Cubosomes: A Novel Carrier for Transdermal Drug Delivery

Dhadwal, Avantika; Sharma, Dev Raj; Pandit, Vinay; Ashawat, Mahendra Singh; Kumar, Pravin

doi:10.22270/jddt.v10i1.3814

Cited by 36 publications

(26 citation statements)

References 36 publications

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“…These nanoparticles are self-assembled liquid crystallike units of surfactants with appropriate ratio of water with microstructure and also possess solid like flow properties. They have major ratio of bilayer particle volume and huge breaking resistance [11]…”

Section: Cubosmoesmentioning

confidence: 99%

Review on Transferosomes and Transferosomal Gels

Kumar

2021

JPRI

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Transdermal drug delivery systems (TDDS), which are self-administrable and non-invasive, can improve bioavailability and patient compliance by bypassing first-pass metabolism. Vesicular-based TDDS have attracted a lot of attention in recent years because they're designed for controlled, efficient, and targeted drug delivery. One of these delivery technologies, transferosomal-based formulations, has grown in popularity due to its ability to achieve all of the desired criteria and quality qualities. Transferosomes combine the characteristics of liposomes and niosomes because they contain both liposomes (phospholipids and cholesterols) and niosomes as components (nonionic surfactants; edge activators). as a result, they are referred to as the first generation of elastic liposomes. However transdermal drug delivery is difficult due to the presence of the skin's protective barrier, transferosomal drug delivery overcomes all obstacles due to its unique characteristics, such as its ultradeformable vesicular nature. The benefits, limitations, modes of penetration, formulations, production and assessment methodologies, and pharmaceutical uses of transferosomal drug delivery systems are discussed in this paper. Conclusion: Transferosomes have several importance over other vesicular systems, including greater deformability, greater penetration power across skin, the ability to deliver systemic drugs, and higher stability.

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Section: Cubosmoesmentioning

confidence: 99%

Review on Transferosomes and Transferosomal Gels

Kumar

2021

JPRI

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“…5. This method cannot avoid the forming of vesicles through cryo-TEM, many vesicle sized-like structures are also observed to be coexist with cubosomes [23][24][25][26][27][28][29]. In the preparation of drug-containing vesicles used by freeze-drying technique.…”

Section: Bottom-up Approachmentioning

confidence: 99%

“…Topical drug delivery systems are unique in-situ, which form bio-adhesive LC systems that facilitate controlled and effective drug delivery to mucosal surfaces like buccal, ophthalmic, vaginal and others. This system forms a thin surface film at mucosal surfaces for achieving an optimal delivery profile and has excellent temporary protection for sore throat and sensitive skin [23].…”

Section: Cubosomes For the Topical Routementioning

confidence: 99%

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Review on Cubosomes

Saritha¹,

Harshini²,

Kumari³

et al. 2021

Int J Curr Pharm Sci

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Cubosomes are stable nanostructured liquid crystalline particles which are made of a specific group of amphiphilic lipids in definite proper ratio in water and then stabilised by biocompatible substances like triblock polymer. Cubosomes are curved bicontinuous cubic phase liquid crystals and they can split to form thermodynamically stable particulate dispersions. Cubosomes have biocompatible and bio-adhesive properties andare capable of loading 3D bilayered structure resembling honeycomb (carvenous) like structure by encapsulating lipophilic, hydrophobic and amphiphilic substances. Cubosomes are administered through different ways such as orally, parenterally and percutaneously. Cubosomes are versatile systems in their structure for drug delivery systems.

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“…Cubosomes can incorporate high drug payloads because the cubic structure has a high internal surface area. [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Investigating nanostructured liquid crystalline particles as prospective ocular delivery vehicle for tobramycin sulfate: Ex vivo and in vivo studies

Kaul

Nagaich

Verma

2021

J Adv Pharm Technol Res

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Tobramycin remains the anchor drug for bacterial keratitis treatment and management; however, unlike other aminoglycosides, it does not pass through the gastrointestinal tract. The aim of the current investigation was to formulate tobramycin-loaded nanostructured liquid crystalline particles as an ophthalmic drug delivery system to ameliorate its preocular residence duration and ophthalmic bioavailability. Tobramycin cubosomes were fabricated by liquid–lipid monoolein, water, and poloxamer 407 as a stabilizer. Corneal penetration studies exhibited that the apparent permeation coefficient of tobramycin cubosomes was nearly 3.6-fold greater than marketed tobramycin eye drops. Ocular in vivo analysis performed in rabbits' eyes manifested that the intensity of bacterial keratitis was reduced on day 3, and on day 5, the manifestations were considerably mitigated with tobramycin cubosomes as compared to marked eye drops. Pharmacokinetic study of rabbit aqueous humor demonstrated that the area under curve and the peak concentration of optimized cubosomes were 3.1-fold and 3.3-fold, respectively, which was significantly higher than marketed eye drops. Moreover, histopathological studies illustrated the existence of normal ocular structures, thus indicating that there was no damage to the corneal epithelium or stromal layer. Consequently, the results acquired demonstrated that tobramycin-loaded cubosomal formulation could be a propitious lipid-based nanodelivery system that would enhance retention time and corneal permeability contrast to commercial eye drops.

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Cubosomes: A Novel Carrier for Transdermal Drug Delivery

Cited by 36 publications

References 36 publications

Review on Transferosomes and Transferosomal Gels

Review on Transferosomes and Transferosomal Gels

Review on Cubosomes

Investigating nanostructured liquid crystalline particles as prospective ocular delivery vehicle for tobramycin sulfate: Ex vivo and in vivo studies

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