Culture-Directed Topical Antibiotic Treatment for Chronic Rhinosinusitis

Abstract

(mean 4.9 [CI 4.3, 5.6] to mean 4.1 [CI 3.5, 4.7

The effect of medical treatments on the bacterial microbiome in patients with chronic rhinosinusitis: a pilot study

“…Therefore, therapies which even temporarily promote dysbiosis, without contributing to improved long‐term outcomes, may not be helpful. Antibiotics prescribed to patients based on culture‐based studies have shown reductions in culture rates following therapy . The more recent studies of changes in bacterial communities following systemic medical therapies have described complex community shifts, which were unpredictable, often involving increases in the relative abundance of Staphylococcus and a number of dominant taxa .…”

Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial

“…Other studies have focused on topical antibiotics to target other biofilm‐forming bacteria, such as Pseudomonas aeruginosa , with varying results . Recently, 1 study showed modest success in using topical antibiotics for CRS . However, given the small number of studies and concerns regarding relapse and development of resistance over time, the routine use of mupirocin and other topical antibiotics remains controversial .…”

Development of bacterial resistance during treatment with topical gentamicin for chronic rhinosinusitis in patients with cystic fibrosis and primary ciliary dyskinesis. Retrospective case series

“…ing in terms of reduced symptoms, endoscopic appearance and the need for repeat surgeries [2,32]. Nevertheless, in non-operated patients, the outcomes of topical antibiotics were less beneficial in CF compared to non-CF [33]. In the present study none of the patients were treated with endoscopic sinus surgery before treatment with gentamicin spray.…”