Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis

. Design of the study, acquisition of data, critical revising and final approval of the version to be published. ABSTRACT PURPOSE:This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS:The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. RESULTS: CONCLUSION:These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.

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“…The Cu/Zn ratio has been correlated with nutritional status in institutionalized elderly 8 and patients under peritoneal dialysis 9 .…”

Section: Introductionmentioning

confidence: 99%

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

et al. 2016

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“…Their absorption decreases in cases of malabsorption and malnutrition [20,21]. Similarly, Zn/Cu ratio is an indication of malabsorption and it decreases in cases of protein energy malnutrition, malabsorption, and chronic systemic illnesses [22,23]. In our study, evaluation of patients did not reveal indications of malnutrition and malabsorption; Zn/Cu, Se/Albumin, and Cu/Albumin levels were normal.…”

Section: Discussionmentioning

confidence: 65%

Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Yalaki¹,

Özdemir²,

Zengin³

et al. 2017

Dicle Tıp Dergisi

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Objective: The purpose of this study was to investigate the serum levels of selenium, zinc and copper on the etiology of idiopathic scoliosis in adolescents. Methods: Forty four idiopathic scoliosis patients between 10 and 17 years of age were considered in this study. The vertebra curvature degrees of the patients were between 28° and 82°. The idiopathic scoliosis patients were assigned to two groups based on their vertebra curvature degrees. Curvature degree of 45° and lower was labeled as group 1 and curvature of upper 45° was labeled as group 2. Total blood count, serum levels of selenium, zinc and copper were studied. Results: Thirty three of the idiopathic scoliosis patients (75%) were female. There was no statistically significant difference in serum zinc and copper levels between idiopathic scoliosis patients and the control group (p> 0.05). Serum selenium levels in idiopathic scoliosis patients were lower than that of the control group and the difference was statistically significant (p< 0.05). In terms of vertebra curvature degree and demographic characteristics of the patients, group 2 age average was significantly higher than that of the group 1 (p< 0.05). When serum selenium, zinc, and copper levels were compared based on the vertebra curvature degrees of the IS patients, no statistically significant difference was observed between group 1 and 2 in laboratory measurements (p > 0.05). Conclusion: Among the measured trace elements, selenium was lower in the serum of the IS patients. This is the first study in Turkey that we know of about this subject and we think that further studies are needed.

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“…This ratio is clinically more important than the concentration of each metal separately. A high level of Cu/Zn ratio is associated with increased OS, decreased capacity of the body to handle oxidant, and the increase in inflammatory response (37).…”

Section: Discussionmentioning

confidence: 99%

Antioxidants status in type 2 diabetic patients in Morocco

Eljaoudi

Elomri

Laamarti³

et al. 2017

Turk J Med Sci

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Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes.Materials and methods: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se).Results: CRP and triglycerides were higher in the diabetic group while high-density lipoprotein levels were significantly lower compared to the control group. Plasma MDA, Cu concentrations, and Cu/Zn ratio were found to be higher in diabetic patients compared to healthy subjects, while vitamin E, Zn, and Se concentrations were lower compared to the control group. No significant difference was found in vitamin C levels between the two groups. Plasma HbA1c was positively correlated to MDA levels. Conclusion:This study shows that antioxidant status is impaired in diabetics compared to healthy controls.

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Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis

Cited by 123 publications

References 39 publications

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Investigation of Serum Levels of Selenium, Zinc, and Copper in Adolescents with Idiopathic Scoliosis

Antioxidants status in type 2 diabetic patients in Morocco

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