INTRODUCTIONEmergency room is one of challenges rooms in regard to the resulting of distress and anxiety of patients and their relatives. The anxiety level in family members is varied, including depression. 1 The impact of distress and anxiety are destruction of communication among family members and these will result to inability to concentrate and insufficiency of coping mechanism.2 As a result, the changes of emotional status of the family members are ABSTRACT Background: Critical condition of patient is trigger to the increasing of anxiety of family members. This situation is vulnerable of ineffective nursing care services provide by nurses in emergency room. Communication is one of abilities which nurse have to performed, and is recognized not that simple in its implementation. This study aimed was to identify whether or not there is a relationship between communications performed by the nurses and the level of anxiety of family members of patient in Emergency Room dr. Dradjat Prawiranegara hospital, Serang Banten, Indonesia. Methods: This study was cross-sectional study with non-parametric analysis data used was Spearman's Rho. Data were collected through direct observation by 4 numerators and observational sheet of nurse's communication. Level of anxiety of family members was measuring by using State Trait Anxiety Inventory Y-1. Data were collected from 47 family members and 47 nurses who were selected by using accidental sampling technique. Results: The study revealed that nurses performed eye contact, well informed consent, quick respond to the needs of patient and family members, clear voice, understandable language, introducing them self, active listening and emphatic, calm and friendly. Regarding anxiety of family members, 42.6% of them were showing moderate level of anxiety, whereas 34.0% of them were showing low level of anxiety. In bivariate analysis by using Spearman's Rho showed that p value was 0.000 and coefficient correlation -0.765. It was indicated that there was significantly relationship between communication of emergency nurses and the level of anxiety of family members. It was indicated that the more effective the communication performed by nurses, the less the anxiety level of family members. Conclusions: Nurse is required to be able to perform their therapeutic communication skill effectively so that the anxiety level of family members is decreasing. As a result, the stable emotion of family members affect to the appropriate decision making of medical treatment.