CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

Abstract

SummaryBackgroundIn this study, we investigated the relationship of adiponectin with bone marker changes in Egyptian children and adolescents with T1DM and the effect of disease duration on these markers, as well as the possible correlations between adiponectin and bone markers in these patients.MethodsSixty Egyptian children and adolescent patients with T1DM were studied. Serum adiponectin and collagen breakdown products (cross-linked C-terminal telopeptide of collagen type l »CTX«) were measured and compared to the results of 20 age-matched healthy controls.ResultsAfter adjustment for age, BMI, Tanner stage and gender; (total) adiponectin was significantly higher in all T1DM patients. Serum level of CTX and 25(OH)D showed a marked decrease in diabetics with disease duration > 5 years. Serum level of (total) calcium and inorganic phosphorus (Pi) did not show significant difference from control. CTX was inversely correlated to FBG and T1DM duration. Pi was inversely, while 25(OH)D was directly correlated to FBG. Total calcium showed an inverse correlation with HbA1c. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM.ConclusionsAdiponectin showed no correlation with either CTX or bone homeostatic indices. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. We recommend further investigation of adiponectin isoforms in a population-based study, to establish a good age- and sex-related reference.

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“…Unhealthy diet and lack of exercise leads to obesity. The American Academy of Pediatrics recommends proper nutrition and exercise, as the first-line defence from obesity, related to prediabetes and hypertension among young people (21, 22, 23, 24). In our study, physical activity significantly affects diastolic blood pressure values ( Table VI ).…”

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“…As in cases of predominantly osteolytic BM in MBC, Houzé et al [93] were one of the first to study the carboxy-terminally peptide of type I collagen (CTX) as a potential bone resorption marker in urine of women with breast cancer-positive BM and observed that CTX was significantly elevated compared to healthy pre- and postmenopausal controls ( p < 0.01). Cloos et al further specified studies on CTX by differentiating isomerized, racemised, and cross-linked versions of CTX, and found that newly synthesized, ∼12 kDa, non-isomerized alpha CTX peptides (αCTX) and the cross-linked chains of αCTX (ααCTX) are preferentially released into urine of patients with BM [28, 29, 94]. Comparing urine samples of 100 women with MBC to the bone to patients with IBC without bone involvement ( n = 15) and normal controls ( n = 31), this study reported that levels were even more elevated ( p = 0.005 and p = < 0.0001, respectively) [29, 94].…”

“…Cloos et al further specified studies on CTX by differentiating isomerized, racemised, and cross-linked versions of CTX, and found that newly synthesized, ∼12 kDa, non-isomerized alpha CTX peptides (αCTX) and the cross-linked chains of αCTX (ααCTX) are preferentially released into urine of patients with BM [28, 29, 94]. Comparing urine samples of 100 women with MBC to the bone to patients with IBC without bone involvement ( n = 15) and normal controls ( n = 31), this study reported that levels were even more elevated ( p = 0.005 and p = < 0.0001, respectively) [29, 94]. The fact that αCTX and particularly ααCTX seem to be an interesting marker of monitor dysregulation in bone metabolism due to MBC was further supported by studies by Leeming et al, who observed that the number of distant BM ( n = 40), i.e.…”