades in control groups.…”

Section: Resultsmentioning

confidence: 92%

Complications associated with the use of silicone oil in vitreoretinal surgery: A systemic review and meta‐analysis

Valentín-Bravo

García-Onrubia

Andrés-Iglesias

et al. 2021

Acta Ophthalmologica

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Silicone oil (SO) still represents the main choice for long‐term intraocular tamponade in complicated vitreoretinal surgery. This review compared the complications associated with the use of SO and other vitreous substitutes after pars plana vitrectomy in patients with different underlying diseases. Meta‐analysis was conducted in accordance with PRISMA guidelines. We retrieved randomized clinical trials (RCTs), retrospective case–control and cohort studies evaluating the risk of using SO, published between 1994 and 2020, conducting a computer‐based search of the following databases: PubMed, Web of Science, Scopus and Embase. Primary outcome was the rate of complications such as intraocular hypertension, retinal re‐detachment, unexpected vision loss or hypotony. Secondary outcome was to compare the rate of adverse events of different SO viscosities, especially emulsification. Forty‐three articles were included. There were significant differences in intraocular hypertension (p = 0.0002, OR = 1.66; 95% CI = 1.27–2.18) and the rate of retinal re‐detachment (p < 0.0009, OR = 0.65; 95% CI = 0.50–0.64) between SO and other agents, including placebo. However, there were no differences in other complication rates. Silicone oil (SO)‐emulsification rate was non‐significantly higher in low than high SO viscosity, and results from other complications were comparable in both groups. The high quality of most of the studies included in this study is noteworthy, which provides some certainty to the conclusions. Among them is the high variability of the SO residence time. The fact that ocular hypertension and not hypotension is related to SO use. A clear relationship is not found for the so‐called unexplained vision loss, which affects a significant percentage of eyes. Re‐detachment cases are less if SO is used and that surprisingly there does not seem to be a relationship in the percentage of emulsification between the low‐ and high‐viscosity silicones. All these data warrant more standardized prospective studies.

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Section: Resultsmentioning

confidence: 92%

Complications associated with the use of silicone oil in vitreoretinal surgery: A systemic review and meta‐analysis

Valentín-Bravo

García-Onrubia

Andrés-Iglesias

et al. 2021

Acta Ophthalmologica

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“…Ratra et al found a significantly improved chance for anatomical and functional success with vitrectomy [ 7 ]. In a randomized trial performed on bacterial EE cases, silicone oil endotamponade has significantly increased the rate of success at 9 months [ 82 ]. In a case series of EFE, VA increased by 2 lines in 25% of eyes after intravitreal injections and in 71% of eyes after vitrectomy plus intravitreal injections [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Endogenous Endophthalmitis: A Review of Case Series Published between 2011 and 2020

Danielescu

Anton

Stanca

et al. 2020

Journal of Ophthalmology

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This is a literature review of 31 case series of endogenous endophthalmitis (EE) published in the last ten years, identified from a literature search of several databases (PubMed, EMBASE, and the Cochrane Library). While diabetes mellitus and malignancies remain the most frequently associated medical conditions, intravenous drug use is a significant risk factor (especially in the last years, in studies from Western countries). Ophthalmologic screening is recommended for candidaemia, but not in patients with sepsis of other aetiologies (however, the physician treating patients with sepsis must be well aware of EE). The most frequent Gram-positive microorganisms that cause EE are Staphylococcus and Streptococcus; the most frequent Gram-negative organism is Pseudomonas, and yeasts, probably Candida, usually cause fungal infections. In all-cause EE, prognostic factors of better visual outcomes are initial VA better than counting fingers, performing a pars plana vitrectomy (PPV), performing an intravitreal injection within the first 24 hours after clinical diagnosis, and the presence of a focal type of EE. In endogenous fungal endophthalmitis, more than 1/4 of patients have bilateral involvement. Blood samples have a low rate of positivity. Yeasts remain the most prevalent cause. Many authors report using azoles and echinocandins for systemic therapy (and voriconazole for intravitreal injections). Although PPV was performed in small proportions of eyes, the anatomical success rate is quite high. Klebsiella pneumoniae is an important cause of EE in Southeast Asia (and probably an emergent etiology in other regions), which is frequently associated with diabetes. There is a robust association with pyogenic liver abscess (PLA) (but in up to half of the cases, the diagnosis of EE precedes that of PLA). Blood cultures have a high diagnostic yield, while vitreous samples have a low yield. K. pneumoniae may carry antibiotic resistance. Anatomical and functional success rates are small, but they may be improved with PPV.

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“…They found that the overall success rate defined as visual acuity ≥ counting fingers at 1 meter, attached retina, without silicone oil at 9 months follow up was higher in the silicone oil group than the vitrectomy alone group. 57 …”

Section: Endogenous Bacterial Endophthalmitismentioning

confidence: 99%

Infectious Uveitis

Lin

2015

Curr Ophthalmol Rep

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Infectious uveitis is one of the most common and visually devastating causes of uveitis in the US and worldwide. This review provides a summary of the identification, treatment, and complications associated with certain forms of viral, bacterial, fungal, helminthic, and parasitic uveitis. In particular, this article reviews the literature on identification and treatment of acute retinal necrosis due to herpes simplex virus, varicella virus, and cytomegalovirus. While no agreed-upon treatment has been identified, the characteristics of Ebola virus panuveitis is also reviewed. In addition, forms of parasitic infection such as Toxoplasmosis and Toxocariasis are summarized, as well as spirochetal uveitis. Syphilitic retinitis is reviewed given its increase in prevalence over the last decade. The importance of early identification and treatment of infectious uveitis is emphasized. Early identification can be achieved with a combination of maintaining a high suspicion, recognizing certain clinical features, utilizing multi-modal imaging, and obtaining specimens for molecular diagnostic testing.

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Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone

Cited by 16 publications

References 21 publications

Complications associated with the use of silicone oil in vitreoretinal surgery: A systemic review and meta‐analysis

Complications associated with the use of silicone oil in vitreoretinal surgery: A systemic review and meta‐analysis

Endogenous Endophthalmitis: A Review of Case Series Published between 2011 and 2020

Infectious Uveitis

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