Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial

Lee, Victoria S.; Humphreys, Ian; Purcell, Patricia; Davis, Greg E.

doi:10.1002/alr.21898

Cited by 42 publications

(34 citation statements)

References 33 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although several studies have attempted to assess the potential role of honey in the treatment of CRS with variable results, they highlight the potential that exists for examination of alternative and naturally occurring therapies that might ultimately provide significant benefit. [73][74][75]…”

Section: Manuka Honey and Other Nonantibiotic Approaches To Dysbiosismentioning

confidence: 99%

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

Gurrola

Borish

2017

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

It is increasingly recognized that chronic rhinosinusitis (CRS) comprises a spectrum of different diseases with distinct clinical presentations and pathogenic mechanisms. Defining the distinct phenotypes and endotypes of CRS affects prognosis and, most importantly, is necessary as the basis for making therapeutic decisions. The need for individualized definitions of pathogenic mechanisms before initiating therapy extends to virtually all therapeutic considerations. This is clearly crucial with antibiotics, where, barring an influence from their off-target anti-inflammatory pharmacologic effects, an understanding of the role of the individual biome predicts likelihood of therapeutic benefit. However, this need for identifying individual phenotypes and endotypes also extends to the agent that is currently considered the mainstay of treatment of CRS, specifically glucocorticoids. As with asthma, it is recognized that a large minority of patients with CRS have a steroid-resistant phenotype, identification of which will preclude use of these agents with their potential side effects. Identification of endotypes is also becoming increasingly imperative because targeted biotherapeutic agents, such as anti-IgE and anti-cytokine antibodies, are becoming available. These agents are likely to benefit patients in whom the targeted mediator is not only expressed but demonstrably driving a central mechanism in that patient. In summary, the treatment of CRS is at an exciting crossroad. On the positive side, numerous therapeutics are in development that seem likely to have a positive effect in our patients with this condition. The challenge is that these therapies will require targeted individualized treatments based on identifying subjects with the relevant endotype.

show abstract

Section: Manuka Honey and Other Nonantibiotic Approaches To Dysbiosismentioning

confidence: 99%

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

Gurrola

Borish

2017

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…The first randomized, controlled, single‐blinded trial investigating topical MH in recalcitrant CRS was conducted by Lee et al . Patients received 10% (wt/vol) MH with unspecified MGO content or saline sinus rinses twice daily for 30 days.…”

Section: Discussionmentioning

confidence: 99%

“…The study had been designed as a 14‐day treatment as we considered: (1) matching the duration of both treatment arms while we also set out to ascertain MH's minimum effective dose; and (2) the feasibility of patients transporting and storing >2 weeks of MH treatment (>6.7 L). We believe that the duration of MH treatment may need to be further optimized, especially taking into account the outcome of other studies using MH rinses for up to 4 weeks with more favorable microbiology results . Previous cohort studies with topical treatments for recalcitrant CRS, such as mupirocin rinses, are commonly used as a twice‐daily rinse over 3‐4 weeks …”

Section: Discussionmentioning

confidence: 99%

Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single‐blinded, placebo‐controlled trial

Ooi

Jothin

Bennett

et al. 2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background Manuka honey (MH) has significant antibiofilm activity in vitro and in vivo against Staphylococcus aureus, methicillin‐resistant S aureus (MRSA), and Pseudomonas aeruginosa. This is the first randomized, single‐blinded, placebo‐controlled phase 1 clinical trial investigating the safety and preliminary efficacy of MH with augmented methylglyoxal (MGO) rinses in recalcitrant chronic rhinosinusitis (CRS). Methods Patients were included after previously undergoing endoscopic sinus surgery and presenting with signs and symptoms of sinus infection with positive bacterial cultures on sinus swabs. Patients were randomized to receive 14 days of twice‐daily 16.5% MH + 1.3 mg/mL MGO sinonasal rinses and concurrent 10 days of placebo tablets (MH), or 14 days of twice‐daily saline sinonasal rinses and concurrent 10 days of culture‐directed antibiotic therapy (CON). Safety observations included the University of Pennsylvania Smell Identification Test (UPSIT) and adverse‐event (AE) reporting. Efficacy was assessed comparing microbiology results, Lund‐Kennedy scores (LKSs), and symptom scores using the visual analog scale (VAS) and 22‐item Sino‐Nasal Outcome Test (SNOT‐22). Results Twenty‐five patients completed the study. MH demonstrated a good safety profile with no major AEs and no changes in UPSIT. Six of 10 (60%) MH patients had a reduction in bacterial culture rate with 1 of 10 of those having negative cultures, compared with 12 of 15 (80%) in the control group with 7 of 15 having negative cultures upon completion of the study. Conclusion This study concludes that twice‐daily 16.5% MH augmented with 1.3 mg/mL MGO sinonasal rinses alone for 14 days is safe but not superior to culture‐directed oral antibiotics and twice‐daily saline rinses.

show abstract

“…MH (Manuka honey) was tested on patients complaining of chronic rhino-sinusitis prior to surgery and it did show a significant improvement and good outcomes (11).…”

Section: Introductionmentioning

confidence: 99%

Awareness of Medical Students at Al-Imam University of the Medical Uses and Benefits of Honey

2017

IJSR

View full text Add to dashboard Cite

Aim: To assess the knowledge of Al-Imam Mohamed Ibn Saud University, collage of medicine undergraduate students about complementary and prophet medicine in general. And the uses of honey in different medical specialty. Identifying weak areas since the complementary medicine is a block of 5 weeks length is added to the student's curriculum. To improve final outcome of the block. Prove that honey affect different aspect of health positively. Methodology: We conducted a cross sectional study were a total of 100 questioner where distributed over 100 undergraduatestudents. The undergraduate studentswere selected randomly (systemic random sampling) based on the attendance sheet of the first, second and third year in medical college in the first semester of 2013. We decided to take thirty percent of each year randomly. Repeated students were excluded from the sample and replaced by other student same method of choosing the other proved students. Result: Data were collected by a questioner filed by 100 undergraduate student from first, second and third year in collage of medicine at Al-Imam Mohammed Ibn Saud University. Collected data were analyzed later. The undergraduate students were subdivided based on their grade point average. 3-3.5/5 (10%), 3.5-4/5 (50%), 4-4.5/5 (25%) and >4.5/5 (15%). We found the 55% of the approved sample have good background about the honey usage and the benefits in different medical aspect. 40% of those who know honey benefits and medically uses use honey daily. The rest of the populations were ranging from one time per week to one time per month. Conclusion: honey has proved that if affect the health in different aspects and have proved that it can be used as an immune system builder, wound and burns healing, gastric disorders, sore throat, dental care, anti-cancer agent and weight loss diets. Since the study was done in Al-Imam Mohammed Ibn Saud University, collage of medicine. We found that more than 50 percent of the students have a fair knowledge about medical uses and benefits of honey, the higher the GPA the higher the knowledge. Also from our view as undergraduate student we see that we can improve the complementary medicine block outcome by converting most of the lecture given by doctors to seminars conducted by students to maximize the overall benefit. Conduct a problem base learning sections so the student have more chances to increase their knowledge while they are searching and reading for facts on a given subject.

show abstract

Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial

Cited by 42 publications

References 33 publications

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single‐blinded, placebo‐controlled trial

Awareness of Medical Students at Al-Imam University of the Medical Uses and Benefits of Honey

Contact Info

Product

Resources

About