CTXA hip: the effect of partial volume correction on volumetric bone mineral density data for cortical and trabecular bone

Liu, Y.; Wang, L.; Su, Yongbin; Brown, J.K.; Yang, Ruiyue; Zhang, Y.; Duanmu, Yangyang; Guo, Zhe; Zhang, W.; Yan, Chenxi; Dong, Yan; Cheng, Xiaoguang

doi:10.1007/s11657-020-00721-8

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…There is little literature in this field based on volumetric BMD (vBMD mg/cm 3 ) derived from quantitative computed tomography (QCT), another recognized technique for diagnosing osteoporosis. Compared with DXA, a 2-dimensional method, QCT measures vBMD from a 3-dimensional image ( 23 ) and can avoid the influence caused by scoliosis, osteoarthritis of spine and calcification of vessel and/or ligament. Some studies illustrated that vBMD may be a more accurate predictor of fracture risk than aBMD ( 24 , 25 ).…”

Section: Introductionmentioning

confidence: 99%

Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study

Liu

Yu²,

Li³

et al. 2022

Front. Endocrinol.

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PurposeThis study evaluated the prevalence of vertebral fractures (VF) in middle-aged and elderly Chinese men and women and explored the differences in lumbar spine volumetric bone mineral density (vBMD) derived from quantitative CT (QCT) between those with a grade 1 vertebral fracture and non-fractured individuals.Materials and methods3,457 participants were enrolled in the China Action on Spine and Hip Status (CASH) study and had upper abdominal CT examinations. Vertebral fractures were identified by Genant’s semi-quantitative method from lateral CT scout views or CT sagittal views. L1-3 vBMD was measured by Mindways QCT Pro v5.0 software. The characteristics of different fracture severity groups were compared using one-way ANOVA, independent-samples t-tests, and Kruskal-Wallis H-tests.Results1267 males (aged 62.77 ± 9.20 years) and 2170 females (aged 61.41 ± 9.01 years) were included in the analysis. In men, the prevalence of VF increased from 14.7% at age<50 years to 23.2% at age ≥70 years, and in women from 5.1% at age<50 years to 33.0% at age ≥70 years. Differences in mean age and vBMD were found between the different fracture grade groups. After age stratification, vBMD differences in men aged < 50 years old disappeared (p = 0.162) but remained in the older age bands. There was no significant difference in mean vBMD between those with multiple mild fractures and those with a single mild fracture.ConclusionIn women, the prevalence of VF increased rapidly after age 50, while it grew more slowly in men. In general, with the exception of men <50 years old, participants with a grade 1 VF had lower vBMD than non-fractured individuals. The majority of women younger than 50 with a grade 1 VF had normal bone mass. We recommend that a vertebral height reduction ratio of <25% be diagnosed as a deformity rather than a fracture in people under the age of 50. The presence of multiple mild fractured vertebrae does not imply lower BMD.

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Section: Introductionmentioning

confidence: 99%

Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study

Liu

Yu²,

Li³

et al. 2022

Front. Endocrinol.

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“…However, MRI not only visualizes the anatomical structure but also quantifies the proton density fat fraction (PDFF) with good spatial resolution, short acquisition time, and accurate fat quantification ( 13 , 14 ). Computed tomography X-ray absorptiometry (CTXA) is a QCTPro (Mindways Inc., Austin, TX) scanning analysis module, which generates two-dimensional (2D) images from three-dimensional (3D) images of the proximal femur region of interest (ROI) and evaluates the areal BMD (aBMD) of integral (Int), trabecular (Trab), and cortical (Cort) bone by region (femoral neck, FN; trochanter, TR; intertrochanter, IT) ( 15 ). In contrast to DXA, quantitative computed tomography (QCT) distinguishes cortical bone from trabecular bone.…”

Section: Introductionmentioning

confidence: 99%

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Wang

Zhang

et al. 2022

Front. Endocrinol.

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PurposeTo investigate the relationship of muscle atrophy and fat infiltration around the hip joint with areal bone mineral density (aBMD) in each subregion of the proximal femur.Materials and methodsIn total, 144 participants (66 women and 78 men) were examined by quantitative computed tomography (QCT), and areal bone mineral density (aBMD) of the femoral neck (FN), trochanter (TR), and intertrochanter (IT) of the proximal femur were obtained. The cross-sectional area (CSA) and proton density fat fraction (PDFF) of the gluteus maximus (G.MaxM), gluteus medius (G.MedM), gluteus minimus (G.MinM), and iliopsoas (IliopM) were obtained via magnetic resonance imaging (MRI) using the mDIXON-Quant sequence. A multivariate generalized linear model was used to evaluate the correlation of the CSA and PDFF of muscles with aBMD in all subregions of the proximal femur.ResultsThe FN integral (Int) aBMD was significantly associated with the G.MaxM CSA (men: P = 0.002; women: P = 0.008) and PDFF (men: P < 0.001; women: P = 0.047). Some muscle indexes were related to the FN aBMD in males or females, including the CSA of G.MedM, G.MinM, and IliopM as well as the PDFF of IliopM and G.MinM. Associations of hip muscle parameters with the TR Int aBMD in both males and females were observed, including G.MaxM CSA (men: P < 0.001; women: P = 0.028) and G.MaxM PDFF (men: P = 0.031; women: P = 0.038). Other muscle indexes, including G.MedM and IliopM, were related to the TR aBMD, mainly affecting the aBMD of TR cortical (Cort) and TR Int. The IT Int aBMD and IT Cort aBMD showed significant correlation with the muscle indexes of G. MaxM, IliopM, and G.MedM, including the PDFF and CSA in males and females. Further, more indicators of the G.MedM and IliopM correlated with the TR and IT aBMD compared to the FN aBMD.ConclusionsThe CSA of gluteus muscles and iliopsoas had a positive association with the aBMD in the proximal femur, and the PDFF of gluteus muscles and iliopsoas had a negative correlation with the aBMD in the proximal femur. In addition, there was an interaction of the proximal femur aBMD with the muscle size and fatty infiltration of hip muscles.

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Implant design on virtual digital human skull models for the creation of customized Patient-specific regenerative implants: biomechanical consideration

Lim¹,

Sng²,

Wong³

2023

Digital Human Modeling and Medicine

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CTXA hip: the effect of partial volume correction on volumetric bone mineral density data for cortical and trabecular bone

Cited by 4 publications

References 24 publications

Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study

Differences in spine volumetric bone mineral density between grade 1 vertebral fracture and non-fractured participants in the China action on spine and hip status study

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Implant design on virtual digital human skull models for the creation of customized Patient-specific regenerative implants: biomechanical consideration

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