Cuff and sieve electrode (CASE): The combination of neural electrodes for bi-directional peripheral nerve interfacing

Kim, Hyungsoo; Dingle, Aaron M.; Ness, Jared P.; Baek, Dong Hyun; Bong, Jihye; Lee, In Kyu; Shulzhenko, Nikita O.; Zeng, Weifeng; Israel, Jacqueline S.; Pisaniello, Jane A.; Millevolte, Augusto X.T.; Park, Dong Wook; Suminski, Aaron J.; Jung, Yei Hwan; Williams, Justin; Poore, Samuel O.; Ma, Zhenqiang

doi:10.1016/j.jneumeth.2020.108602

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…The cuff and sieve electrode (CASE) [131], an implant whose name is self-descriptive, exploits the tubular support present in regenerative implants by integrating additional extraneural recording sites on it. While CASEs are still very invasive because of the regenerative aspect, they can be easily implanted and can provide immediate recording feedback once in place thanks to the extraneural part.…”

Section: Hybrid Pnismentioning

confidence: 99%

Compliant peripheral nerve interfaces

et al. 2021

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Peripheral nerve interfaces (PNIs) record and/or modulate neural activity of nerves, which are responsible for conducting sensory-motor information to and from the central nervous system, and for regulating the activity of inner organs. PNIs are used both in neuroscience research and in therapeutical applications such as precise closed-loop control of neuroprosthetic limbs, treatment of neuropathic pain and restoration of vital functions (e.g. breathing and bladder management). Implantable interfaces represent an attractive solution to directly access peripheral nerves and provide enhanced selectivity both in recording and in stimulation, compared to their non-invasive counterparts. Nevertheless, the long-term functionality of implantable PNIs is limited by tissue damage, which occurs at the implant-tissue interface, and is thus highly dependent on material properties, biocompatibility and implant design. Current research focuses on the development of mechanically compliant PNIs, which adapt to the anatomy and dynamic movements of nerves in the body thereby limiting foreign body response. In this paper, we review recent progress in the development of flexible and implantable PNIs, highlighting promising solutions related to materials selection and their associated fabrication methods, and integrated functions. We report on the variety of available interface designs (intraneural, extraneural and regenerative) and different modulation techniques (electrical, optical, chemical) emphasizing the main challenges associated with integrating such systems on compliant substrates.

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Section: Hybrid Pnismentioning

confidence: 99%

Compliant peripheral nerve interfaces

et al. 2021

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“…published designs to combine both sieve and cuff interfaces (Kim et al, 2020) and maximize transit zones (MacEwan et al, 2016). The modifications did not impact surgical implantation and the animal recovered well and remained unremarkable throughout the 12-week experimental period.…”

Section: Resultsmentioning

confidence: 99%

Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones

et al. 2021

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Sieve electrodes stand poised to deliver the selectivity required for driving advanced prosthetics but are considered inherently invasive and lack the stability required for a chronic solution. This proof of concept experiment investigates the potential for the housing and engagement of a sieve electrode within the medullary canal as part of an osseointegrated neural interface (ONI) for greater selectivity toward improving prosthetic control. The working hypotheses are that (A) the addition of a sieve interface to a cuff electrode housed within the medullary canal of the femur as part of an ONI would be capable of measuring efferent and afferent compound nerve action potentials (CNAPs) through a greater number of channels; (B) that signaling improves over time; and (C) that stimulation at this interface generates measurable cortical somatosensory evoked potentials through a greater number of channels. The modified ONI was tested in a rabbit (n = 1) amputation model over 12 weeks, comparing the sieve component to the cuff, and subsequently compared to historical data. Efferent CNAPs were successfully recorded from the sieve demonstrating physiological improvements in CNAPs between weeks 3 and 5, and somatosensory cortical responses recorded at 12 weeks postoperatively. This demonstrates that sieve electrodes can be housed and function within the medullary canal, demonstrated by improved nerve engagement and distinct cortical sensory feedback. This data presents the conceptual framework for housing more sophisticated sieve electrodes in bone as part of an ONI for improving selectivity with percutaneous connectivity toward improved prosthetic control.

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“…Our work hints at the unexplored potential of mechanical FEM studies to evaluate innovative PNI designs, as we provide the first example of geometrical optimization to reduce induced stresses on the internal part of the nerve. While few examples of fabricated and tested hybrid implants are available in literature [63][64][65], our work highlights the potential of new designs to reduce the effect of mechanical mismatch and improve long term longevity. Moreover, the presence of an additional extraneural support layer has proven to be beneficial to the chronic mechanical stability of other intrafascicular implants such as the Utah Slanted Electrode Arrays [9,66].…”

Section: Discussionmentioning

confidence: 96%

A finite element model of the mechanical interactions between peripheral nerves and intrafascicular implants

et al. 2022

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Objective. Intrafascicular peripheral nerve implants are key components in the development of bidirectional neuroprostheses such as touch-enabled bionic limbs for amputees. However, the durability of such interfaces is hindered by the immune response following the implantation. Among the causes linked to such reaction, the mechanical mismatch between host nerve and implant is thought to play a decisive role, especially in chronic settings. Approach. Here we focus on modeling mechanical stresses induced on the peripheral nerve by the implant’s micromotion using finite element analysis. Through multiple parametric sweeps, we analyze the role of the implant’s material, geometry (aspect-ratio and shape), and surface coating, deriving a set of parameters for the design of better-integrated implants. Main results. Our results indicate that peripheral nerve implants should be designed and manufactured with smooth edges, using materials at most three orders of magnitude stiffer than the nerve, and with innovative geometries to redistribute micromotion-associated loads to less delicate parts of the nerve such as the epineurium. Significance. Overall, our model is a useful tool for the peripheral nerve implant designer that is mindful of the importance of implant mechanics for long term applications.

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Cuff and sieve electrode (CASE): The combination of neural electrodes for bi-directional peripheral nerve interfacing

Cited by 12 publications

References 33 publications

Compliant peripheral nerve interfaces

Compliant peripheral nerve interfaces

Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones

A finite element model of the mechanical interactions between peripheral nerves and intrafascicular implants

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