Cucurbitane Triterpenoids from the Fruit Pulp of Momordica charantia and Their Cytotoxic Activity

Abstract

Two new cucurbitane-type triterpenes, 25-methoxycucurbita-5,23(E)-diene-3b,19-diol (1) and 7b-ethoxy-3b-hydroxy-25-methoxycucurbita-5,23(E)-dien-19-al (2), together with three known cucurbitanetype triterpenes, 3b,7b,25-trihydroxycucurbita-5,23(E)-dien-19-al (3), (23E)-3b-hydroxy-7b,25-dimethoxycucurbita-5,23-dien-19-al (4), and 3b-hydroxy-25-methoxycucurbita-6,23(E)-dien-19,5b-olide (5), were isolated from the fruit pulp of Momordica charantia. The structures of two new compounds were elucidated on the basis of 1D and 2D NMR, MS, IR, optical rotation. Among these isolates, compounds 1, 2, and 5 showed slight cytotoxic activity against the SK-Hep 1 cell line with IC 50 values of 33.1, 24.3, and 38.7 mM, respectively.

Cytotoxic and Antitumoral Activities of Compounds Isolated from Cucurbitaceae Plants

“…CuE targets the dissemination of breast cancer cells from the primary tumor but not the outgrowth of established micrometastases in target organs (lung, liver, between others). CuE exerts no significant effect on tumor cell apoptosis or proliferation in vivo [19].…”

“…Two Table 1 [19,30]. 15', 17'-19', 21', 24'-29'. Cytotoxic and Antitumoral Activities of Compounds Isolated from Cucurbitaceae Plants DOI: http://dx.doi.org/10.5772/intechopen.82213…”

Impact of Extraction on Biochemical Properties and Antioxidant Potential of <i>Momordica charantia</i> L. Seeds’ Oil

“…Furthermore, the oil from the seeds of M. charantia may regenerate tissue without side effects in healing rabbit skin [10]. Likewise the consumption of mature and immature fruits increases the secretion of GLP-1 in order to control glucose homeostasis by incretin effect [11]. In other words, the alcoholic extracts of the seeds could also be used for the treatment of chronic leukemia [12].…”