Cubosomes of dapsone enhanced permeation across the skin

Nithya, R.; Jerold, Prince; Karthik, S.

doi:10.1016/j.jddst.2018.09.002

Cited by 47 publications

(21 citation statements)

References 25 publications

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“…The authors have explained these findings considering the characteristics of GMO and poloxamer 407, which may interact with skin lipids and form channels able to facilitate drug permeation. Although an enhanced skin permeation has been observed with cubosomes, drug deposition in the skin was not considered by the authors (125).…”

Section: Ultrasonication Of Cubic Gels In Watermentioning

confidence: 97%

“…Cubosomes are bicontinuous cubic liquid crystalline particles made of specific surfactants with a proper ratio of water, which microstructure provides unique properties (124). DAP-loaded cubosomes were developed via ultrasonication of aqueous dispersion containing cubic gel matrix of glyceryl monooleate and poloxamer 407 (125). High EE (82-93%) was achieved, especially in combinations of higher amount of glycerol monooleate (GMO) and lower amount of poloxamer 407.…”

Section: Ultrasonication Of Cubic Gels In Watermentioning

confidence: 99%

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Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone

2020

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Dapsone (DAP) is a long-established molecule that remains a promising therapeutic agent for various diseases mainly because it combines antimicrobial and antiinflammatory activities. Its oral application, however, is limited by the dose-dependent hematological side effects that may rise from systemic exposure. As an alternative to overcome this limitation, the administration of DAP to the skin has witnessed prominent interest in the past 20 years, particularly when applied to the treatment of dermatological disorders. In this review, all technological strategies proposed to the topical delivery of DAP are presented. Most of the reported studies have been devoted to the clinical use and safety of a gel formulation containing both solubilized and microcrystalline drug, however, the technological characteristics of such preparation are still missing. In parallel, the incorporation of DAP into vesicular and particulate carriers (e.g. nano-and microemulsions, niosomes, invasomes, bilosomes, cubosomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric nanocapsules and polymer-lipid-polymer hybrid nanoparticles) appears to be an alternative to provide greater drug release control, enhanced drug solubilization and follicular targeting. Indeed, the main application of DAP topical formulations reported in the literature was the treatment of acne vulgaris, a disease located in the hair follicle. Other diseases affecting different regions of the skin (e.g. cutaneous lupus erythematosus and cutaneous leishmaniasis), however, may also benefit from a topical therapeutic regimen containing DAP. Therefore, the investigation of appendageal route in comparison to passive transmembrane diffusion as a function of targeted disease, as well as pharmacokinetic studies, are perspectives highlighted herein. Such studies may drive future efforts towards the rational development of safe and effective technologies to deliver DAP to the skin.

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Section: Ultrasonication Of Cubic Gels In Watermentioning

confidence: 97%

Section: Ultrasonication Of Cubic Gels In Watermentioning

confidence: 99%

Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone

2020

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“…Following in vivo studies, it was found that transdermal application of colchicine cubosomal gel significantly improves the drug absorption compared with oral solution, with a 4.6-fold greater bioavailability. In addition, Nitha and Siram [ 94 ] demonstrated that cubosomes are able to enhance the permeation of dapsone through the skin as compared to marketed formulation and the corresponding free drug solution. Nonetheless, Boge and colleagues [ 95 ] evidenced that the antimicrobial peptide LL-37 could be proposed for topical delivery by mean of cubosomes.…”

Section: Lipid-based Nanosystemsmentioning

confidence: 99%

Lipid-Based Nanosystems as a Tool to Overcome Skin Barrier

Sguizzato

Esposito

Cortesi

2021

IJMS

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Skin may be affected by many disorders that can be treated by topical applications of drugs on the action site. With the advent of nanotechnologies, new efficient delivery systems have been developed. Particularly, lipid-based nanosystems such as liposomes, ethosomes, transferosomes, solid lipid nanoparticles, nanostructured lipid carriers, cubosomes, and monoolein aqueous dispersions have been proposed for cutaneous application, reaching in some cases the market or clinical trials. This review aims to provide an overview of the different lipid-based nanosystems, focusing on their use for topical application. Particularly, biocompatible nanosystems able to dissolve lipophilic compounds and to control the release of carried drug, possibly reducing side effects, are described. Notably, the rationale to topically administer antioxidant molecules by lipid nanocarriers is described. Indeed, the structural similarity between the nanosystem lipid matrix and the skin lipids allows the achievement of a transdermal effect. Surely, more research is required to better understand the mechanism of interaction between lipid-based nanosystems and skin. However, this attempt to summarize and highlight the possibilities offered by lipid-based nanosystems could help the scientific community to take advantage of the benefits derived from this kind of nanosystem.

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“…221,222 Cubosomes easily evacuate their contents to the epidermis as they have an almost same structure to that of the stratum corneum, as well as the properties of adhesion and penetration enhancement of cubosomes suggest their potential utility in skin cancer (melanoma) treatment. 223 On the highlight of this, very recently, a report of biocompatible polymer-free cubosomes for potential application in both photodynamic therapy and bioimaging of skin malignant melanoma has been published with very low cytotoxicity to the cutaneous formulation. 224 More examples of herbal loaded cubosome are shown in Table 1.…”

Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

128

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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Cubosomes of dapsone enhanced permeation across the skin

Cited by 47 publications

References 25 publications

Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone

Emerging Technologies to Target Drug Delivery to the Skin – the Role of Crystals and Carrier-Based Systems in the Case Study of Dapsone

Lipid-Based Nanosystems as a Tool to Overcome Skin Barrier

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

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